STC1_MOUSE
ID STC1_MOUSE Reviewed; 247 AA.
AC O55183;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Stanniocalcin-1;
DE Short=STC-1;
DE Flags: Precursor;
GN Name=Stc1; Synonyms=Stc;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RX PubMed=9027337; DOI=10.1016/s0303-7207(96)03929-9;
RA Chang A.C.-M., Dunham M.A., Jeffrey K.J., Reddel R.R.;
RT "Molecular cloning and characterization of mouse stanniocalcin cDNA.";
RL Mol. Cell. Endocrinol. 124:185-187(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Stimulates renal phosphate reabsorption, and could therefore
CC prevent hypercalcemia. {ECO:0000250}.
CC -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in many tissues.
CC -!- SIMILARITY: Belongs to the stanniocalcin family. {ECO:0000305}.
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DR EMBL; U47815; AAC00050.1; -; Genomic_DNA.
DR EMBL; BC021425; AAH21425.1; -; mRNA.
DR CCDS; CCDS27236.1; -.
DR RefSeq; NP_033311.3; NM_009285.3.
DR AlphaFoldDB; O55183; -.
DR STRING; 10090.ENSMUSP00000014957; -.
DR GlyGen; O55183; 1 site.
DR iPTMnet; O55183; -.
DR PhosphoSitePlus; O55183; -.
DR PaxDb; O55183; -.
DR PRIDE; O55183; -.
DR ProteomicsDB; 257487; -.
DR Antibodypedia; 9801; 411 antibodies from 37 providers.
DR DNASU; 20855; -.
DR Ensembl; ENSMUST00000014957; ENSMUSP00000014957; ENSMUSG00000014813.
DR GeneID; 20855; -.
DR KEGG; mmu:20855; -.
DR UCSC; uc007ulz.1; mouse.
DR CTD; 6781; -.
DR MGI; MGI:109131; Stc1.
DR VEuPathDB; HostDB:ENSMUSG00000014813; -.
DR eggNOG; ENOG502QU7E; Eukaryota.
DR GeneTree; ENSGT00390000005989; -.
DR HOGENOM; CLU_064102_1_1_1; -.
DR InParanoid; O55183; -.
DR OMA; RMITEVQ; -.
DR OrthoDB; 1019934at2759; -.
DR PhylomeDB; O55183; -.
DR TreeFam; TF324693; -.
DR BioGRID-ORCS; 20855; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Stc1; mouse.
DR PRO; PR:O55183; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; O55183; protein.
DR Bgee; ENSMUSG00000014813; Expressed in dorsal horn of spinal cord and 206 other tissues.
DR ExpressionAtlas; O55183; baseline and differential.
DR Genevisible; O55183; MM.
DR GO; GO:0016324; C:apical plasma membrane; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0005179; F:hormone activity; TAS:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0060348; P:bone development; ISO:MGI.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; ISO:MGI.
DR GO; GO:0030320; P:cellular monovalent inorganic anion homeostasis; TAS:MGI.
DR GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR GO; GO:0071385; P:cellular response to glucocorticoid stimulus; IEA:Ensembl.
DR GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
DR GO; GO:0035988; P:chondrocyte proliferation; ISO:MGI.
DR GO; GO:0046697; P:decidualization; IEA:Ensembl.
DR GO; GO:0007566; P:embryo implantation; IEA:Ensembl.
DR GO; GO:0001886; P:endothelial cell morphogenesis; ISO:MGI.
DR GO; GO:0003421; P:growth plate cartilage axis specification; ISO:MGI.
DR GO; GO:0051926; P:negative regulation of calcium ion transport; ISO:MGI.
DR GO; GO:0030336; P:negative regulation of cell migration; ISO:MGI.
DR GO; GO:0010596; P:negative regulation of endothelial cell migration; ISO:MGI.
DR GO; GO:1903403; P:negative regulation of renal phosphate excretion; ISO:MGI.
DR GO; GO:0001503; P:ossification; ISO:MGI.
DR GO; GO:0090280; P:positive regulation of calcium ion import; ISO:MGI.
DR GO; GO:0044070; P:regulation of anion transport; ISO:MGI.
DR GO; GO:0086004; P:regulation of cardiac muscle cell contraction; ISO:MGI.
DR GO; GO:0033280; P:response to vitamin D; IEA:Ensembl.
DR InterPro; IPR004978; Stanniocalcin.
DR PANTHER; PTHR11245; PTHR11245; 1.
DR Pfam; PF03298; Stanniocalcin; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT PROPEP 19..33
FT /evidence="ECO:0000255"
FT /id="PRO_0000033299"
FT CHAIN 34..247
FT /note="Stanniocalcin-1"
FT /id="PRO_0000033300"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 45..59
FT /evidence="ECO:0000250"
FT DISULFID 54..74
FT /evidence="ECO:0000250"
FT DISULFID 65..114
FT /evidence="ECO:0000250"
FT DISULFID 98..128
FT /evidence="ECO:0000250"
FT DISULFID 135..170
FT /evidence="ECO:0000250"
FT DISULFID 202
FT /note="Interchain"
FT /evidence="ECO:0000250"
SQ SEQUENCE 247 AA; 27480 MW; DAD30D08575A513B CRC64;
MLQNSAVILA LVISAAAAHE AEQNDSVSPR KSRVAAQNSA EVVRCLNSAL QVGCGAFACL
ENSTCDTDGM YDICKSFLYS AAKFDTQGKA FVKESLKCIA NGITSKVFLA IRRCSTFQRM
IAEVQEDCYS KLNVCSIAKR NPEAITEVIQ LPNHFSNRYY NRLVRSLLEC DEDTVSTIRD
SLMEKIGPNM ASLFHILQTD HCAQTHPRAD FNRRRTNEPQ KLKVLLRNLR GEGDSPSHIK
RTSQESA
