ID   STC_ONCKI               Reviewed;         256 AA.
AC   Q08264;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Stanniocalcin;
DE            Short=STC;
DE   AltName: Full=Corpuscles of Stannius protein;
DE            Short=CS;
DE   AltName: Full=Hypocalcin;
DE   AltName: Full=Teleocalcin;
DE   Flags: Precursor;
GN   Name=stc;
OS   Oncorhynchus kisutch (Coho salmon) (Salmo kisutch).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8019;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1363790; DOI=10.1016/0303-7207(92)90095-n;
RA   Wagner G.F., Dimattia G.E., Davie J.R., Copp D.H., Friesen H.G.;
RT   "Molecular cloning and cDNA sequence analysis of coho salmon
RT   stanniocalcin.";
RL   Mol. Cell. Endocrinol. 90:7-15(1992).
RN   [2]
RP   PROTEIN SEQUENCE OF 34-73.
RX   PubMed=3197944; DOI=10.1016/0016-6480(88)90206-7;
RA   Wagner G.F., Fenwick J.C., Park C.M., Milliken C., Copp D.H., Friesen H.G.;
RT   "Comparative biochemistry and physiology of teleocalcin from sockeye and
RT   coho salmon.";
RL   Gen. Comp. Endocrinol. 72:237-246(1988).
CC   -!- FUNCTION: Its primary function is the prevention of hypercalcemia. Upon
CC       release into the circulation, it lowers calcium transport by the gills,
CC       thereby reducing its rate of influx from the environment into the
CC       extracellular compartment. STC also stimulates phosphate reabsorption
CC       by renal proximal tubules. The consequence of this action is increased
CC       levels of plasma phosphate, which combines with excess calcium and
CC       promotes its disposal into bone and scales.
CC   -!- SUBUNIT: Homodimer; disulfide-linked.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Produced and secreted by the corpuscles of
CC       Stannius.
CC   -!- SIMILARITY: Belongs to the stanniocalcin family. {ECO:0000305}.
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DR   EMBL; S59519; AAB26419.1; -; mRNA.
DR   PIR; B60841; B60841.
DR   PIR; I51197; I51197.
DR   AlphaFoldDB; Q08264; -.
DR   OrthoDB; 1019934at2759; -.
DR   Proteomes; UP000694557; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006816; P:calcium ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0051926; P:negative regulation of calcium ion transport; IDA:UniProtKB.
DR   InterPro; IPR004978; Stanniocalcin.
DR   PANTHER; PTHR11245; PTHR11245; 1.
DR   Pfam; PF03298; Stanniocalcin; 1.
PE   1: Evidence at protein level;
KW   Calcium; Calcium transport; Direct protein sequencing; Disulfide bond;
KW   Glycoprotein; Hormone; Ion transport; Reference proteome; Secreted; Signal;
KW   Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..33
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000033310"
FT   CHAIN           34..256
FT                   /note="Stanniocalcin"
FT                   /id="PRO_0000033311"
FT   CARBOHYD        62
FT                   /note="N-linked (GlcNAc...) asparagine"
SQ   SEQUENCE   256 AA;  28074 MW;  E688B930B394A8D3 CRC64;
     MLAKFGLCAV FLVLGTAATF DTDPEEASPR RARFSSNSPS DVARCLNGAL AVGCGTFACL
     ENSTCDTDGM HDICQLFFHT AATFNTQGKT FVKESLRCIA NGVTSKVFQT IRRCGVFQRM
     ISEVQEECYS RLDICGVARS NPEAIGEVVQ VPAHFPNRYY STLLQSLLAC DEETVAVVRA
     GLVARLGPDM ETLFQLLQNK HCPQGSNQGP NSAPAGWRWP MGSPPSFKIQ PSMRGRDPTH
     LFARKRSVEA LERVME