ID   STAT1_CAEBR             Reviewed;         713 AA.
AC   Q61AP6; A8XIG5;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 2.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Signal transducer and activator of transcription 1;
GN   Name=sta-1 {ECO:0000250|UniProtKB:Q9NAD6}; ORFNames=CBG13675;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Carries out a dual function: signal transduction and
CC       activation of transcription. Activated STAT proteins play a role in
CC       repression of dauer formation. Neuronal expression is held in check by
CC       negative signals through the TGF-beta pathway that target the daf-3
CC       transcription factor (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms a homodimer or a heterodimer with a related family
CC       member. {ECO:0000250|UniProtKB:P51692}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Note=Translocated into the nucleus in response to phosphorylation.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC       {ECO:0000255}.
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DR   EMBL; HE600943; CAP32439.2; -; Genomic_DNA.
DR   AlphaFoldDB; Q61AP6; -.
DR   SMR; Q61AP6; -.
DR   STRING; 6238.CBG13675; -.
DR   PRIDE; Q61AP6; -.
DR   EnsemblMetazoa; CBG13675a.1; CBG13675a.1; WBGene00034409.
DR   WormBase; CBG13675a; CBP37584; WBGene00034409; Cbr-sta-1.
DR   eggNOG; KOG3667; Eukaryota.
DR   HOGENOM; CLU_014189_4_0_1; -.
DR   InParanoid; Q61AP6; -.
DR   OMA; DKGHMSA; -.
DR   OrthoDB; 327469at2759; -.
DR   Proteomes; UP000008549; Chromosome IV.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006952; P:defense response; IBA:GO_Central.
DR   GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 2.60.40.630; -; 1.
DR   Gene3D; 3.30.505.10; -; 1.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR001217; STAT.
DR   InterPro; IPR013800; STAT_TF_alpha.
DR   InterPro; IPR015988; STAT_TF_coiled-coil.
DR   InterPro; IPR013801; STAT_TF_DNA-bd.
DR   InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR   PANTHER; PTHR11801; PTHR11801; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF01017; STAT_alpha; 1.
DR   Pfam; PF02864; STAT_bind; 1.
DR   SUPFAM; SSF47655; SSF47655; 1.
DR   SUPFAM; SSF49417; SSF49417; 1.
DR   SUPFAM; SSF55550; SSF55550; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; Developmental protein; DNA-binding; Nucleus;
KW   Phosphoprotein; Reference proteome; SH2 domain; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..713
FT                   /note="Signal transducer and activator of transcription 1"
FT                   /id="PRO_0000234103"
FT   DOMAIN          477..574
FT                   /note="SH2"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   713 AA;  81147 MW;  B056AC8FD6CA3155 CRC64;
     MMGSSSQELQ TALTDISKTC HHMWEDSKDL QGRFVNDLAE LQRLQCTITN FERAQHPEQA
     FQAKQAMTEM QKKATGVYEM LAQRRNEIIS KLNDGANIAS MMQGQLINDK LFTWKNAQKL
     AQIGMPFDDR EQLLDEIQLE FEFLADNIWQ LNMFACWMCD LCRRAPQLND GLAQSSAAKL
     TTISEQLNRL LFVLVSQSFI VSVQPEPVLK TQHKFVTEVR LLIGDKLGIR QQLMNTNVSV
     KIIAEDEARV MSVDCDAQKE IRANKQVGSI SNDFEKLTMD ERGHLSAKFN NSKLTRIAHR
     KPPPKGASDM KCAANMQAAT DQKYALLFFI TPFQMGNLSK EEQLDVWTLS LPIMVTVHGS
     QDCDAQVAIL WHRAFASISR DPNVHDVTAV SWENLAIMLR NKFSLFTGAR RPLSESDLAY
     LSEKIIIPNM PDQKPITFTR FAKQAMREEL AFSFWEWFFS IMQLIKQKLL KYWDEGWCIG
     FISKHDASQS MCMLPNTSFL LRFSDTQTGA VSIGFVCQDD DGQKVPFHLS PLTIKDLDQL
     SLASRIASCP QLKDIRYMYP NIDKEEMLRY FESEERHRVG GPESPGGYIQ SEIVMVAKTN
     GNFRRASAAP SMFGADSPSP LSIQSKLDWS PGEIHQSMME MTDELGHVLN VGGMDSMHPD
     ANTLLGPAFK NPTFHPHDQQ QHLQFVDMSH PQMMQQQHHG HNHNHTHNQF YPS