ID   STDH1_CAEEL             Reviewed;         314 AA.
AC   Q17703;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Putative steroid dehydrogenase 1;
DE            EC=1.1.1.-;
GN   Name=stdh-1; ORFNames=C06B3.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. 17-beta-HSD 3 subfamily. {ECO:0000305}.
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DR   EMBL; Z77652; CAB01114.1; -; Genomic_DNA.
DR   PIR; T18980; T18980.
DR   RefSeq; NP_506449.1; NM_074048.1.
DR   AlphaFoldDB; Q17703; -.
DR   SMR; Q17703; -.
DR   STRING; 6239.C06B3.4; -.
DR   EPD; Q17703; -.
DR   PaxDb; Q17703; -.
DR   PeptideAtlas; Q17703; -.
DR   EnsemblMetazoa; C06B3.4.1; C06B3.4.1; WBGene00007363.
DR   GeneID; 182291; -.
DR   KEGG; cel:CELE_C06B3.4; -.
DR   UCSC; C06B3.4; c. elegans.
DR   CTD; 182291; -.
DR   WormBase; C06B3.4; CE07961; WBGene00007363; stdh-1.
DR   eggNOG; KOG1014; Eukaryota.
DR   GeneTree; ENSGT00940000165708; -.
DR   HOGENOM; CLU_010194_38_3_1; -.
DR   InParanoid; Q17703; -.
DR   OMA; VFLHGRN; -.
DR   OrthoDB; 913128at2759; -.
DR   PhylomeDB; Q17703; -.
DR   PRO; PR:Q17703; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00007363; Expressed in material anatomical entity and 5 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030497; P:fatty acid elongation; IBA:GO_Central.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Lipid biosynthesis; Lipid metabolism; NADP; Oxidoreductase;
KW   Reference proteome; Steroid biosynthesis.
FT   CHAIN           1..314
FT                   /note="Putative steroid dehydrogenase 1"
FT                   /id="PRO_0000054579"
FT   ACT_SITE        202
FT                   /evidence="ECO:0000250"
FT   BINDING         47..76
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   314 AA;  34605 MW;  C261F9ED72EAC245 CRC64;
     MDIEWFATGV GAVVVLYILY HFIRITLNIL GPYVFCQPID LKKKAGASWA VVTGATDGIG
     KSYSFELAKR GFNVYIVSRT QSKLEHTKKE ILEVHPDIEV RFATFDFTNP SVSDYEKLLS
     KLNEVSIGIL INNVGMFFDY PEMLHKINGG IDSIANVTII NTLPATLLSA GILPQMVPRK
     AGIIVNIGSV AGLATMAEWS VYSATKKYVE WITGCLQKEY GHQGIIFQAI TPAMVATKMA
     GNPNTSFFTP DSDTFAKSAL NTIGHASQTT GYITHQIECE MLKLLPDFVI DRSIKQTSAQ
     LREALAKNEN KPLM