STAT_MACAR
ID STAT_MACAR Reviewed; 42 AA.
AC P14709;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 25-MAY-2022, entry version 60.
DE RecName: Full=Statherin;
GN Name=STATH;
OS Macaca arctoides (Stump-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9540;
RN [1]
RP PROTEIN SEQUENCE, AND PHOSPHORYLATION AT SER-2 AND SER-3.
RX PubMed=2613439; DOI=10.1111/j.1399-3011.1989.tb00705.x;
RA Schlesinger D.H., Hay D.I., Levine M.J.;
RT "Complete primary structure of statherin, a potent inhibitor of calcium
RT phosphate precipitation, from the saliva of the monkey, Macaca arctoides.";
RL Int. J. Pept. Protein Res. 34:374-380(1989).
CC -!- FUNCTION: Salivary protein that stabilizes saliva supersaturated with
CC calcium salts by inhibiting the precipitation of calcium phosphate
CC salts. It also modulates hydroxyapatite crystal formation on the tooth
CC surface.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Secreted by parotid and submandibular glands.
CC -!- SIMILARITY: Belongs to the histatin/statherin family. {ECO:0000305}.
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DR PIR; JK0224; JK0224.
DR AlphaFoldDB; P14709; -.
DR iPTMnet; P14709; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0046848; F:hydroxyapatite binding; IEA:InterPro.
DR GO; GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IEA:InterPro.
DR GO; GO:0030500; P:regulation of bone mineralization; IEA:InterPro.
DR InterPro; IPR005575; Statherin.
DR Pfam; PF03875; Statherin; 1.
DR PIRSF; PIRSF002565; Statherin; 1.
PE 1: Evidence at protein level;
KW Biomineralization; Direct protein sequencing; Phosphoprotein; Secreted.
FT CHAIN 1..42
FT /note="Statherin"
FT /id="PRO_0000072242"
FT REGION 1..6
FT /note="Hydroxyapatite-binding; inhibits crystal growth"
FT REGION 18..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 18..42
FT /note="Hydrophobic; inhibits precipitation of calcium
FT phosphate salts"
FT COMPBIAS 22..42
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:2613439"
FT MOD_RES 3
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:2613439"
SQ SEQUENCE 42 AA; 5207 MW; E0630E5B1184C506 CRC64;
DSSEEKFLRR LRRFDEGRYG PYQPFVPPPL YPQPYQPYQP QY