ID   STC_ONCMY               Reviewed;         256 AA.
AC   P43648; Q98SE1;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   11-FEB-2002, sequence version 2.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Stanniocalcin;
DE            Short=STC;
DE   AltName: Full=Corpuscles of Stannius protein;
DE            Short=CS;
DE   AltName: Full=Hypocalcin;
DE   AltName: Full=Teleocalcin;
DE   Flags: Precursor;
GN   Name=stc;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RA   McCudden C.R., Wagner G.F.;
RT   "Rainbow trout ovarian stanniocalcin.";
RL   Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE OF 34-66.
RC   TISSUE=Stannius corpuscle;
RX   PubMed=3360288; DOI=10.1016/0016-6480(88)90048-2;
RA   Lafeber F.P.J.G., Hanssen R.G.J.M., Choy Y.M., Flik G.,
RA   Herrmann-Erlee M.P.M., Pang P.K.T., Wendelaar Bonga S.E.;
RT   "Identification of hypocalcin (teleocalcin) isolated from trout Stannius
RT   corpuscles.";
RL   Gen. Comp. Endocrinol. 69:19-30(1988).
CC   -!- FUNCTION: Its primary function is the prevention of hypercalcemia. Upon
CC       release into the circulation, it lowers calcium transport by the gills,
CC       thereby reducing its rate of influx from the environment into the
CC       extracellular compartment. STC also stimulates phosphate reabsorption
CC       by renal proximal tubules. The consequence of this action is increased
CC       levels of plasma phosphate, which combines with excess calcium and
CC       promotes its disposal into bone and scales.
CC   -!- SUBUNIT: Homodimer; disulfide-linked.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Produced and secreted by the corpuscles of
CC       Stannius.
CC   -!- SIMILARITY: Belongs to the stanniocalcin family. {ECO:0000305}.
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DR   EMBL; AF326317; AAK01423.1; -; mRNA.
DR   EMBL; AF326318; AAK01424.1; -; mRNA.
DR   PIR; S06337; S06337.
DR   RefSeq; NP_001117762.1; NM_001124290.1.
DR   AlphaFoldDB; P43648; -.
DR   Ensembl; ENSOMYT00000000409; ENSOMYP00000000323; ENSOMYG00000000255.
DR   GeneID; 100135946; -.
DR   KEGG; omy:100135946; -.
DR   GeneTree; ENSGT00390000005989; -.
DR   OrthoDB; 1019934at2759; -.
DR   GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR   GO; GO:0005771; C:multivesicular body; IDA:AgBase.
DR   GO; GO:0005634; C:nucleus; IDA:AgBase.
DR   GO; GO:0060418; C:yolk plasma; IDA:AgBase.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0055074; P:calcium ion homeostasis; NAS:AgBase.
DR   GO; GO:0006816; P:calcium ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0051592; P:response to calcium ion; IDA:AgBase.
DR   GO; GO:0010035; P:response to inorganic substance; IDA:AgBase.
DR   GO; GO:0043434; P:response to peptide hormone; IDA:AgBase.
DR   InterPro; IPR004978; Stanniocalcin.
DR   PANTHER; PTHR11245; PTHR11245; 1.
DR   Pfam; PF03298; Stanniocalcin; 1.
PE   1: Evidence at protein level;
KW   Calcium; Calcium transport; Direct protein sequencing; Disulfide bond;
KW   Glycoprotein; Hormone; Ion transport; Secreted; Signal; Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..33
FT                   /evidence="ECO:0000269|PubMed:3360288"
FT                   /id="PRO_0000033312"
FT   CHAIN           34..256
FT                   /note="Stanniocalcin"
FT                   /id="PRO_0000033313"
FT   REGION          204..241
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        62
FT                   /note="N-linked (GlcNAc...) asparagine"
FT   VARIANT         41
FT                   /note="D -> E"
SQ   SEQUENCE   256 AA;  28104 MW;  E688A0E0B394A8D3 CRC64;
     MLAKFGLCAV FLVLGTAATF DTDPEEASPR RARFSSNSPS DVARCLNGAL AVGCGTFACL
     ENSTCDTDGM HDICQLFFHT AATFNTQGKT FVKESLRCIA NGVTSKVFQT IRRCGVFQRM
     ISEVQEECYS RLDICGVARS NPEAIGEVVQ VPAHFPNRYY STLLQSLLAC DEETVAVVRA
     GLVARLGPDM ETLFQLLQNK HCPQGSNQGP NSAPAGWRWP MGSPPSFKIQ PSMRGRDPTH
     LFARKRSVEA LEREME