ID   STDH2_CAEEL             Reviewed;         315 AA.
AC   O17795;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Putative steroid dehydrogenase 2;
DE            EC=1.1.1.-;
GN   Name=stdh-2; ORFNames=F11A5.12;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. 17-beta-HSD 3 subfamily. {ECO:0000305}.
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DR   EMBL; Z92830; CAB07363.1; -; Genomic_DNA.
DR   PIR; T20756; T20756.
DR   RefSeq; NP_507092.1; NM_074691.1.
DR   AlphaFoldDB; O17795; -.
DR   SMR; O17795; -.
DR   STRING; 6239.F11A5.12; -.
DR   PaxDb; O17795; -.
DR   PeptideAtlas; O17795; -.
DR   EnsemblMetazoa; F11A5.12.1; F11A5.12.1; WBGene00008678.
DR   GeneID; 184337; -.
DR   KEGG; cel:CELE_F11A5.12; -.
DR   UCSC; F11A5.12; c. elegans.
DR   CTD; 184337; -.
DR   WormBase; F11A5.12; CE15790; WBGene00008678; stdh-2.
DR   eggNOG; KOG1014; Eukaryota.
DR   GeneTree; ENSGT00940000165708; -.
DR   HOGENOM; CLU_010194_38_0_1; -.
DR   InParanoid; O17795; -.
DR   OMA; IQWFATG; -.
DR   OrthoDB; 913128at2759; -.
DR   PhylomeDB; O17795; -.
DR   PRO; PR:O17795; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00008678; Expressed in larva and 1 other tissue.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030497; P:fatty acid elongation; IBA:GO_Central.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Lipid biosynthesis; Lipid metabolism; NADP; Oxidoreductase;
KW   Reference proteome; Steroid biosynthesis.
FT   CHAIN           1..315
FT                   /note="Putative steroid dehydrogenase 2"
FT                   /id="PRO_0000054581"
FT   ACT_SITE        202
FT                   /evidence="ECO:0000250"
FT   BINDING         47..76
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   315 AA;  34872 MW;  F4C9D3D3BEFA539A CRC64;
     MDIQWFATGV GAAVVLYIFY HFIRIILNIL VPYAFCQPID LKKKAGASWA VVTGATDGIG
     KSYSFELARR GFNVYIVSRT QSKLEQTKKD ILEKQPDIEV RFATYDFTNP SVTDYEKLLS
     KLNEVSVGIL INNVGMFFDY PEMLHKINGG IDSIANVIII NTLPATLLSA GILPQMVSRK
     AGIIVNIGSF AGVVKLAEWS IYSATKKYVE WLTGCLRKEY SHHGIIFQAI TPAMVATKMA
     GNPNTSFFCP DSDTFARSAL NTIGHASETT GYIAHQIQCE ILKLLPDFVI DRSIKKGNAE
     FREKALAKSE NKPLA