STC2_STAAU
ID STC2_STAAU Reviewed; 715 AA.
AC P17855;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Staphylocoagulase;
DE Flags: Precursor;
OS Staphylococcus aureus.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=1280;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PARTIAL PROTEIN SEQUENCE.
RC STRAIN=BB;
RX PubMed=3481366; DOI=10.1093/oxfordjournals.jbchem.a122156;
RA Kaida S., Miyata T., Yoshizawa Y., Kawabata S., Morita T., Igarashi H.,
RA Iwanaga S.;
RT "Nucleotide sequence of the staphylocoagulase gene: its unique COOH-
RT terminal 8 tandem repeats.";
RL J. Biochem. 102:1177-1186(1987).
CC -!- FUNCTION: Staphylocoagulase is an extracellular protein which
CC specifically forms a complex with human prothrombin. This complex named
CC staphylothrombin can clot fibrinogen without any proteolytic cleavage
CC of prothrombin.
CC -!- DOMAIN: The C-terminal tandem repeats are not required for the
CC procoagulant activity.
CC -!- SIMILARITY: Belongs to the staphylocoagulase family. {ECO:0000305}.
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DR EMBL; D00184; BAA00126.1; -; Genomic_DNA.
DR PIR; A41511; A41511.
DR PDB; 2A1D; X-ray; 3.50 A; D/H=27-355.
DR PDBsum; 2A1D; -.
DR AlphaFoldDB; P17855; -.
DR SMR; P17855; -.
DR EvolutionaryTrace; P17855; -.
DR GO; GO:0016504; F:peptidase activator activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.120.750; -; 1.
DR Gene3D; 1.20.120.760; -; 1.
DR InterPro; IPR043072; Staphylcoagulase_N_1.
DR InterPro; IPR043071; Staphylcoagulase_N_2.
DR InterPro; IPR001443; Staphylcoagulase_rpt.
DR InterPro; IPR014874; Staphylocoagulase_N.
DR Pfam; PF08764; Coagulase; 1.
DR Pfam; PF04022; Staphylcoagulse; 8.
DR PROSITE; PS00429; STAPHYLOCOAGULASE; 8.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Prothrombin activator; Repeat;
KW Signal.
FT SIGNAL 1..26
FT CHAIN 27..715
FT /note="Staphylocoagulase"
FT /id="PRO_0000022425"
FT REPEAT 495..521
FT /note="1"
FT REPEAT 522..548
FT /note="2"
FT REPEAT 549..575
FT /note="3"
FT REPEAT 576..602
FT /note="4"
FT REPEAT 603..629
FT /note="5"
FT REPEAT 630..656
FT /note="6"
FT REPEAT 657..683
FT /note="7"
FT REPEAT 684..710
FT /note="8"
FT REGION 306..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 495..710
FT /note="8 X 27 AA tandem repeats of A-R-P-[RT]-[FQY]-[NK]-K-
FT [PA]-S-[EK]-T-N-A-Y-N-V-T-T-[NH]-[QAG]-[DN]-G-[TQ]-[VA]-
FT [ST]-Y-G"
FT REGION 674..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..331
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT TURN 41..44
FT /evidence="ECO:0007829|PDB:2A1D"
FT HELIX 50..72
FT /evidence="ECO:0007829|PDB:2A1D"
FT HELIX 74..76
FT /evidence="ECO:0007829|PDB:2A1D"
FT TURN 79..81
FT /evidence="ECO:0007829|PDB:2A1D"
FT HELIX 82..118
FT /evidence="ECO:0007829|PDB:2A1D"
FT TURN 132..134
FT /evidence="ECO:0007829|PDB:2A1D"
FT HELIX 142..168
FT /evidence="ECO:0007829|PDB:2A1D"
FT HELIX 171..173
FT /evidence="ECO:0007829|PDB:2A1D"
FT HELIX 178..203
FT /evidence="ECO:0007829|PDB:2A1D"
FT TURN 206..208
FT /evidence="ECO:0007829|PDB:2A1D"
FT HELIX 209..223
FT /evidence="ECO:0007829|PDB:2A1D"
FT STRAND 226..228
FT /evidence="ECO:0007829|PDB:2A1D"
FT HELIX 235..256
FT /evidence="ECO:0007829|PDB:2A1D"
FT TURN 269..271
FT /evidence="ECO:0007829|PDB:2A1D"
FT TURN 274..276
FT /evidence="ECO:0007829|PDB:2A1D"
FT HELIX 278..294
FT /evidence="ECO:0007829|PDB:2A1D"
FT HELIX 299..301
FT /evidence="ECO:0007829|PDB:2A1D"
SQ SEQUENCE 715 AA; 80100 MW; 46ABC9567AF5F128 CRC64;
MKKQIISLGA LAVASSLFTW DNKADAIVTK DYSKESRVNE NSKYGTLISD WYLKGRLTSL
ESQFINALDI LETYHYGEKE YKDAKDKLMT RILGEDQYLL ERKKVQYEEY KKLYQKYKEE
NPTSKGLKLK TFDQYTIEDL TMREYNELTE SLKSAVKDFE KDVEKIENQH HDLKPFTDEM
EEKATSRVDD LANKAYSVYF AFVRDTQHKT EALELKAKVD LVLGDEDKPH RISNERIEKE
MIKDLESIIE DFFIETGLNK PGNITSYDSS KHHYKNHSEG FEALVKETRE AVANADESWK
TKTVKKYGES ETKSPVVKEE NKVEDPQSPK FDNQQEVKTT AGKAEETTQP VAQPLVKIPQ
GTITGEIVKG PEYPTMENKT LQGEIVQGPD FPTMEQSGPS LSDNYTQPTT PNPILEGLEG
SSSKLEIKPQ GTESTLKGIQ GESSDIEVKP QATETTEASQ YGPRPQFNKT PKYVKYRDAG
TGIREYNDGT FGYEARPRFN KPSETNAYNV TTNQDGTVSY GARPTQNKAS ETNAYNVTTH
ANGQVSYGAR PTQKKPSETN AYNVTTHANG QVSYGARPTY NKPSETNAYN VTTHGNGQVS
YGARPTYKKP SKTNAYNVTT HANGQVSYGA RPTQNKPSET NAYNVTTHAN GQVSYGARPT
QNKPSETNAY NVTTHGNGQV SYGARPTYNK PSKTNAYNVT THADGTATYG PRVTK
