ID   STC2_MACNE              Reviewed;         302 AA.
AC   O97561;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Stanniocalcin-2;
DE            Short=STC-2;
DE   Flags: Precursor;
GN   Name=STC2;
OS   Macaca nemestrina (Pig-tailed macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9545;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pancreatic islet;
RX   PubMed=10450831; DOI=10.1055/s-2007-978764;
RA   Moore E.E., Kuestner R.E., Conklin D.C., Whitmore T.E., Downey W.,
RA   Buddle M.M., Adams R.L., Bell L.A., Thompson D.L., Wolf A., Chen L.,
RA   Stamm M.R., Grant F.J., Lok S., Ren H., de Jongh K.S.;
RT   "Stanniocalcin 2: characterization of the protein and its localization to
RT   human pancreatic alpha cells.";
RL   Horm. Metab. Res. 31:406-414(1999).
CC   -!- FUNCTION: Has an anti-hypocalcemic action on calcium and phosphate
CC       homeostasis.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the stanniocalcin family. {ECO:0000305}.
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DR   EMBL; AF035377; AAD02027.1; -; mRNA.
DR   RefSeq; NP_001292852.1; NM_001305923.1.
DR   AlphaFoldDB; O97561; -.
DR   STRING; 9545.ENSMNEP00000016124; -.
DR   Ensembl; ENSMNET00000040338; ENSMNEP00000016124; ENSMNEG00000032109.
DR   GeneID; 105480892; -.
DR   CTD; 8614; -.
DR   GeneTree; ENSGT00390000005989; -.
DR   OMA; SNEWEDE; -.
DR   OrthoDB; 1195745at2759; -.
DR   Proteomes; UP000233120; Unplaced.
DR   Bgee; ENSMNEG00000032109; Expressed in spleen and 5 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR   GO; GO:0020037; F:heme binding; IEA:Ensembl.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0046885; P:regulation of hormone biosynthetic process; IEA:Ensembl.
DR   InterPro; IPR004978; Stanniocalcin.
DR   PANTHER; PTHR11245; PTHR11245; 1.
DR   Pfam; PF03298; Stanniocalcin; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Phosphoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..302
FT                   /note="Stanniocalcin-2"
FT                   /id="PRO_0000033304"
FT   REGION          23..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          218..302
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        229..268
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         250
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O76061"
FT   MOD_RES         251
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O76061"
FT   MOD_RES         254
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:O76061"
FT   CARBOHYD        73
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   302 AA;  33282 MW;  62953CE958AF64C1 CRC64;
     MCAERLGHFM TLALVLATID PARGTDATNP PEGPQDRSSQ QKGRLSLQNT AEIQHCLVNA
     GDVGCGVFEC FENNSCEIRG LHGICMTFLH NAGKFDAQGK SFIKDALKCK AHALRHRFGC
     ISRKCPAIRE MVFQLQRECY LKHDLCAAAQ ENTRVIVEMI HFKDLLLHEP YVDLVNLLLT
     CGEEVKEAIT HSVQVQCEQN WGSLCSILSF CTSAIQRPPT APPERQPQVD RAKLSRAHHG
     EAGHHLPEPS SRETGRGAKG ERGSKSHPNA HARGRVGGLG AQGPSGSSEW EDEQSEYSDI
     RR