ID   STAT_BOVIN              Reviewed;          59 AA.
AC   Q8HY86;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Statherin;
DE   Flags: Precursor;
GN   Name=STATH;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Salivary gland;
RX   PubMed=13679022; DOI=10.1016/s0888-7543(03)00114-9;
RA   Rijnkels M., Elnitski L., Miller W., Rosen J.M.;
RT   "Multispecies comparative analysis of a mammalian-specific genomic domain
RT   encoding secretory proteins.";
RL   Genomics 82:417-432(2003).
CC   -!- FUNCTION: Salivary protein that stabilizes saliva supersaturated with
CC       calcium salts by inhibiting the precipitation of calcium phosphate
CC       salts. It also modulates hydroxyapatite crystal formation on the tooth
CC       surface (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the histatin/statherin family. {ECO:0000305}.
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DR   EMBL; AY154893; AAN85581.1; -; mRNA.
DR   RefSeq; NP_777177.1; NM_174752.3.
DR   AlphaFoldDB; Q8HY86; -.
DR   STRING; 9913.ENSBTAP00000034263; -.
DR   PaxDb; Q8HY86; -.
DR   GeneID; 286765; -.
DR   KEGG; bta:286765; -.
DR   CTD; 6779; -.
DR   eggNOG; ENOG502TD51; Eukaryota.
DR   HOGENOM; CLU_208169_0_0_1; -.
DR   InParanoid; Q8HY86; -.
DR   OrthoDB; 1640595at2759; -.
DR   TreeFam; TF341588; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0046848; F:hydroxyapatite binding; IEA:InterPro.
DR   GO; GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:InterPro.
DR   GO; GO:0030500; P:regulation of bone mineralization; IEA:InterPro.
DR   InterPro; IPR030773; Histatin/statherin.
DR   InterPro; IPR005575; Statherin.
DR   PANTHER; PTHR15057; PTHR15057; 1.
DR   PIRSF; PIRSF002565; Statherin; 1.
PE   3: Inferred from homology;
KW   Biomineralization; Phosphoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..59
FT                   /note="Statherin"
FT                   /id="PRO_0000320549"
FT   MOD_RES         21
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02808"
FT   MOD_RES         22
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02808"
SQ   SEQUENCE   59 AA;  7093 MW;  EE9866EE60B21F25 CRC64;
     MKIFFFAFIM ALMVAMIKAD SSEEEHRLRF NPRFYYPNQQ GGYIPSYPAY PYPYPYPVQ