STAT3_CHICK
ID STAT3_CHICK Reviewed; 771 AA.
AC Q6DV79; Q5F331;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Signal transducer and activator of transcription 3;
GN Name=STAT3; ORFNames=RCJMB04_38l20;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Zhou G.Y., Leung F.C.;
RT "Characterization of 5' flanking sequence of chicken SOCS2 gene.";
RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
RN [3]
RP FUNCTION, AND PHOSPHORYLATION AT TYR-706.
RX PubMed=15910996; DOI=10.1016/j.vetimm.2005.01.006;
RA Nishimichi N., Aosasa M., Kawashima T., Horiuchi H., Furusawa S.,
RA Matsuda H.;
RT "Biological activity of recombinant chicken interleukin-6 in chicken
RT hybridoma cells.";
RL Vet. Immunol. Immunopathol. 106:97-105(2005).
CC -!- FUNCTION: Transcription factor that binds to the interleukin-6 (IL-6)-
CC responsive elements identified in the promoters of various acute-phase
CC protein genes. {ECO:0000250, ECO:0000269|PubMed:15910996}.
CC -!- SUBUNIT: Forms a homodimer or a heterodimer with a related family
CC member, such as STAT1. Interacts with OCAD1 (By similarity).
CC {ECO:0000250, ECO:0000250|UniProtKB:P42227}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between the
CC nucleus and the cytoplasm. Constitutive nuclear presence is independent
CC of tyrosine phosphorylation (By similarity). {ECO:0000250}.
CC -!- MISCELLANEOUS: Involved in the gp130-mediated signaling pathway.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000305}.
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DR EMBL; AY641397; AAT64887.1; -; mRNA.
DR EMBL; AJ851819; CAH65453.1; -; mRNA.
DR RefSeq; NP_001026102.1; NM_001030931.1.
DR RefSeq; XP_015155084.1; XM_015299598.1.
DR RefSeq; XP_015155085.1; XM_015299599.1.
DR AlphaFoldDB; Q6DV79; -.
DR SMR; Q6DV79; -.
DR STRING; 9031.ENSGALP00000005161; -.
DR iPTMnet; Q6DV79; -.
DR PaxDb; Q6DV79; -.
DR Ensembl; ENSGALT00000005170; ENSGALP00000005161; ENSGALG00000003267.
DR GeneID; 420027; -.
DR KEGG; gga:420027; -.
DR CTD; 6774; -.
DR VEuPathDB; HostDB:geneid_420027; -.
DR eggNOG; KOG3667; Eukaryota.
DR GeneTree; ENSGT01050000244905; -.
DR HOGENOM; CLU_014189_3_0_1; -.
DR InParanoid; Q6DV79; -.
DR OMA; RCLWEEN; -.
DR OrthoDB; 327469at2759; -.
DR PhylomeDB; Q6DV79; -.
DR Reactome; R-GGA-1059683; Interleukin-6 signaling.
DR Reactome; R-GGA-1266695; Interleukin-7 signaling.
DR Reactome; R-GGA-186763; Downstream signal transduction.
DR Reactome; R-GGA-201556; Signaling by ALK.
DR Reactome; R-GGA-6783783; Interleukin-10 signaling.
DR Reactome; R-GGA-6785807; Interleukin-4 and Interleukin-13 signaling.
DR Reactome; R-GGA-8854691; Interleukin-20 family signaling.
DR Reactome; R-GGA-8875791; MET activates STAT3.
DR Reactome; R-GGA-8983432; Interleukin-15 signaling.
DR Reactome; R-GGA-8985947; Interleukin-9 signaling.
DR Reactome; R-GGA-9008059; Interleukin-37 signaling.
DR Reactome; R-GGA-9020933; Interleukin-23 signaling.
DR Reactome; R-GGA-9020956; Interleukin-27 signaling.
DR Reactome; R-GGA-9020958; Interleukin-21 signaling.
DR Reactome; R-GGA-9701898; STAT3 nuclear events downstream of ALK signaling.
DR PRO; PR:Q6DV79; -.
DR Proteomes; UP000000539; Chromosome 27.
DR Bgee; ENSGALG00000003267; Expressed in lung and 12 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; ISS:AgBase.
DR GO; GO:0046983; F:protein dimerization activity; ISS:UniProtKB.
DR GO; GO:0019901; F:protein kinase binding; ISS:UniProtKB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006952; P:defense response; IBA:GO_Central.
DR GO; GO:0042755; P:eating behavior; ISS:UniProtKB.
DR GO; GO:0001754; P:eye photoreceptor cell differentiation; ISS:UniProtKB.
DR GO; GO:0042593; P:glucose homeostasis; ISS:UniProtKB.
DR GO; GO:0060397; P:growth hormone receptor signaling pathway via JAK-STAT; ISS:UniProtKB.
DR GO; GO:0033210; P:leptin-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0040014; P:regulation of multicellular organism growth; ISS:AgBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:AgBase.
DR GO; GO:0043434; P:response to peptide hormone; IBA:GO_Central.
DR GO; GO:0019953; P:sexual reproduction; ISS:UniProtKB.
DR GO; GO:0001659; P:temperature homeostasis; ISS:UniProtKB.
DR GO; GO:0006366; P:transcription by RNA polymerase II; ISS:AgBase.
DR CDD; cd10374; SH2_STAT3; 1.
DR Gene3D; 1.10.532.10; -; 1.
DR Gene3D; 2.60.40.630; -; 1.
DR Gene3D; 3.30.505.10; -; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR035855; STAT3_SH2.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; PTHR11801; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF47655; SSF47655; 1.
DR SUPFAM; SSF48092; SSF48092; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR SUPFAM; SSF55550; SSF55550; 1.
DR PROSITE; PS50001; SH2; 1.
PE 1: Evidence at protein level;
KW Activator; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein;
KW Reference proteome; SH2 domain; Transcription; Transcription regulation.
FT CHAIN 1..771
FT /note="Signal transducer and activator of transcription 3"
FT /id="PRO_0000347217"
FT DOMAIN 580..670
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT MOTIF 150..162
FT /note="Essential for nuclear import"
FT /evidence="ECO:0000250"
FT MOD_RES 706
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000269|PubMed:15910996"
FT CONFLICT 23
FT /note="S -> G (in Ref. 1; AAT64887)"
FT /evidence="ECO:0000305"
FT CONFLICT 339
FT /note="I -> F (in Ref. 1; AAT64887)"
FT /evidence="ECO:0000305"
FT CONFLICT 542
FT /note="Missing (in Ref. 2; CAH65453)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 771 AA; 88171 MW; BC4B668CE787010B CRC64;
MAQWNQLQQL DTRYLEQLHQ LYSDSFPMEL RQFLAPWIES QDWAYAANKE SHATLVFHNL
LGEIDQQYSR FLQESNVLYQ HNLRRIKQFL QSRYLEKPME IARIVARCLW EESRLLQTAA
TAAQQGGQAT HPTAAVVTEK QQMLEQHLQD VRKRVQDLEQ KMKVVENLQD DFDFNYKTLK
SQGDMQDLNG NNQSVTRQKM QQLEQMLTAL DQMRRGIVSE LAGLLSAMEY VQKMLADEEL
ADWKRRQQIA CIGGPPNICL DRLENWITSL AESQLQTRQQ IKKLEELQQK VSYKGDPIVQ
HRPMLEERIV ELFRNLMKSA FVVERQPCMP MHPDRPLVIK TGVQFTTKVR LLVKFPELNY
QLKIKVCIDK DSGDVAALRG SRKFNILGTN TKVMNMEESN NGSLSAEFKH LTLREQRCGN
GGRANCDASL IVTEELHLIT FETEVYHQGL KIDLETHSLP VVVISNICQM PNAWASILWY
NMLTNNPKNV NFFTKPPIGT WDQVAEVLSW QFSSTTKRGL SIEQLTTLAE KLLGPGVNYS
GCQITWAKFC KENMAGKGFS FWVWLDNIID LVKKYILALW NEGYIMGFIS KERERAILST
KPPGTFLLRF SESSKEGGIT FTWVEKDISG KTQIQSVEPY TKQQLNSMSF AEIIMGYKIM
DATNILVSPL VYLYPDIPKE EAFGKYCRSE SQEHSEATDS GSAAPYLKTK FICVTPTSFS
NTIDLPMSPR TLDSLMQFGN SSEGAEANAG GQFESLTFDM ELTQECASSP M
