ID   STAR_XENLA              Reviewed;         285 AA.
AC   Q9DG08; Q501Q7;
DT   06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT   18-SEP-2019, sequence version 2.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Steroidogenic acute regulatory protein;
DE            Short=StAR;
DE   AltName: Full=START domain-containing protein 1;
DE            Short=StARD1;
GN   Name=star;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RX   PubMed=11064158; DOI=10.1016/s0303-7207(00)00316-6;
RA   Bauer M.P., Bridgham J.T., Langenau D.M., Johnson A.L., Goetz F.W.;
RT   "Conservation of steroidogenic acute regulatory (StAR) protein structure
RT   and expression in vertebrates.";
RL   Mol. Cell. Endocrinol. 168:119-125(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a key role in steroid hormone synthesis by enhancing
CC       the metabolism of cholesterol into pregnenolone. Mediates the transfer
CC       of cholesterol from the outer mitochondrial membrane to the inner
CC       mitochondrial membrane where it is cleaved to pregnenolone (By
CC       similarity). {ECO:0000250|UniProtKB:P49675}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747,
CC         ChEBI:CHEBI:16113; Evidence={ECO:0000250|UniProtKB:P49675};
CC   -!- PATHWAY: Steroid metabolism; cholesterol metabolism.
CC       {ECO:0000250|UniProtKB:P49675}.
CC   -!- SUBUNIT: May interact with TSPO. {ECO:0000250|UniProtKB:P79245}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P51557}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG28595.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AF220437; AAG28595.1; ALT_INIT; mRNA.
DR   EMBL; BC095917; AAH95917.1; -; mRNA.
DR   RefSeq; NP_001167502.1; NM_001174031.1.
DR   AlphaFoldDB; Q9DG08; -.
DR   SMR; Q9DG08; -.
DR   PRIDE; Q9DG08; -.
DR   DNASU; 100381120; -.
DR   GeneID; 100381120; -.
DR   KEGG; xla:100381120; -.
DR   CTD; 100381120; -.
DR   Xenbase; XB-GENE-999725; star.L.
DR   UniPathway; UPA00296; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 100381120; Expressed in camera-type eye and 11 other tissues.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0015485; F:cholesterol binding; IEA:InterPro.
DR   GO; GO:0120020; F:cholesterol transfer activity; IEA:InterPro.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd08905; START_STARD1-like; 1.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR029866; StAR.
DR   InterPro; IPR000799; StAR-like.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   InterPro; IPR002913; START_lipid-bd_dom.
DR   PANTHER; PTHR46489; PTHR46489; 1.
DR   Pfam; PF01852; START; 1.
DR   PRINTS; PR00978; STARPROTEIN.
DR   SMART; SM00234; START; 1.
DR   PROSITE; PS50848; START; 1.
PE   2: Evidence at transcript level;
KW   Lipid transport; Lipid-binding; Mitochondrion; Reference proteome;
KW   Steroidogenesis; Transport.
FT   CHAIN           1..285
FT                   /note="Steroidogenic acute regulatory protein"
FT                   /id="PRO_0000220651"
FT   DOMAIN          67..280
FT                   /note="START"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00197"
FT   CONFLICT        1
FT                   /note="M -> L (in Ref. 1; AAG28595)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        234
FT                   /note="I -> V (in Ref. 1; AAG28595)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        276
FT                   /note="T -> A (in Ref. 1; AAG28595)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        280
FT                   /note="N -> T (in Ref. 1; AAG28595)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   285 AA;  31675 MW;  B75CD7167C45C77A CRC64;
     MLPATFKLCA GISYRHLRNM TGLRRTAAVA LTHELEKLAL VGPGPGKWIN QIRRKSILLS
     SRLEEKTLND VEMSYIKQGE EALKKSLNIL GDQDGWKTEI VMENGDKVLS KVLPDIGKVF
     KLEAVVEKPL DNVYGELVDN MEKMGEWNPN VKEVKILQKI GKDTVITHEK AAETPGNIVG
     ARDFVSVRCS KRRGSTCILA GMSTRFGGMP EQKGFVRGEN GPTCMVLRPL AEDISKTKLT
     WLLSIDLKGW LPKSIINQVL SQTQVDFAKH LRSRMTSSSN ALSLC