ID   STC1_RAT                Reviewed;         247 AA.
AC   P97574;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Stanniocalcin-1;
DE            Short=STC-1;
DE   Flags: Precursor;
GN   Name=Stc1; Synonyms=Stc;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Kidney;
RA   Abe T., Tanemoto M., Hall A.E., Brown E.M., Hebert S.C.;
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Stimulates renal phosphate reabsorption, and could therefore
CC       prevent hypercalcemia. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the stanniocalcin family. {ECO:0000305}.
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DR   EMBL; U62667; AAB39541.1; -; mRNA.
DR   EMBL; BC078803; AAH78803.1; -; mRNA.
DR   RefSeq; NP_112385.1; NM_031123.2.
DR   AlphaFoldDB; P97574; -.
DR   STRING; 10116.ENSRNOP00000020728; -.
DR   GlyGen; P97574; 1 site.
DR   PaxDb; P97574; -.
DR   PRIDE; P97574; -.
DR   Ensembl; ENSRNOT00000020728; ENSRNOP00000020728; ENSRNOG00000015075.
DR   GeneID; 81801; -.
DR   KEGG; rno:81801; -.
DR   UCSC; RGD:621776; rat.
DR   CTD; 6781; -.
DR   RGD; 621776; Stc1.
DR   eggNOG; ENOG502QU7E; Eukaryota.
DR   GeneTree; ENSGT00390000005989; -.
DR   HOGENOM; CLU_064102_1_1_1; -.
DR   InParanoid; P97574; -.
DR   OMA; RMITEVQ; -.
DR   OrthoDB; 1019934at2759; -.
DR   PhylomeDB; P97574; -.
DR   TreeFam; TF324693; -.
DR   PRO; PR:P97574; -.
DR   Proteomes; UP000002494; Chromosome 15.
DR   Bgee; ENSRNOG00000015075; Expressed in kidney and 18 other tissues.
DR   Genevisible; P97574; RN.
DR   GO; GO:0016324; C:apical plasma membrane; IDA:RGD.
DR   GO; GO:0005737; C:cytoplasm; IDA:RGD.
DR   GO; GO:0005615; C:extracellular space; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   GO; GO:0060348; P:bone development; ISO:RGD.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; ISO:RGD.
DR   GO; GO:0071320; P:cellular response to cAMP; IEP:RGD.
DR   GO; GO:0071385; P:cellular response to glucocorticoid stimulus; IEP:RGD.
DR   GO; GO:0071456; P:cellular response to hypoxia; IEP:RGD.
DR   GO; GO:0035988; P:chondrocyte proliferation; ISO:RGD.
DR   GO; GO:0046697; P:decidualization; IEP:RGD.
DR   GO; GO:0007566; P:embryo implantation; IEP:RGD.
DR   GO; GO:0001886; P:endothelial cell morphogenesis; ISO:RGD.
DR   GO; GO:0003421; P:growth plate cartilage axis specification; ISO:RGD.
DR   GO; GO:0051926; P:negative regulation of calcium ion transport; ISO:RGD.
DR   GO; GO:0030336; P:negative regulation of cell migration; ISO:RGD.
DR   GO; GO:0010596; P:negative regulation of endothelial cell migration; ISO:RGD.
DR   GO; GO:1903403; P:negative regulation of renal phosphate excretion; ISO:RGD.
DR   GO; GO:0001503; P:ossification; IDA:RGD.
DR   GO; GO:0090280; P:positive regulation of calcium ion import; ISO:RGD.
DR   GO; GO:0044070; P:regulation of anion transport; ISO:RGD.
DR   GO; GO:0086004; P:regulation of cardiac muscle cell contraction; ISO:RGD.
DR   GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
DR   GO; GO:0033280; P:response to vitamin D; IEP:RGD.
DR   InterPro; IPR004978; Stanniocalcin.
DR   PANTHER; PTHR11245; PTHR11245; 1.
DR   Pfam; PF03298; Stanniocalcin; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..33
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000033301"
FT   CHAIN           34..247
FT                   /note="Stanniocalcin-1"
FT                   /id="PRO_0000033302"
FT   CARBOHYD        62
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        45..59
FT                   /evidence="ECO:0000250"
FT   DISULFID        54..74
FT                   /evidence="ECO:0000250"
FT   DISULFID        65..114
FT                   /evidence="ECO:0000250"
FT   DISULFID        98..128
FT                   /evidence="ECO:0000250"
FT   DISULFID        135..170
FT                   /evidence="ECO:0000250"
FT   DISULFID        202
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   247 AA;  27507 MW;  DAC2FD08575A513B CRC64;
     MLQNSAVILA LVISAAAAHE AEQNDSVSPR KSRVAAQNSA EVVRCLNSAL QVGCGAFACL
     ENSTCDTDGM YDICKSFLYS AAKFDTQGKA FVKESLKCIA NGITSKVFLA IRRCSTFQRM
     IAEVQEDCYS KLNVCSIAKR NPEAITEVIQ LPNHFSNRYY NRLVRSLLEC DEDTVSTIRD
     SLMEKIGPNM ASLFHILQTD HCAQTHPRAD FNRRRTNEPQ KLKVLLRNLR GEGDSPSHIK
     RTSQENA