STC1_BOVIN
ID STC1_BOVIN Reviewed; 247 AA.
AC Q9N0T1; A5D9D9; Q2KJA8;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Stanniocalcin-1;
DE Short=STC-1;
DE Flags: Precursor;
GN Name=STC1; Synonyms=STC;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Ovary;
RA DiMattia G.E.;
RT "Bovine stanniocalcin cDNA sequence.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Heart ventricle;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Stimulates renal phosphate reabsorption, and could therefore
CC prevent hypercalcemia. {ECO:0000250}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the stanniocalcin family. {ECO:0000305}.
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DR EMBL; AF257506; AAF68996.1; -; mRNA.
DR EMBL; BT030558; ABQ12998.1; -; mRNA.
DR EMBL; BC105435; AAI05436.1; -; mRNA.
DR RefSeq; NP_788842.2; NM_176669.3.
DR AlphaFoldDB; Q9N0T1; -.
DR STRING; 9913.ENSBTAP00000002200; -.
DR PaxDb; Q9N0T1; -.
DR PRIDE; Q9N0T1; -.
DR Ensembl; ENSBTAT00000002200; ENSBTAP00000002200; ENSBTAG00000001687.
DR GeneID; 338078; -.
DR KEGG; bta:338078; -.
DR CTD; 6781; -.
DR VEuPathDB; HostDB:ENSBTAG00000001687; -.
DR VGNC; VGNC:35377; STC1.
DR eggNOG; ENOG502QU7E; Eukaryota.
DR GeneTree; ENSGT00390000005989; -.
DR HOGENOM; CLU_064102_1_1_1; -.
DR InParanoid; Q9N0T1; -.
DR OMA; RMITEVQ; -.
DR OrthoDB; 1019934at2759; -.
DR TreeFam; TF324693; -.
DR Proteomes; UP000009136; Chromosome 8.
DR Bgee; ENSBTAG00000001687; Expressed in intramuscular adipose tissue and 98 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR GO; GO:0035988; P:chondrocyte proliferation; IEA:Ensembl.
DR GO; GO:0001886; P:endothelial cell morphogenesis; IEA:Ensembl.
DR GO; GO:0003421; P:growth plate cartilage axis specification; IEA:Ensembl.
DR GO; GO:0051926; P:negative regulation of calcium ion transport; IEA:Ensembl.
DR GO; GO:0010596; P:negative regulation of endothelial cell migration; IEA:Ensembl.
DR GO; GO:1903403; P:negative regulation of renal phosphate excretion; IEA:Ensembl.
DR GO; GO:0090280; P:positive regulation of calcium ion import; IEA:Ensembl.
DR GO; GO:0044070; P:regulation of anion transport; IEA:Ensembl.
DR GO; GO:0086004; P:regulation of cardiac muscle cell contraction; IEA:Ensembl.
DR InterPro; IPR004978; Stanniocalcin.
DR PANTHER; PTHR11245; PTHR11245; 1.
DR Pfam; PF03298; Stanniocalcin; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..247
FT /note="Stanniocalcin-1"
FT /id="PRO_0000033296"
FT CARBOHYD 24
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 45..59
FT /evidence="ECO:0000250"
FT DISULFID 54..74
FT /evidence="ECO:0000250"
FT DISULFID 65..114
FT /evidence="ECO:0000250"
FT DISULFID 98..128
FT /evidence="ECO:0000250"
FT DISULFID 135..170
FT /evidence="ECO:0000250"
FT DISULFID 202
FT /note="Interchain"
FT /evidence="ECO:0000250"
FT CONFLICT 8
FT /note="L -> I (in Ref. 1; AAF68996)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 247 AA; 27555 MW; 42F99CA9E8F15057 CRC64;
MLQNSAVLLV LVISASATHE AEQNDSVSLR KSRVAAQNSA EVIRCLNSAL QVGCGAFACL
ENSTCDTDGM YDICKSFLYS AAKFDTQGKA FVKESLKCIA NGVTSKVFLA IRRCSTFQRM
IAEVQEECYT KLNVCSVAKR NPEAITEVVQ LPNHFSNRYY NRLVRSLLDC DEDTVSTIRD
SLMEKIGPNM ASLFHILQTD HCAHTQQRAD FNRRRANEPQ KLKVLLRNLR GEVASPSHIK
RTSQESA
