STB6_YEAST
ID STB6_YEAST Reviewed; 766 AA.
AC P36085; D6VXL4;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Protein STB6;
GN Name=STB6; OrderedLocusNames=YKL072W; ORFNames=YKL352;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091863; DOI=10.1002/yea.320100009;
RA Rasmussen S.W.;
RT "Sequence of a 20.7 kb region of yeast chromosome XI includes the NUP100
RT gene, an open reading frame (ORF) possibly representing a nucleoside
RT diphosphate kinase gene, tRNAs for His, Val and Trp in addition to seven
RT ORFs with weak or no significant similarity to known proteins.";
RL Yeast 10:S69-S74(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8196765; DOI=10.1038/369371a0;
RA Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V.,
RA Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P.,
RA Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L.,
RA Daignan-Fornier B., del Rey F., Dion C., Domdey H., Duesterhoeft A.,
RA Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H.,
RA Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L.,
RA Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M.,
RA Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H.,
RA Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J.,
RA Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H.,
RA Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J.,
RA Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S.,
RA Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F.,
RA Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R.,
RA Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W.,
RA Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M.,
RA Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C.,
RA Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H.,
RA Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L.,
RA van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S.,
RA von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M.,
RA Becker I., Mewes H.-W.;
RT "Complete DNA sequence of yeast chromosome XI.";
RL Nature 369:371-378(1994).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP CHARACTERIZATION.
RX PubMed=9393435; DOI=10.1007/s004380050581;
RA Kasten M.M., Stillman D.J.;
RT "Identification of the Saccharomyces cerevisiae genes STB1-STB5 encoding
RT Sin3p binding proteins.";
RL Mol. Gen. Genet. 256:376-386(1997).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-514, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-514, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19779198; DOI=10.1126/science.1172867;
RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT into evolution.";
RL Science 325:1682-1686(2009).
CC -!- FUNCTION: Binds to SIN3.
CC -!- MISCELLANEOUS: Present with 211 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: To yeast STB2. {ECO:0000305}.
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DR EMBL; X75780; CAA53402.1; -; Genomic_DNA.
DR EMBL; Z28072; CAA81909.1; -; Genomic_DNA.
DR EMBL; BK006944; DAA09084.1; -; Genomic_DNA.
DR PIR; S37894; S37894.
DR RefSeq; NP_012851.1; NM_001179638.1.
DR AlphaFoldDB; P36085; -.
DR BioGRID; 34059; 40.
DR DIP; DIP-2488N; -.
DR IntAct; P36085; 6.
DR MINT; P36085; -.
DR STRING; 4932.YKL072W; -.
DR iPTMnet; P36085; -.
DR MaxQB; P36085; -.
DR PaxDb; P36085; -.
DR PRIDE; P36085; -.
DR EnsemblFungi; YKL072W_mRNA; YKL072W; YKL072W.
DR GeneID; 853790; -.
DR KEGG; sce:YKL072W; -.
DR SGD; S000001555; STB6.
DR VEuPathDB; FungiDB:YKL072W; -.
DR eggNOG; ENOG502QT8Q; Eukaryota.
DR GeneTree; ENSGT00940000176579; -.
DR HOGENOM; CLU_010065_0_0_1; -.
DR InParanoid; P36085; -.
DR OMA; IYTFQKK; -.
DR BioCyc; YEAST:G3O-31868-MON; -.
DR PRO; PR:P36085; -.
DR Proteomes; UP000002311; Chromosome XI.
DR RNAct; P36085; protein.
DR GO; GO:0070822; C:Sin3-type complex; IBA:GO_Central.
DR InterPro; IPR038919; Stb2/Stb6.
DR PANTHER; PTHR31011; PTHR31011; 2.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..766
FT /note="Protein STB6"
FT /id="PRO_0000072255"
FT REGION 447..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 514
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18407956,
FT ECO:0007744|PubMed:19779198"
SQ SEQUENCE 766 AA; 88836 MW; 9BCBEA2EE03A9AF1 CRC64;
MQLEATHQKE NHLSPLASFI FPDFRALFNI GFNLYSNINY KEVDINGFEI YIVEQWAAQR
KISTLITSYT GNLQDTISAV EVALPEDPEE WPCCLKKYHE ELLKFSSPKK TAKGTLFVTN
LSSFKSTLNL LHVECGNLKK IWKNFKTNYD LKRLHCGGRS AQLLKKTPSA SIAKFAQLYK
FPNSAFSHEI TSDFQQPSLQ NDNSSISSIE NIPVNHCPVV ELTTLVQISL SYFALFEYKK
ERDGLLCNGT KQSLEKWWEI YGKRYHGIDK PKNETILGPT TVASLLSLVL TCYFKLMVED
CMSAKDPFDE EEFYSGLYAF QKKYGLSKNN KQTSLDELTI DKLFEVSSKT SNKDIFKFKK
VVKSTVQDMT GKGNFMHLSN EILTTDLDTL VKNIHGGSLG KLWKGRSASR KETCMVWERK
TFLSFKFERG DPSLQLENNE LFYGTSVPSE QLTTSNKEDS DTQPTKRNSI YDIANGSKSS
LSISSMFCNY DETRYKSTNN LNRAYRGEYF RRNSIPFCND GIHDTKKISA DLNKIDGLYR
CNSYSEVQNA IELWSLPFDS SVIRLARDLL KIQSLMSVQR QLDEIRDGYL GKNSQRSYQN
DLMFRQSLNK LQEMCERCKR GSNEFHWEYG NMQNKQQILE SEKKDMKSLS SKLKYNVRIL
DRRVRDVEAS VDHFDRKLED VRKKLLEQNN SKDISMALES PCDKFEFDSF MDSIVQSQQT
KYEGLCFKIL DKKSLRKLKK EFWKWSTWTF DTFLYKNRPN KEKDTL
