STB5L_DANRE
ID STB5L_DANRE Reviewed; 1159 AA.
AC Q5SQE2;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Syntaxin-binding protein 5-like;
GN Name=stxbp5l; ORFNames=si:ch211-194d6.1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- FUNCTION: May play a role in vesicle trafficking and exocytosis.
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cell membrane
CC {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Membrane
CC {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
CC Note=Cytoplasmic, and associated with vesicular membranes and the
CC plasma membrane. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the WD repeat L(2)GL family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL772198; CAI11695.1; -; Genomic_DNA.
DR EMBL; BX322637; CAI11695.1; JOINED; Genomic_DNA.
DR EMBL; BX322637; CAI20992.1; -; Genomic_DNA.
DR EMBL; AL772198; CAI20992.1; JOINED; Genomic_DNA.
DR RefSeq; NP_001038602.1; NM_001045137.1.
DR AlphaFoldDB; Q5SQE2; -.
DR SMR; Q5SQE2; -.
DR STRING; 7955.ENSDARP00000027152; -.
DR PaxDb; Q5SQE2; -.
DR Ensembl; ENSDART00000017292; ENSDARP00000027152; ENSDARG00000006383.
DR GeneID; 567605; -.
DR KEGG; dre:567605; -.
DR CTD; 9515; -.
DR ZFIN; ZDB-GENE-041210-220; stxbp5l.
DR eggNOG; KOG1983; Eukaryota.
DR GeneTree; ENSGT00950000182906; -.
DR HOGENOM; CLU_002808_0_0_1; -.
DR InParanoid; Q5SQE2; -.
DR OMA; PNXFPIF; -.
DR OrthoDB; 84844at2759; -.
DR PhylomeDB; Q5SQE2; -.
DR TreeFam; TF314585; -.
DR PRO; PR:Q5SQE2; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 9.
DR Bgee; ENSDARG00000006383; Expressed in brain and 5 other tissues.
DR ExpressionAtlas; Q5SQE2; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0045159; F:myosin II binding; IBA:GO_Central.
DR GO; GO:0019905; F:syntaxin binding; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0017157; P:regulation of exocytosis; IBA:GO_Central.
DR GO; GO:0050708; P:regulation of protein secretion; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR000664; Lethal2_giant.
DR InterPro; IPR013577; LLGL2.
DR InterPro; IPR042855; V_SNARE_CC.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF08366; LLGL; 1.
DR Pfam; PF00400; WD40; 1.
DR PRINTS; PR00962; LETHAL2GIANT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 2.
DR PROSITE; PS50892; V_SNARE; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cell membrane; Coiled coil; Cytoplasm; Exocytosis; Membrane;
KW Protein transport; Reference proteome; Repeat; Transport; WD repeat.
FT CHAIN 1..1159
FT /note="Syntaxin-binding protein 5-like"
FT /id="PRO_0000051249"
FT REPEAT 67..108
FT /note="WD 1"
FT REPEAT 115..154
FT /note="WD 2"
FT REPEAT 159..195
FT /note="WD 3"
FT REPEAT 214..248
FT /note="WD 4"
FT REPEAT 254..286
FT /note="WD 5"
FT REPEAT 307..350
FT /note="WD 6"
FT REPEAT 358..392
FT /note="WD 7"
FT REPEAT 414..491
FT /note="WD 8"
FT REPEAT 519..628
FT /note="WD 9"
FT REPEAT 642..703
FT /note="WD 10"
FT REPEAT 808..865
FT /note="WD 11"
FT REPEAT 874..946
FT /note="WD 12"
FT REPEAT 951..995
FT /note="WD 13"
FT REPEAT 1009..1032
FT /note="WD 14"
FT DOMAIN 1094..1154
FT /note="v-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 690..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..718
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 725..740
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1159 AA; 128203 MW; F823DC2FB1DDC666 CRC64;
MKKFRKVLDG LTTSSPVNPG GSPGCGSAAG TPSAAPTPRE LEIQETLMSE HFQICKTVRH
GFPYQPTALA FDPVQKILAI GSRSGGIRMY PFLSFPHLGR PGVDCHSQHE SGAAVLQMQF
LINEGALVTA CADDTLHLWS LRQRLPAILH SLKFNRERIT FCHLPFQSKW LYVGTERGNT
HIVNIESFIL SGYVIMWNKA IELSTKTHPG PVVHLSDSPK DEGKLLIGFE SGTIVMWDLR
AKRADFRIYY DEAIHSVSWH HEGRQFMCSH SDGSLSMWNM RNTAKPFQVT FPHGKTQRDG
RKESCKPILK VEYKTSRNSS EAFVIFSGGL SYDKAGRRPT LTIMHGKAIT VLEMDYPIVD
FMVLCETPYL NEVQEPYAVV VLLEKDFVVV DLTQSNFPIF ENPYPMDVHE SPVTCTAYFA
DCPPDIIPVL YSIGAKHKKT GYSHKEWPVS GGTWTVGSQT YPEIIITGHA DGSIKFWDAT
AITLQMLYKL KTSKVFEKPK TGDMGRSADL VEEDPYAVQM ISWCPQSRIF CVVGISAHVI
LYRFSKHDAN TIITSLELRL QCEMEDVISP SDTENTPCFS DPSGHSPQPQ PPSPRSNTPD
SVRDSIPCLK VKDRMIRMPP GYQAELVVQL LWVDGEPPQQ ITCLDLNSAY GLLALGNCNG
LAVVDYLQKT ILLCMSTLEL YGSADPFQRL TRSPRKNRQS TSGLTELSDN QVSLDLERSK
SPTSDHVNGH CTSPTSQPCP SGRARVPGGP EGPRLARRGP GRPPFRKAQS AACMEVSLPV
SSLTEENSFS RSRSSSVSSI DRETKEAVTT LQFAESYGRK SDSLPTPCLW VGTSLGLVLI
IPMSIPTDEQ ERQEDPVTVA PTGTVLMLKG SVLRFGFLDC GGALINSPYE VWRDQHAPDD
PDRPRKRKLV NFSPSSSQEA CGDGHLAVVC SERQAKVFYM PSQACLYVHN ITESSFVLRA
DVVSVSNSVC LACFCANGHI MILSLPSLRP LLDVSYLPLT DMRIARTFCF TNGGQALYLC
SPTEIQRITY SQEMCETLGE LFTPIETPEA QNRGFLKGFF GGNAQTFDRE ELFGEASAGK
ASRSLAQHIP GQGGIEGMKA AAGGVVGDLA RARIALDERG QRLGELEERT ALMMTSAETF
SKHAHELMLK CKDKKWYQF
