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STAT_MACAR
ID   STAT_MACAR              Reviewed;          42 AA.
AC   P14709;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Statherin;
GN   Name=STATH;
OS   Macaca arctoides (Stump-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9540;
RN   [1]
RP   PROTEIN SEQUENCE, AND PHOSPHORYLATION AT SER-2 AND SER-3.
RX   PubMed=2613439; DOI=10.1111/j.1399-3011.1989.tb00705.x;
RA   Schlesinger D.H., Hay D.I., Levine M.J.;
RT   "Complete primary structure of statherin, a potent inhibitor of calcium
RT   phosphate precipitation, from the saliva of the monkey, Macaca arctoides.";
RL   Int. J. Pept. Protein Res. 34:374-380(1989).
CC   -!- FUNCTION: Salivary protein that stabilizes saliva supersaturated with
CC       calcium salts by inhibiting the precipitation of calcium phosphate
CC       salts. It also modulates hydroxyapatite crystal formation on the tooth
CC       surface.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Secreted by parotid and submandibular glands.
CC   -!- SIMILARITY: Belongs to the histatin/statherin family. {ECO:0000305}.
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DR   PIR; JK0224; JK0224.
DR   AlphaFoldDB; P14709; -.
DR   iPTMnet; P14709; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0046848; F:hydroxyapatite binding; IEA:InterPro.
DR   GO; GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:InterPro.
DR   GO; GO:0030500; P:regulation of bone mineralization; IEA:InterPro.
DR   InterPro; IPR005575; Statherin.
DR   Pfam; PF03875; Statherin; 1.
DR   PIRSF; PIRSF002565; Statherin; 1.
PE   1: Evidence at protein level;
KW   Biomineralization; Direct protein sequencing; Phosphoprotein; Secreted.
FT   CHAIN           1..42
FT                   /note="Statherin"
FT                   /id="PRO_0000072242"
FT   REGION          1..6
FT                   /note="Hydroxyapatite-binding; inhibits crystal growth"
FT   REGION          18..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          18..42
FT                   /note="Hydrophobic; inhibits precipitation of calcium
FT                   phosphate salts"
FT   COMPBIAS        22..42
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:2613439"
FT   MOD_RES         3
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:2613439"
SQ   SEQUENCE   42 AA;  5207 MW;  E0630E5B1184C506 CRC64;
     DSSEEKFLRR LRRFDEGRYG PYQPFVPPPL YPQPYQPYQP QY
 
 
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