ID   STAU2_XENTR             Reviewed;         624 AA.
AC   Q5M7M7;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Double-stranded RNA-binding protein Staufen homolog 2;
GN   Name=stau2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: RNA-binding protein required for the microtubule-dependent
CC       transport of RNAs within polarized cell types. {ECO:0000250}.
CC   -!- DOMAIN: The DRBM 3 domain appears to be the major RNA-binding
CC       determinant. {ECO:0000250}.
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DR   EMBL; BC088555; AAH88555.1; -; mRNA.
DR   RefSeq; NP_001011376.2; NM_001011376.2.
DR   AlphaFoldDB; Q5M7M7; -.
DR   SMR; Q5M7M7; -.
DR   STRING; 8364.ENSXETP00000025855; -.
DR   PaxDb; Q5M7M7; -.
DR   DNASU; 496843; -.
DR   GeneID; 496843; -.
DR   KEGG; xtr:496843; -.
DR   CTD; 27067; -.
DR   Xenbase; XB-GENE-491508; stau2.
DR   eggNOG; KOG3732; Eukaryota.
DR   InParanoid; Q5M7M7; -.
DR   OrthoDB; 823092at2759; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0010494; C:cytoplasmic stress granule; IBA:GO_Central.
DR   GO; GO:1990124; C:messenger ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0003725; F:double-stranded RNA binding; IBA:GO_Central.
DR   GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR   GO; GO:0098964; P:anterograde dendritic transport of messenger ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0007281; P:germ cell development; IBA:GO_Central.
DR   GO; GO:0008298; P:intracellular mRNA localization; IBA:GO_Central.
DR   GO; GO:0035418; P:protein localization to synapse; IBA:GO_Central.
DR   CDD; cd19880; DSRM_STAU2_rpt1; 1.
DR   CDD; cd19882; DSRM_STAU2_rpt2; 1.
DR   CDD; cd19884; DSRM_STAU2_rpt3; 1.
DR   CDD; cd19886; DSRM_STAU2_rpt4; 1.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR044476; STAU2_DSRM_1.
DR   InterPro; IPR044464; STAU2_DSRM_2.
DR   InterPro; IPR044473; STAU2_DSRM_3.
DR   InterPro; IPR044474; STAU2_DSRM_4.
DR   InterPro; IPR032478; Staufen_C.
DR   Pfam; PF00035; dsrm; 3.
DR   Pfam; PF16482; Staufen_C; 1.
DR   SMART; SM00358; DSRM; 5.
DR   PROSITE; PS50137; DS_RBD; 4.
PE   2: Evidence at transcript level;
KW   Microtubule; Reference proteome; Repeat; RNA-binding; Transport.
FT   CHAIN           1..624
FT                   /note="Double-stranded RNA-binding protein Staufen homolog
FT                   2"
FT                   /id="PRO_0000072249"
FT   DOMAIN          55..122
FT                   /note="DRBM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT   DOMAIN          142..228
FT                   /note="DRBM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT   DOMAIN          254..321
FT                   /note="DRBM 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT   DOMAIN          354..422
FT                   /note="DRBM 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT   DOMAIN          540..604
FT                   /note="DRBM 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT   REGION          197..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          401..428
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          592..624
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   624 AA;  68613 MW;  0E9F5FF876147AA8 CRC64;
     MTNPKEKTPM CLVNELARFN RIQPQYKLLD ERGPAHSKLF TVQLTLGEQT WQAESTSIKK
     AQHAAASLAL SETTLPKPAA RQTKNHMNNN PEAAELHGNT FTSSRHSAKG SITPTVELNG
     LAMRRGEPAI YRSLDPKPLP NQRANYNYRG MYHQRYLCPM LKTFYVQLTV GNSEFYGEGK
     TRQAARHNAA LKALHALRNE PIPERSSLNG EANRGPEEDK DANKSEISLV FEISLKRNLS
     LSFEVIKESG PPHMKSFVTR VTVGEFTAEG EGNSKKLAKR RAAAAVLQEL RKLPPLPVIE
     KPRIYIKRRP KNIIKASPEY GQGMNPISRL AQIQQAKKEK EPEYVLLSER GIQRRREFVM
     QVKVGEETAT GTGPNKKTAK RNAAEAMLLQ LGYKASSPVV EKTGKRGENP DWDEQNSGIA
     DQTSTPKGIL HLSPDVYQEM EASRNKTVPA PAISYLSSKE MNQASSSFFS TSVSQSCTAA
     IARELLTNGT SPTAEAIGFT GKNLMCHSST VQPSKQLEYL AGIQGLQVNY SDRQSGNDFL
     TCLTLSPVQM TFHGIGSSLE ASHDQAALSA LKQFSEQGLD SVDGSLMAEN GPFEQAKLRG
     EKADNKQANS GTIAQDCKDS KAVV