STB5_CANGA
ID STB5_CANGA Reviewed; 1005 AA.
AC Q6FQY1;
DT 12-SEP-2018, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=Negative regulator of pleiotropic drug resistance STB5 {ECO:0000303|PubMed:23229483};
GN Name=STB5 {ECO:0000303|PubMed:23229483}; OrderedLocusNames=CAGL0I02552g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
RN [2]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=23229483; DOI=10.1128/aac.01278-12;
RA Noble J.A., Tsai H.F., Suffis S.D., Su Q., Myers T.G., Bennett J.E.;
RT "STB5 is a negative regulator of azole resistance in Candida glabrata.";
RL Antimicrob. Agents Chemother. 57:959-967(2013).
CC -!- FUNCTION: Transcription factor that negatively regulates pleiotropic
CC drug resistance genes, including the ABC transporter genes CDR1, PDH1,
CC and YOR1. {ECO:0000269|PubMed:23229483}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC -!- DISRUPTION PHENOTYPE: Causes a modest increase in azole resistance but
CC does not exhibit altered susceptibility to cycloheximide or caffeine.
CC {ECO:0000269|PubMed:23229483}.
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DR EMBL; CR380955; CAG60300.1; -; Genomic_DNA.
DR RefSeq; XP_447363.1; XM_447363.1.
DR AlphaFoldDB; Q6FQY1; -.
DR STRING; 5478.XP_447363.1; -.
DR EnsemblFungi; CAG60300; CAG60300; CAGL0I02552g.
DR GeneID; 2888916; -.
DR KEGG; cgr:CAGL0I02552g; -.
DR CGD; CAL0132714; STB5.
DR VEuPathDB; FungiDB:CAGL0I02552g; -.
DR eggNOG; ENOG502QTEH; Eukaryota.
DR HOGENOM; CLU_011881_0_0_1; -.
DR InParanoid; Q6FQY1; -.
DR OMA; NNVDVSW; -.
DR Proteomes; UP000002428; Chromosome I.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:2001039; P:negative regulation of cellular response to drug; IMP:CGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:CGD.
DR GO; GO:0043619; P:regulation of transcription from RNA polymerase II promoter in response to oxidative stress; IEA:EnsemblFungi.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:EnsemblFungi.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:EnsemblFungi.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00906; Fungal_trans; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..1005
FT /note="Negative regulator of pleiotropic drug resistance
FT STB5"
FT /id="PRO_0000445082"
FT DNA_BIND 32..59
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 666..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 763..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 673..692
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..777
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1005 AA; 113377 MW; 82013B29978F65AF CRC64;
MSGPDKGSDS GQTANDPKQK KARNGQMETY SCARCRKLKK KCPRQLPECS NCLKAREPCN
YPGRAPRRTK KELRDAIMKG EVLPSMRRKH RKIEKELKTA DLRHLESVDD RPVNQVMGGS
MPPLGAYRGG EQQYNNGPPI SGIDGNDSIN RGKAQSVGSY QILPPQRKSK LVLDQNPKFV
HSQSSALKTN EYPVPIMSPH IANQVYPEGV SSLISALNTM NDNVSANTPI ALSYLQLQKL
HQEQQQIQQQ QIQQQQQHQH LVQQHLQHVR ADATSILPPV TSQTVYTPIP GPRTSQIPFG
FTHGYTASAP PPLMQPYSMP TSPFESREKQ QQFDNIQYHP VYKIPPIAAR QSPIDEIIGI
ENGSISIDAG SITREVVNSR MKGPHSTSWV NEDGSPKPIK KSLLEKFVSA YFEHNHRLFP
MVDKVTFLKK LATINSFESI EMLAVNNPEL PKTFIFEIYM IMAIGCTTLQ RAGKLTTDEG
HLYEHLAYLA MRNFRDILHQ QDITTLRCLI LLGIYSFFEP KGVSSWTISG IAMRLAIELG
LNRPLTAKEM GDMSAVEVES RYRVFWSAYC FERVVATSLG RVSAIDDEDI GIPLPRALYD
SEKEDIEVTN LIISLRKMGG KIYKEVHSLS AGRKDITMEQ KQLIIQKLRK ELDDIYEEEC
EKRRLKGKSR SSKRFEKSKE SDSDRGVTEE DVKSGNENLI GLLASDDVSM TEHGQSIDNT
LESTPLPTTI PTTIVNDSVD QHSTLENIPT SATSKDQIET IITKPTANIM NDQTDSDPLP
KVDNKPISNN EEGPKSLKEG NSEQNPSENI SPEDVTLTKT DNSENKESSL RSNSNISFHI
SNVWLEMRYT QLQILLYRPS ALIPKPPIES LTVLGEFCLA AWRHTYTLYK EKLLPLNWIT
LFRTLTICNT ILYCLCQWSI DLVASTIEIQ QCVEILQHFG EKWVFAMKCA DVFQNISNTI
VEISLSQGQD PNIDKLTREL FGASNAYLEI LNENNVDVSW EDRFR
