ID   STDH3_CAEEL             Reviewed;         315 AA.
AC   Q17704;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 2.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Putative steroid dehydrogenase 3;
DE            EC=1.1.1.-;
GN   Name=stdh-3; ORFNames=C06B3.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. 17-beta-HSD 3 subfamily. {ECO:0000305}.
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DR   EMBL; Z77652; CAB01115.2; -; Genomic_DNA.
DR   PIR; T18981; T18981.
DR   RefSeq; NP_506448.2; NM_074047.3.
DR   AlphaFoldDB; Q17704; -.
DR   SMR; Q17704; -.
DR   STRING; 6239.C06B3.5; -.
DR   PaxDb; Q17704; -.
DR   EnsemblMetazoa; C06B3.5.1; C06B3.5.1; WBGene00007364.
DR   GeneID; 182292; -.
DR   KEGG; cel:CELE_C06B3.5; -.
DR   CTD; 182292; -.
DR   WormBase; C06B3.5; CE43017; WBGene00007364; stdh-3.
DR   eggNOG; KOG1014; Eukaryota.
DR   GeneTree; ENSGT00940000165708; -.
DR   HOGENOM; CLU_010194_38_3_1; -.
DR   InParanoid; Q17704; -.
DR   OMA; FLQHWSS; -.
DR   OrthoDB; 895581at2759; -.
DR   PhylomeDB; Q17704; -.
DR   PRO; PR:Q17704; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030497; P:fatty acid elongation; IBA:GO_Central.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Lipid biosynthesis; Lipid metabolism; NADP; Oxidoreductase;
KW   Reference proteome; Steroid biosynthesis.
FT   CHAIN           1..315
FT                   /note="Putative steroid dehydrogenase 3"
FT                   /id="PRO_0000054580"
FT   ACT_SITE        202
FT                   /evidence="ECO:0000250"
FT   BINDING         47..76
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   315 AA;  34955 MW;  F6506CDAAC1BC584 CRC64;
     MNIEWFAIGV GAIVVLYILY HFIKMIWSIL GLYVFYQPID LKKKAGASWA VITGGTDGIG
     KSFSFELAKR GFNIYIVSRT QSKLEQTKKE IMEKYSNVEV RFATFDFTNP SISDYKKLLS
     QLNEVSIGML INNVGMLFEY PENLHKTVGG IDVVANVTIL NTLPVTLLSA GILPQMVSRK
     TGIIVNIGSV AGAAKMAEWS VYSASKKYVE WLTGCLRKEY EHQGIIIQAI TPALVATKLS
     GHTETSLFCP DSATFAKSAL NTVGHTSQTT GYINHQIQCE MLALFPECFL DSFVKKSSVE
     TREKALAKKE NKHLL