ID   STAU2_DANRE             Reviewed;         606 AA.
AC   Q7ZW47;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 2.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Double-stranded RNA-binding protein Staufen homolog 2;
GN   Name=stau2; ORFNames=zgc:55287;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein required for the microtubule-dependent
CC       transport of RNAs within polarized cell types. {ECO:0000250}.
CC   -!- DOMAIN: The DRBM 3 domain appears to be the major RNA-binding
CC       determinant. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH45292.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC045292; AAH45292.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q7ZW47; -.
DR   SMR; Q7ZW47; -.
DR   STRING; 7955.ENSDARP00000116175; -.
DR   PaxDb; Q7ZW47; -.
DR   ZFIN; ZDB-GENE-040426-687; stau2.
DR   eggNOG; KOG3732; Eukaryota.
DR   InParanoid; Q7ZW47; -.
DR   PhylomeDB; Q7ZW47; -.
DR   PRO; PR:Q7ZW47; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0010494; C:cytoplasmic stress granule; IBA:GO_Central.
DR   GO; GO:1990124; C:messenger ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0098964; P:anterograde dendritic transport of messenger ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0007281; P:germ cell development; IMP:ZFIN.
DR   GO; GO:0008354; P:germ cell migration; IMP:ZFIN.
DR   GO; GO:0008298; P:intracellular mRNA localization; IBA:GO_Central.
DR   GO; GO:0035418; P:protein localization to synapse; IBA:GO_Central.
DR   CDD; cd19880; DSRM_STAU2_rpt1; 1.
DR   CDD; cd19882; DSRM_STAU2_rpt2; 1.
DR   CDD; cd19884; DSRM_STAU2_rpt3; 1.
DR   CDD; cd19886; DSRM_STAU2_rpt4; 1.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR044476; STAU2_DSRM_1.
DR   InterPro; IPR044464; STAU2_DSRM_2.
DR   InterPro; IPR044473; STAU2_DSRM_3.
DR   InterPro; IPR044474; STAU2_DSRM_4.
DR   InterPro; IPR032478; Staufen_C.
DR   Pfam; PF00035; dsrm; 4.
DR   Pfam; PF16482; Staufen_C; 1.
DR   SMART; SM00358; DSRM; 5.
DR   PROSITE; PS50137; DS_RBD; 5.
PE   2: Evidence at transcript level;
KW   Microtubule; Reference proteome; Repeat; RNA-binding; Transport.
FT   CHAIN           1..606
FT                   /note="Double-stranded RNA-binding protein Staufen homolog
FT                   2"
FT                   /id="PRO_0000072245"
FT   DOMAIN          8..75
FT                   /note="DRBM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT   DOMAIN          95..181
FT                   /note="DRBM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT   DOMAIN          207..274
FT                   /note="DRBM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT   DOMAIN          307..375
FT                   /note="DRBM 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT   DOMAIN          493..557
FT                   /note="DRBM 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT   REGION          57..97
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          177..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          580..606
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        57..71
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        187..204
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   606 AA;  66504 MW;  49D98855D0A5D0F7 CRC64;
     MANPKEKTPM CLVNELARFN RIQPQYKLLN EKGPAHAKIF TVQLCLGNQV WESEGSSIKK
     AQHSTATKAL AESSLPRPPP RSPKADSNSN PGSITPTVEL NGLAMKRGEP AIYRPLDPKP
     IPNYRANYNF RGMFNQRYHY PVPKVFYVQL TVGNNEFIGE GRTRQAARHN AAMKALQALK
     NEPIPERPPQ CSEEKKETEE NSDASKSEIS LVYEIALKRN LPVNFEVLKE SGPPHMKSFL
     TRVTVGEFSA EGEGNSKKLS KKRAALSILQ ELKKLPVLPV VEKPKVHYKK RPKTILKTGP
     EYGQGMNPIS RLAQIQQAKK EKEPEYMLLS ERGMPRRREF IMQVKVGTEV TTGTGPNKKV
     AKRNAAEAML LQLGYKASTP LQNTPEKMDN KGWNGQRAAF PETTSNTQKG ILHLSPDVYQ
     EMEASRNKGV PGAPGNFPTA KEIGQGSAGP FCTPSVGNTA TIAKELLLSG TSPTAEALVL
     KGKAPALACG SIQPSQQLEY LAHIQGFQVQ YSDRQTDKEF MTYLTLSPVQ MTFHGIGSSI
     PASHDQAALS ALKQLSEQGL DPVDGPIKVE NGSCDIQAKR LAERTESKPT NSGTTAQDCK
     DSKAVV