ID   STC2_PONAB              Reviewed;         302 AA.
AC   Q5RAT2;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Stanniocalcin-2;
DE            Short=STC-2;
DE   Flags: Precursor;
GN   Name=STC2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has an anti-hypocalcemic action on calcium and phosphate
CC       homeostasis. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the stanniocalcin family. {ECO:0000305}.
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DR   EMBL; CR858930; CAH91128.1; -; mRNA.
DR   RefSeq; NP_001125660.1; NM_001132188.1.
DR   AlphaFoldDB; Q5RAT2; -.
DR   STRING; 9601.ENSPPYP00000017968; -.
DR   GeneID; 100172580; -.
DR   KEGG; pon:100172580; -.
DR   CTD; 8614; -.
DR   eggNOG; ENOG502QU7E; Eukaryota.
DR   InParanoid; Q5RAT2; -.
DR   OrthoDB; 1195745at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004978; Stanniocalcin.
DR   PANTHER; PTHR11245; PTHR11245; 1.
DR   Pfam; PF03298; Stanniocalcin; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Phosphoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..302
FT                   /note="Stanniocalcin-2"
FT                   /id="PRO_0000033306"
FT   REGION          23..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          217..302
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        229..268
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         250
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O76061"
FT   MOD_RES         251
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O76061"
FT   MOD_RES         254
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:O76061"
FT   CARBOHYD        73
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        74
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   302 AA;  33331 MW;  F1F22156A85DAFCA CRC64;
     MCAERLGQFM TLALVLATFD PARGTDATNP PEGPQDRSPQ QKGRLSLQNT AEIQHCLVNA
     GDVGCGVFEC FENNSSEIRG LHGICMTFLH NAGKFDAQGK SFIKDALKCK AHALRHRFGC
     ISRKCPAIRE MVFQLQRECY LKHDLCAAAQ ENTRVIVEMI HFKDLLLHEP YVDLVNLLLT
     CGEEVKEAIT HSVQVQCEQN WGSLCSILSF CTSAIQRPPT APPERQPQVD RTKLSRAHHG
     EAGHHLPEPS SRETGRGAKG ERGSKSHPNA HARGRVGGLG AQGPSGSSEW EDEQSEYSDI
     RR