STB4_YEAST
ID STB4_YEAST Reviewed; 949 AA.
AC P50104; D6VZJ3;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Probable transcriptional regulatory protein STB4;
GN Name=STB4; OrderedLocusNames=YMR019W; ORFNames=YM9711.08;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169872;
RA Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL Nature 387:90-93(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP CHARACTERIZATION.
RX PubMed=9393435; DOI=10.1007/s004380050581;
RA Kasten M.M., Stillman D.J.;
RT "Identification of the Saccharomyces cerevisiae genes STB1-STB5 encoding
RT Sin3p binding proteins.";
RL Mol. Gen. Genet. 256:376-386(1997).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Binds to SIN3.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- MISCELLANEOUS: Present with 98 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; Z49211; CAA89121.1; -; Genomic_DNA.
DR EMBL; BK006946; DAA09917.1; -; Genomic_DNA.
DR PIR; S54020; S54020.
DR RefSeq; NP_013732.1; NM_001182515.1.
DR AlphaFoldDB; P50104; -.
DR SMR; P50104; -.
DR BioGRID; 35190; 136.
DR DIP; DIP-2487N; -.
DR IntAct; P50104; 1.
DR MINT; P50104; -.
DR STRING; 4932.YMR019W; -.
DR iPTMnet; P50104; -.
DR MaxQB; P50104; -.
DR PaxDb; P50104; -.
DR PRIDE; P50104; -.
DR EnsemblFungi; YMR019W_mRNA; YMR019W; YMR019W.
DR GeneID; 855033; -.
DR KEGG; sce:YMR019W; -.
DR SGD; S000004621; STB4.
DR VEuPathDB; FungiDB:YMR019W; -.
DR eggNOG; ENOG502RBGV; Eukaryota.
DR HOGENOM; CLU_012010_0_0_1; -.
DR InParanoid; P50104; -.
DR OMA; KAKRIFW; -.
DR BioCyc; YEAST:G3O-32725-MON; -.
DR PRO; PR:P50104; -.
DR Proteomes; UP000002311; Chromosome XIII.
DR RNAct; P50104; protein.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0005634; C:nucleus; ISS:SGD.
DR GO; GO:0003677; F:DNA binding; ISS:SGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; HDA:SGD.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00906; Fungal_trans; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..949
FT /note="Probable transcriptional regulatory protein STB4"
FT /id="PRO_0000114980"
FT DNA_BIND 87..113
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 164..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 862..888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 949 AA; 109825 MW; ED3BF5E26F596CF4 CRC64;
MSINHEIYYI LVFEHRSVAI KLIIVVIVLL QFFLARSRQI DRTWAHTNRK ERFREMTAIG
NTDDALDTST AASKENGKGR LRVQKACELC KKRKVKCDGN NPCLNCSKHQ KECRYDFKAT
NRKRRRRQVA SAVRDVSKTY AETSESFPRD LLSKSNIIIN APSDGVSSSA SNSPNPNSHY
HHISSTLPFM SGRPNHTFHS GSNLNGENNN NSFPEDHMAK LLLQLSSKLG NTTKESSIRT
TRTNASDVNA NPTVVNMKNS QEDCDTNHRS AICDSAEALH NNNINSKENK IINSQITNTV
NDHFESPWQT FSLDKYRFHR RYQNILPYYL GVSILKDLSP QTIEYAKLKR PRVQNYGWNL
SGGHYLKYKG DFRSQEKNIR HESKFFDFDD PVHLSLINKL LRYYFDEINP VFSIIHEATF
WQQYNNKFLR QGKQNNSSAN LFTSMLYLIL STTLRFREGH LDGQKGQGTY SNTSLNITFE
EKSILIKKPS IEENLFKYAY LIINTLTFEW ESFELIQSWL LITFYFRTCY RQTACWNALS
QAVNMCNGMS LYLNKFPEIH STYDESKAWH CFWCCFIMDK LISFQMGRFY QLSLPASEMC
EQMNLVKSKK FLQEEDDWFH EETFQMLDLS IIVTQFLKRD AQDLNLNETV QLRSQLGQWY
DTFIVGSQTN AYDDNYRYFY QVQPFMTYLD IRLTFEVRQL FCLIAPSSTA NNKSLEYVVD
TELLISHCQM AIENLAEITR SNLFFVPWWL NLSQLFTVNL ICIIYLHAGI AVTQNKAIMQ
SCQEIWRTLE CSKPKNRPSM LPECLWCLKM LNHMFCIRLR DSALQLEATL GTDHGDDTPN
RNKFEQFKKV GDNDADVEVD AGEREENADE RQENPHNNSK RVPLATRSHN TTNFDGSIAI
SPESAVANLG TDTGLPSDVL DTVSKIGNSP NVFDDDLFSN LLWFDQNFA
