ID   STC_CLOBE               Reviewed;         632 AA.
AC   P26047; Q9L9X1;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 3.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Signal-transduction and transcriptional-control protein;
GN   Name=stc;
OS   Clostridium beijerinckii (Clostridium MP).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1520;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NRRL B-593;
RA   Rifaat M.M., Chen J.S.;
RT   "The predicted protein product of a putative regulatory gene from
RT   Clostridium beijerinckii NRRL B593 is homologous to the NtrC subfamily of
RT   transcriptional regulators.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AF157307; AAD54950.2; -; Genomic_DNA.
DR   AlphaFoldDB; P26047; -.
DR   SMR; P26047; -.
DR   PRIDE; P26047; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR002197; HTH_Fis.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR002078; Sigma_54_int.
DR   InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR   InterPro; IPR025943; Sigma_54_int_dom_ATP-bd_2.
DR   InterPro; IPR025944; Sigma_54_int_dom_CS.
DR   Pfam; PF02954; HTH_8; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   Pfam; PF00158; Sigma54_activat; 1.
DR   PRINTS; PR01590; HTHFIS.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00091; PAS; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS50112; PAS; 1.
DR   PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR   PROSITE; PS00676; SIGMA54_INTERACT_2; 1.
DR   PROSITE; PS00688; SIGMA54_INTERACT_3; 1.
DR   PROSITE; PS50045; SIGMA54_INTERACT_4; 1.
PE   4: Predicted;
KW   ATP-binding; DNA-binding; Nucleotide-binding; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..632
FT                   /note="Signal-transduction and transcriptional-control
FT                   protein"
FT                   /id="PRO_0000081336"
FT   DOMAIN          197..270
FT                   /note="PAS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT   DOMAIN          324..554
FT                   /note="Sigma-54 factor interaction"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT   DNA_BIND        606..625
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
FT   BINDING         352..359
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
FT   BINDING         416..425
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00193"
SQ   SEQUENCE   632 AA;  71507 MW;  734BDC743939FB89 CRC64;
     MLRRYTYNEI IKKSHKRCSN YGIKIDIPCP SKILRDEEFN VIIQKNKALI EIARPFMEIL
     YNFLKGSGFS LYFTEKNGVV LTIIGDQDII RDQIQMGIIE GADMSEKSAG TNGIGTAFAE
     NISLQISGEE HFIKVFQIWT CSSSVVHDED GNIIGCLNLT GRRQLAHPHT LGLVVAAVKS
     IENHLKVKKT QNELVKTYQY LNKITDSVNL GIFAVDTKGI IKAINKSACD MLHINEEDVI
     NKNVDTVLDS WKHILQRLRN GQSYEDEEIM YSDKKKRFNI NVYPIKDKNS NITGMVGIFK
     DIQNVYNLVN KYINRTAKYT FDDIIGQSEA MKRLKEQIKS ISNSPSTVLI QGESGTGKEL
     IAQSIHNNSN RRSKSFVAIN CGAIPKSLIE SELFGYEEGA FTGAKRGGCP GKFELANEGT
     LFLDEIGEMP LDMQVNLLRV LQEGCITRIG GNKCVDVDVR IIAATNKNLK KEIEDGNFRE
     DLYYRLSVIP IYVPPLRERN GDIGILIEHF LKIKADKLGK LIPEIRKNIY ENLLSYGWPG
     NVRELENCIE NIVNMNGNTS FNFENRTIKK DVNCYSDVSL EYDMCSLEEL EKRAISICIN
     QCGGNISKAC RILGINRSTL YIKIKKYNIK VR