ID   STC_ONCNE               Reviewed;          40 AA.
AC   P43649;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Stanniocalcin;
DE            Short=STC;
DE   AltName: Full=Corpuscles of Stannius protein;
DE            Short=CS;
DE   AltName: Full=Hypocalcin;
DE   AltName: Full=Teleocalcin;
DE   Flags: Fragment;
GN   Name=stc;
OS   Oncorhynchus nerka (Sockeye salmon) (Salmo nerka).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8023;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=3197944; DOI=10.1016/0016-6480(88)90206-7;
RA   Wagner G.F., Fenwick J.C., Park C.M., Milliken C., Copp D.H., Friesen H.G.;
RT   "Comparative biochemistry and physiology of teleocalcin from sockeye and
RT   coho salmon.";
RL   Gen. Comp. Endocrinol. 72:237-246(1988).
CC   -!- FUNCTION: Its primary function is the prevention of hypercalcemia. Upon
CC       release into the circulation, it lowers calcium transport by the gills,
CC       thereby reducing its rate of influx from the environment into the
CC       extracellular compartment. STC also stimulates phosphate reabsorption
CC       by renal proximal tubules. The consequence of this action is increased
CC       levels of plasma phosphate, which combines with excess calcium and
CC       promotes its disposal into bone and scales.
CC   -!- SUBUNIT: Homodimer; disulfide-linked.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Produced and secreted by the corpuscles of
CC       Stannius.
CC   -!- SIMILARITY: Belongs to the stanniocalcin family. {ECO:0000305}.
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DR   PIR; A60841; A60841.
DR   AlphaFoldDB; P43649; -.
DR   GO; GO:0005615; C:extracellular space; IDA:AgBase.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0006816; P:calcium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR004978; Stanniocalcin.
DR   PANTHER; PTHR11245; PTHR11245; 1.
DR   Pfam; PF03298; Stanniocalcin; 1.
PE   1: Evidence at protein level;
KW   Calcium; Calcium transport; Direct protein sequencing; Disulfide bond;
KW   Glycoprotein; Hormone; Ion transport; Secreted; Transport.
FT   CHAIN           1..>40
FT                   /note="Stanniocalcin"
FT                   /id="PRO_0000182021"
FT   CARBOHYD        29
FT                   /note="N-linked (GlcNAc...) asparagine"
FT   UNSURE          29
FT   NON_TER         40
SQ   SEQUENCE   40 AA;  4135 MW;  0C517B7BBBC5EE6C CRC64;
     FSPNSPSDVA RCLNGALDVG CGTFACLENS TCDTDGMHDI