STATB_DICDI
ID STATB_DICDI Reviewed; 1148 AA.
AC Q70GP4; Q55F36;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Signal transducer and activator of transcription B;
DE AltName: Full=Dd-STATb;
DE AltName: Full=STAT5 homolog B;
GN Name=dstB; Synonyms=statB; ORFNames=DDB_G0268638;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT, SUBCELLULAR LOCATION,
RP DEVELOPMENTAL STAGE, LACK OF PHOSPHORYLATION, MUTAGENESIS OF LEU-1026 AND
RP TYR-1144, AND DISRUPTION PHENOTYPE.
RC STRAIN=AX2;
RX PubMed=14701681; DOI=10.1242/dev.00927;
RA Zhukovskaya N.V., Fukuzawa M., Tsujioka M., Jermyn K.A., Kawata T., Abe T.,
RA Zvelebil M., Williams J.G.;
RT "Dd-STATb, a Dictyostelium STAT protein with a highly aberrant SH2 domain,
RT functions as a regulator of gene expression during growth and early
RT development.";
RL Development 131:447-458(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Transcription factor that regulates gene expression during
CC development. Required for optimal cell growth.
CC {ECO:0000269|PubMed:14701681}.
CC -!- SUBUNIT: Homodimer. Does not form heterodimers with other family
CC members. {ECO:0000269|PubMed:14701681}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14701681}.
CC Note=Predominantly nuclear in growing cells and throughout development.
CC -!- DEVELOPMENTAL STAGE: Detected at low levels in growing cells. Levels
CC are higher during development and decrease again at culmination.
CC {ECO:0000269|PubMed:14701681}.
CC -!- DISRUPTION PHENOTYPE: Cells develop normally and show no evident
CC defects. Still, these cells seem to be at a selective growth
CC disadvantage. {ECO:0000269|PubMed:14701681}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000305}.
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DR EMBL; AJ581661; CAE46396.1; -; mRNA.
DR EMBL; AAFI02000004; EAL72908.1; -; Genomic_DNA.
DR RefSeq; XP_646834.1; XM_641742.1.
DR AlphaFoldDB; Q70GP4; -.
DR SMR; Q70GP4; -.
DR STRING; 44689.DDB0191116; -.
DR PaxDb; Q70GP4; -.
DR EnsemblProtists; EAL72908; EAL72908; DDB_G0268638.
DR GeneID; 8616516; -.
DR KEGG; ddi:DDB_G0268638; -.
DR dictyBase; DDB_G0268638; dstB.
DR HOGENOM; CLU_276871_0_0_1; -.
DR InParanoid; Q70GP4; -.
DR OMA; FPMVISK; -.
DR Reactome; R-DDI-1059683; Interleukin-6 signaling.
DR Reactome; R-DDI-1169408; ISG15 antiviral mechanism.
DR Reactome; R-DDI-201556; Signaling by ALK.
DR Reactome; R-DDI-3249367; STAT6-mediated induction of chemokines.
DR Reactome; R-DDI-6783783; Interleukin-10 signaling.
DR Reactome; R-DDI-6785807; Interleukin-4 and Interleukin-13 signaling.
DR Reactome; R-DDI-877300; Interferon gamma signaling.
DR Reactome; R-DDI-877312; Regulation of IFNG signaling.
DR Reactome; R-DDI-8854691; Interleukin-20 family signaling.
DR Reactome; R-DDI-8983432; Interleukin-15 signaling.
DR Reactome; R-DDI-8984722; Interleukin-35 Signalling.
DR Reactome; R-DDI-8985947; Interleukin-9 signaling.
DR Reactome; R-DDI-9008059; Interleukin-37 signaling.
DR Reactome; R-DDI-9020591; Interleukin-12 signaling.
DR Reactome; R-DDI-9020933; Interleukin-23 signaling.
DR Reactome; R-DDI-9020956; Interleukin-27 signaling.
DR Reactome; R-DDI-909733; Interferon alpha/beta signaling.
DR Reactome; R-DDI-9701898; STAT3 nuclear events downstream of ALK signaling.
DR PRO; PR:Q70GP4; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IDA:dictyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IPI:dictyBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006952; P:defense response; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:dictyBase.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IMP:dictyBase.
DR GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR GO; GO:0042127; P:regulation of cell population proliferation; IMP:dictyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 2.60.40.340; -; 1.
DR Gene3D; 3.30.505.10; -; 1.
DR InterPro; IPR041604; EF-hand_12.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR015347; STAT_TF_homologue_coiled-coil.
DR InterPro; IPR041410; STATa_Ig.
DR PANTHER; PTHR11801; PTHR11801; 3.
DR Pfam; PF09267; Dict-STAT-coil; 1.
DR Pfam; PF17901; EF-hand_12; 1.
DR Pfam; PF18214; STATa_Ig; 1.
DR SUPFAM; SSF47655; SSF47655; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR SUPFAM; SSF55550; SSF55550; 1.
DR PROSITE; PS50001; SH2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; SH2 domain; Transcription;
KW Transcription regulation.
FT CHAIN 1..1148
FT /note="Signal transducer and activator of transcription B"
FT /id="PRO_0000328286"
FT DOMAIN 997..1122
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT REGION 1..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 93..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 268..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 403..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..613
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 1026
FT /note="L->R: No effect on dimerization and on nuclear
FT location."
FT /evidence="ECO:0000269|PubMed:14701681"
FT MUTAGEN 1144
FT /note="Y->F: No effect on dimerization and on nuclear
FT location."
FT /evidence="ECO:0000269|PubMed:14701681"
SQ SEQUENCE 1148 AA; 129275 MW; D298FE5318A2D63F CRC64;
MEVTNNGSNN SSTIASTNPP TSPSTTSTSK SLPPLSFLNS QWENKQSNNN NNSNNNNINN
NNNNNNNNNN NNNNNNNNNN NSVKMEKLIE LPSSSNNSPE FLNGVNNNNN GNNNNNNNNN
NNNNNNNNNN NNNNNNNNNN NNNNNNNSGS GGNNSNNNSN ISSPPSSSST STSVLSSSQS
AYMNDKMVAA TLDSIGKMES IQRKYEMQIE SLMDQIQGYI EKEQKLRSQC QAVEDINAKL
ENENLQLKKE LFEMSRKFKE IDIINLNNTN NNINNNNNNN NNNNNNNNNN SINNNNNNGF
SPPPLVKYPS NGSLQQDAKR FKIMEQQSQQ QQQMQQQQQI QQQKQYQQQQ QQTTSKRKNN
ISIDGDKEAL VAEALGSFVD YAKPSLKRSN SEEVFNSSVY KNKNNINNIN NNSNSNNNNG
NNSLLNDIQN WQQQQQQQQQ LLHQRKKRKD YDYDYNSTQN GKGIPSNSSN NNSSNNNSNN
NNNNNSNNNN NIIGSISPPH SSQLQQVSSP QQQQQQQKPN GLKLSISSGS IKDLINSPNK
EQSSKSQYPS SLSQSSSIPD MDTDVDSTDE FDFGSNSNNN NNNNNNNNNN NNSNNSNNKK
RNNSNNNNLG GDDDDSPDSN DRNGSSSPID MEPSYDGANL FKTVTPGTIT TPQEELLNEI
HSLQMQQRET IEKMYIAQKQ FLSDRSNGFN NNNEEILRSL QSDQTKLGST LESELQALNQ
LYSQTILEPN QLCKLDILLQ DVSIQLKQLH LYQMELNYGY GSNEPFPATL VIIKQPFPMV
ISKFKQLQED HLCVQLLTGA NVEIVSYSPI RAELVFHSKN LTKGSSNLGT QNSLKKNIEK
DTQVLDPIKG VAKFPIKFLT GTRKSCVKLH FVLQIKTSDG HIINVPSSTS QPFIVITNDC
QWEGSEGTLL KKETFNEKFE ISWPHFVNIL QKHFLKATKQ SPIQPTRPLS MYDFTYLSNT
FFGGKPFVSH KDFDSFWSWF GKSIQTLRYK RHISTLWQNG FIFMFLKRDV VTQILKNQDV
GTFVILFSEA FPGQLEISYV GTDQKDSLSK SSNDLQSPTT TTTTTTSTRV KHYLVQANDT
SGSKRTLPDF LSECNQFTHI LQLNIAMIPQ TETIPVFKRE PKNVVLEPYY SKRQNSQNIL
GSGYDPLF
