STB5_YEAST
ID STB5_YEAST Reviewed; 743 AA.
AC P38699; D3DLC7;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Protein STB5;
GN Name=STB5; OrderedLocusNames=YHR178W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091229; DOI=10.1126/science.8091229;
RA Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA Waterston R., Wilson R., Vaudin M.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT VIII.";
RL Science 265:2077-2082(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9393435; DOI=10.1007/s004380050581;
RA Kasten M.M., Stillman D.J.;
RT "Identification of the Saccharomyces cerevisiae genes STB1-STB5 encoding
RT Sin3p binding proteins.";
RL Mol. Gen. Genet. 256:376-386(1997).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
CC -!- FUNCTION: Binds to SIN3.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- MISCELLANEOUS: Present with 279 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; U00027; AAB68023.1; -; Genomic_DNA.
DR EMBL; BK006934; DAA06871.1; -; Genomic_DNA.
DR PIR; S48917; S48917.
DR RefSeq; NP_012048.3; NM_001179309.3.
DR AlphaFoldDB; P38699; -.
DR SMR; P38699; -.
DR BioGRID; 36611; 674.
DR DIP; DIP-827N; -.
DR IntAct; P38699; 3.
DR MINT; P38699; -.
DR STRING; 4932.YHR178W; -.
DR iPTMnet; P38699; -.
DR MaxQB; P38699; -.
DR PaxDb; P38699; -.
DR PRIDE; P38699; -.
DR EnsemblFungi; YHR178W_mRNA; YHR178W; YHR178W.
DR GeneID; 856583; -.
DR KEGG; sce:YHR178W; -.
DR SGD; S000001221; STB5.
DR VEuPathDB; FungiDB:YHR178W; -.
DR eggNOG; ENOG502QTEH; Eukaryota.
DR GeneTree; ENSGT00940000176581; -.
DR HOGENOM; CLU_011881_0_0_1; -.
DR InParanoid; P38699; -.
DR OMA; NNVDVSW; -.
DR BioCyc; YEAST:G3O-31211-MON; -.
DR PRO; PR:P38699; -.
DR Proteomes; UP000002311; Chromosome VIII.
DR RNAct; P38699; protein.
DR GO; GO:0005634; C:nucleus; IC:SGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:SGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; HDA:SGD.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0043619; P:regulation of transcription from RNA polymerase II promoter in response to oxidative stress; IMP:SGD.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IMP:SGD.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IDA:SGD.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00906; Fungal_trans; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..743
FT /note="Protein STB5"
FT /id="PRO_0000114978"
FT DNA_BIND 22..49
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 81..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..100
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 743 AA; 83473 MW; F1777001EA3E0432 CRC64;
MDGPNFAHQG GRSQRTTELY SCARCRKLKK KCGKQIPTCA NCDKNGAHCS YPGRAPRRTK
KELADAMLRG EYVPVKRNKK VGKSPLSTKS MPNSSSPLSA NGAITPGFSP YENDDAHKMK
QLKPSDPINL VMGASPNSSE GVSSLISVLT SLNDNSNPSS HLSSNENSMI PSRSLPASVQ
QSSTTSSFGG YNTPSPLISS HVPANAQAVP LQNNNRNTSN GDNGSNVNHD NNNGSTNTPQ
LSLTPYANNS APNGKFDSVP VDASSIEFET MSCCFKGGRT TSWVREDGSF KSIDRSLLDR
FIAAYFKHNH RLFPMIDKIA FLNDAATITD FERLYDNKNY PDSFVFKVYM IMAIGCTTLQ
RAGMVSQDEE CLSEHLAFLA MKKFRSVIIL QDIETVRCLL LLGIYSFFEP KGSSSWTISG
IIMRLTIGLG LNRELTAKKL KSMSALEAEA RYRVFWSAYC FERLVCTSLG RISGIDDEDI
TVPLPRALYV DERDDLEMTK LMISLRKMGG RIYKQVHSVS AGRQKLTIEQ KQEIISGLRK
ELDEIYSRES ERRKLKKSQM DQVERENNST TNVISFHSSE IWLAMRYSQL QILLYRPSAL
MPKPPIDSLS TLGEFCLQAW KHTYTLYKKR LLPLNWITLF RTLTICNTIL YCLCQWSIDL
IESKIEIQQC VEILRHFGER WIFAMRCADV FQNISNTILD ISLSHGKVPN MDQLTRELFG
ASDSYQDILD ENNVDVSWVD KLV
