ID   STC2_RAT                Reviewed;         296 AA.
AC   Q9R0K8;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Stanniocalcin-2;
DE            Short=STC-2;
DE   Flags: Precursor;
GN   Name=Stc2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=10508929; DOI=10.1016/s0014-5793(99)01225-9;
RA   Honda S., Kashiwagi M., Ookata K., Tojo A., Hirose S.;
RT   "Regulation by 1alpha,25-dihydroxyvitamin D(3) of expression of
RT   stanniocalcin messages in the rat kidney and ovary.";
RL   FEBS Lett. 459:119-122(1999).
CC   -!- FUNCTION: Has an anti-hypocalcemic action on calcium and phosphate
CC       homeostasis.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in a variety of tissues. Strongly
CC       expressed in ovary and to a lesser extent in kidney.
CC   -!- SIMILARITY: Belongs to the stanniocalcin family. {ECO:0000305}.
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DR   EMBL; AB030707; BAA85251.1; -; mRNA.
DR   RefSeq; NP_071566.1; NM_022230.2.
DR   AlphaFoldDB; Q9R0K8; -.
DR   STRING; 10116.ENSRNOP00000028146; -.
DR   GlyGen; Q9R0K8; 1 site.
DR   PaxDb; Q9R0K8; -.
DR   Ensembl; ENSRNOT00000028146; ENSRNOP00000028146; ENSRNOG00000020729.
DR   GeneID; 63878; -.
DR   KEGG; rno:63878; -.
DR   UCSC; RGD:621777; rat.
DR   CTD; 8614; -.
DR   RGD; 621777; Stc2.
DR   eggNOG; ENOG502QU7E; Eukaryota.
DR   GeneTree; ENSGT00390000005989; -.
DR   HOGENOM; CLU_064102_0_0_1; -.
DR   InParanoid; Q9R0K8; -.
DR   OMA; SNEWEDE; -.
DR   OrthoDB; 1195745at2759; -.
DR   PhylomeDB; Q9R0K8; -.
DR   TreeFam; TF324693; -.
DR   Reactome; R-RNO-381426; Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
DR   Reactome; R-RNO-8957275; Post-translational protein phosphorylation.
DR   PRO; PR:Q9R0K8; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000020729; Expressed in spleen and 17 other tissues.
DR   Genevisible; Q9R0K8; RN.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISO:RGD.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD.
DR   GO; GO:0019899; F:enzyme binding; ISO:RGD.
DR   GO; GO:0020037; F:heme binding; ISO:RGD.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0042803; F:protein homodimerization activity; ISO:RGD.
DR   GO; GO:0055074; P:calcium ion homeostasis; ISO:RGD.
DR   GO; GO:0006874; P:cellular calcium ion homeostasis; IMP:MGI.
DR   GO; GO:0071456; P:cellular response to hypoxia; IEP:RGD.
DR   GO; GO:0046697; P:decidualization; IEP:RGD.
DR   GO; GO:0007566; P:embryo implantation; IEP:RGD.
DR   GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; ISO:RGD.
DR   GO; GO:0010629; P:negative regulation of gene expression; ISO:RGD.
DR   GO; GO:0040015; P:negative regulation of multicellular organism growth; ISO:RGD.
DR   GO; GO:0046885; P:regulation of hormone biosynthetic process; ISO:RGD.
DR   GO; GO:2001256; P:regulation of store-operated calcium entry; ISO:RGD.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; ISO:RGD.
DR   GO; GO:0006979; P:response to oxidative stress; ISO:RGD.
DR   GO; GO:0043434; P:response to peptide hormone; IEP:RGD.
DR   GO; GO:0033280; P:response to vitamin D; IEP:RGD.
DR   InterPro; IPR004978; Stanniocalcin.
DR   PANTHER; PTHR11245; PTHR11245; 1.
DR   Pfam; PF03298; Stanniocalcin; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..296
FT                   /note="Stanniocalcin-2"
FT                   /id="PRO_0000033307"
FT   REGION          22..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          236..296
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        236..262
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        73
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   296 AA;  32622 MW;  0903639858D9B2DC CRC64;
     MCAERLGQFV TLALVFATLD PARGTDSTNP PEGPQDRGSQ QKGRLSLQNT AEIQHCLVNA
     GDVGCGVFEC FENNSCEIQG LHGICMTFLH NAGKFDAQGK SFIKDALRCK AHALRHKFGC
     ISRKCPAIRE MVYQLQRECY LKHDLCSAAQ ENVVVIVEMI HFKDLLLHEP YVDLVNLLLT
     CGEDVREAVT RSVQAQCEQS WGGLCSILSF CTSNIQRPPT AAPEHQPLAD RAQLSRPYHR
     DTDHHLTANR GAKGERGSKS HLHAHARGGA GGQSAQGPSG SSEWEDEQSE YSDIRR