STAUH_APLCA
ID STAUH_APLCA Reviewed; 950 AA.
AC Q3L1C9; E2QDA4;
DT 05-OCT-2016, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 25-MAY-2022, entry version 49.
DE RecName: Full=Double-stranded RNA-binding protein Staufen homolog {ECO:0000305};
OS Aplysia californica (California sea hare).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Tectipleura; Aplysiida; Aplysioidea;
OC Aplysiidae; Aplysia.
OX NCBI_TaxID=6500 {ECO:0000312|EMBL:AAW84263.1};
RN [1] {ECO:0000312|EMBL:AAW84263.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RX PubMed=16687512; DOI=10.1523/jneurosci.4917-05.2006;
RA Liu J., Hu J.Y., Wu F., Schwartz J.H., Schacher S.;
RT "Two mRNA-binding proteins regulate the distribution of syntaxin mRNA in
RT Aplysia sensory neurons.";
RL J. Neurosci. 26:5204-5214(2006).
RN [2] {ECO:0000312|EMBL:AAO38741.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 278-950.
RX PubMed=17190607; DOI=10.1016/j.cell.2006.09.052;
RA Moroz L.L., Edwards J.R., Puthanveettil S.V., Kohn A.B., Ha T., Heyland A.,
RA Knudsen B., Sahni A., Yu F., Liu L., Jezzini S., Lovell P., Iannucculli W.,
RA Chen M., Nguyen T., Sheng H., Shaw R., Kalachikov S., Panchin Y.V.,
RA Farmerie W., Russo J.J., Ju J., Kandel E.R.;
RT "Neuronal transcriptome of Aplysia: neuronal compartments and circuitry.";
RL Cell 127:1453-1467(2006).
CC -!- FUNCTION: RNA-binding protein which is required for syntaxin location
CC in sensory neurons during long-term synaptic facilitation. Binds to
CC syntaxin mRNA and is required to maintain its accumulation at the axon
CC hillock following neuronal stimulation and at the opposite pole in
CC stable unstimulated sensory neurons. {ECO:0000269|PubMed:16687512}.
CC -!- SUBCELLULAR LOCATION: Perikaryon {ECO:0000269|PubMed:16687512}. Cell
CC projection {ECO:0000269|PubMed:16687512}. Note=Present in both the
CC perikaryon and neurites of sensory neurons. In unstimulated sensory
CC neurons, located in the region of the perikaryon opposite the axon
CC hillock. After neuronal stimulation, expressed at highest levels at the
CC axon hillock. {ECO:0000269|PubMed:16687512}.
CC -!- TISSUE SPECIFICITY: Strongly expressed in nervous tissue (at protein
CC level). {ECO:0000269|PubMed:16687512}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAO38741.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY764181; AAW84263.1; -; mRNA.
DR EMBL; AY172981; AAO38741.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001191404.1; NM_001204475.1.
DR RefSeq; NP_001191656.1; NM_001204727.1.
DR AlphaFoldDB; Q3L1C9; -.
DR SMR; Q3L1C9; -.
DR GeneID; 100533450; -.
DR GeneID; 100533495; -.
DR OrthoDB; 823092at2759; -.
DR GO; GO:0043005; C:neuron projection; IDA:UniProtKB.
DR GO; GO:0043025; C:neuronal cell body; IDA:UniProtKB.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0003729; F:mRNA binding; IDA:UniProtKB.
DR GO; GO:0032880; P:regulation of protein localization; IMP:UniProtKB.
DR CDD; cd19882; DSRM_STAU2_rpt2; 1.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR044464; STAU2_DSRM_2.
DR InterPro; IPR032478; Staufen_C.
DR Pfam; PF00035; dsrm; 3.
DR Pfam; PF16482; Staufen_C; 1.
DR SMART; SM00358; DSRM; 4.
DR PROSITE; PS50137; DS_RBD; 4.
PE 1: Evidence at protein level;
KW Cell projection; Repeat; RNA-binding.
FT CHAIN 1..950
FT /note="Double-stranded RNA-binding protein Staufen homolog"
FT /id="PRO_0000437248"
FT DOMAIN 344..411
FT /note="DRBM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT DOMAIN 435..546
FT /note="DRBM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT DOMAIN 578..645
FT /note="DRBM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT DOMAIN 690..758
FT /note="DRBM 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT REGION 25..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 922..950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..782
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 800..833
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 408
FT /note="E -> G (in Ref. 2; AAO38741)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 950 AA; 105959 MW; A3FB384151B6C773 CRC64;
MSHNHMMNNQ QQHAAMINPG AVASVSGAQV QQRSMMSQQR GGSHAINSSK SPYQLQTSSI
SQFSHLQQQQ QQQQQQQLVN NYHKQKQMSP DITSHQFSSS TGGGMPTQNG NYQSMSGSSI
HTSMGLDNGQ LSLQHQHHQY SSQPAQALQT SVQQHHYQSQ QMTQQQQQAA QQQPQQQYQS
FQQQHHLIQQ QQQQQQIHTQ QQQQLPQQAM HQQQQHLQLH QHLQQRSLNQ QQQQQQRYQK
QQQQPQPKQI LQHSPTSGKS LSSAPHGTSV QPSTLLNHHQ HNMAAPQVTP VTNGESAGED
TSPKDSPQAP KTSGRDSVHV SDNEESASNA SEMQQSLANT KEKTPMCLIN ELARFNKMSH
QYTLVDEQGP AHKKTFYVKL KLGDEEYSAS GESIKKAQHA AAAIALVETK CPHPPPKPAR
LGCCDLEKSA DGNITPTVEL NALAMKRGEP ALYKSIEPQQ PPYYHQPNMD FRGLYNQRYH
QYMRASRDPR YRGNGVLWPL RYHYPRMNRA FYVSLRVGHR EFIGDGPTRQ AARHNAAQKA
LRILKNLPVQ SGEKKSEEQA DEAAEDACEE DVDDSLKSEI SLVHEIALRR NMVVQFEVIR
ETGPPHMKNF LTRCTVADMV TEGEGNSKKT SKKKAAELML EELRKLPPLA TPAFPRPKSK
IQMNKKKNRN LIKSELQQQK ADPNYGVGIN PISRLIQIMQ AQKKKEPVYT LVTERGLPRR
REFIVQVEVE DKTCPGSGPN KKLAKRAAAE AMLQLLGYTK PSPQPTKSSF KNPSTGEAGQ
TNGDKKVTFV GGDSPGDGDD KVSSGSNQQR VPGLLHLPSK SSASSSGNQH TASKESLVNL
ASILKPNLRP EIQLRELCKA MDCQLEIDDF TKKRTSGTEH ITRITIGSEN PQSFHGSNTS
LESSRDMAAL DALKVLVARA KDIHPGGDGP QVKKDVLARS GSGMKKDFSK
