ID   STC_ONCKE               Reviewed;         179 AA.
AC   P43647; Q91427;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Stanniocalcin;
DE            Short=STC;
DE   AltName: Full=Corpuscles of Stannius protein;
DE            Short=CS;
DE   AltName: Full=Hypocalcin;
DE   AltName: Full=Teleocalcin;
GN   Name=stc;
OS   Oncorhynchus keta (Chum salmon) (Salmo keta).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8018;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE.
RC   TISSUE=Stannius corpuscle;
RX   PubMed=7489819; DOI=10.1016/0303-7207(95)03590-4;
RA   Yamashita K., Koide Y., Itoh H., Kawada N., Kawauchi H.;
RT   "The complete amino acid sequence of chum salmon stanniocalcin, a calcium-
RT   regulating hormone in teleosts.";
RL   Mol. Cell. Endocrinol. 112:159-167(1995).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-33.
RC   TISSUE=Stannius corpuscle;
RX   PubMed=1430418; DOI=10.1007/bf00264807;
RA   Sundell K., Bjoernsson B.T., Itoh H., Kawauchi H.;
RT   "Chum salmon (Oncorhynchus keta) stanniocalcin inhibits in vitro intestinal
RT   calcium uptake in Atlantic cod (Gadus morhua).";
RL   J. Comp. Physiol. B 162:489-495(1992).
RN   [3]
RP   DISULFIDE BONDS.
RX   PubMed=10198206; DOI=10.1006/bbrc.1999.0466;
RA   Hulova I., Kawauchi H.;
RT   "Assignment of disulfide linkages in chum salmon stanniocalcin.";
RL   Biochem. Biophys. Res. Commun. 257:295-299(1999).
CC   -!- FUNCTION: Its primary function is the prevention of hypercalcemia. Upon
CC       release into the circulation, it lowers calcium transport by the gills,
CC       thereby reducing its rate of influx from the environment into the
CC       extracellular compartment. STC also stimulates phosphate reabsorption
CC       by renal proximal tubules. The consequence of this action is increased
CC       levels of plasma phosphate, which combines with excess calcium and
CC       promotes its disposal into bone and scales.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000269|PubMed:10198206}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Produced and secreted by the corpuscles of
CC       Stannius.
CC   -!- SIMILARITY: Belongs to the stanniocalcin family. {ECO:0000305}.
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DR   EMBL; S80134; AAB35648.2; -; mRNA.
DR   AlphaFoldDB; P43647; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006816; P:calcium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR004978; Stanniocalcin.
DR   PANTHER; PTHR11245; PTHR11245; 1.
DR   Pfam; PF03298; Stanniocalcin; 1.
PE   1: Evidence at protein level;
KW   Calcium; Calcium transport; Direct protein sequencing; Disulfide bond;
KW   Glycoprotein; Hormone; Ion transport; Secreted; Transport.
FT   CHAIN           1..179
FT                   /note="Stanniocalcin"
FT                   /id="PRO_0000182020"
FT   CARBOHYD        29
FT                   /note="N-linked (GlcNAc...) asparagine"
FT   DISULFID        12..26
FT                   /evidence="ECO:0000269|PubMed:10198206"
FT   DISULFID        21..41
FT                   /evidence="ECO:0000269|PubMed:10198206"
FT   DISULFID        32..81
FT                   /evidence="ECO:0000269|PubMed:10198206"
FT   DISULFID        65..95
FT                   /evidence="ECO:0000269|PubMed:10198206"
FT   DISULFID        102..137
FT                   /evidence="ECO:0000269|PubMed:10198206"
FT   DISULFID        169
FT                   /note="Interchain"
FT                   /evidence="ECO:0000269|PubMed:10198206"
FT   CONFLICT        160
FT                   /note="P -> L (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        170
FT                   /note="S -> P (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   179 AA;  19518 MW;  0298CAC33E2BE445 CRC64;
     FSPNSPSDVA RCLNGALDVG CGTFACLENS TCDTDGMHDI CQLFFHTAAT FNTQGKTFVK
     ESLRCIANGV TSKVFQTIRR CGVFQRMISE VQEECYSRLD ICGVARSNPE AIGEVVQVPA
     HFPNRYYSTL LQSLLACDEE TVAVVRAGLV ARLGPDMETP FQLLQNKHCS QGSNQGPNS