ID   STE12_EMENI             Reviewed;         692 AA.
AC   O74252; C8VN37; Q5BAZ0;
DT   30-AUG-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Transcription factor steA;
GN   Name=steA; Synonyms=ste12; ORFNames=AN2290;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=10792717; DOI=10.1046/j.1365-2958.2000.01874.x;
RA   Vallim M.A., Miller K.Y., Miller B.L.;
RT   "Aspergillus SteA (Sterile12-like) is a homeodomain-C2/H2-Zn+2 finger
RT   transcription factor required for sexual reproduction.";
RL   Mol. Microbiol. 36:290-301(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: Transcription factor involved in sexual reproduction.
CC       Required for cleistothecial development and ascosporogenesis. Not
CC       required for asexual reproduction (conidiation). May act to repress
CC       medA expression. {ECO:0000269|PubMed:10792717}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expression is low in vegetative hyphae and
CC       increases during conidiophore development.
CC   -!- SIMILARITY: Belongs to the STE12 transcription factor family.
CC       {ECO:0000305}.
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DR   EMBL; AF080600; AAC31206.1; -; mRNA.
DR   EMBL; AACD01000038; EAA64401.1; -; Genomic_DNA.
DR   EMBL; BN001307; CBF86542.1; -; Genomic_DNA.
DR   RefSeq; XP_659894.1; XM_654802.1.
DR   AlphaFoldDB; O74252; -.
DR   SMR; O74252; -.
DR   BioGRID; 1955935; 1.
DR   STRING; 162425.CADANIAP00008982; -.
DR   PRIDE; O74252; -.
DR   EnsemblFungi; CBF86542; CBF86542; ANIA_02290.
DR   EnsemblFungi; EAA64401; EAA64401; AN2290.2.
DR   GeneID; 2875161; -.
DR   KEGG; ani:AN2290.2; -.
DR   VEuPathDB; FungiDB:AN2290; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   HOGENOM; CLU_025505_0_0_1; -.
DR   InParanoid; O74252; -.
DR   OMA; YVSCILW; -.
DR   OrthoDB; 444142at2759; -.
DR   Proteomes; UP000000560; Chromosome VII.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:1990526; C:Ste12p-Dig1p-Dig2p complex; IBA:GO_Central.
DR   GO; GO:1990527; C:Tec1p-Ste12p-Dig1p complex; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISA:AspGD.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISA:AspGD.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:UniProtKB.
DR   GO; GO:1900376; P:regulation of secondary metabolite biosynthetic process; IMP:AspGD.
DR   GO; GO:0019953; P:sexual reproduction; IMP:UniProtKB.
DR   GO; GO:0000909; P:sporocarp development involved in sexual reproduction; IMP:AspGD.
DR   InterPro; IPR003120; Ste12.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF02200; STE; 1.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00424; STE; 1.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..692
FT                   /note="Transcription factor steA"
FT                   /id="PRO_0000072268"
FT   DNA_BIND        56..165
FT                   /evidence="ECO:0000250"
FT   ZN_FING         564..588
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         594..616
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          406..507
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          519..540
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          618..665
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        470..507
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   692 AA;  76695 MW;  A0B86A6878437C13 CRC64;
     MYSQHGAPMA PPQKPETFML SNEAQQSLPH DAQVALQQVD NLKYFLLSAP VDWQPDQLIR
     RFLLPTGDYI SCVLWSNLFH ISGTDIVRCL AFRFQAFGRP VKNSKKFEEG IFSDLRNLKA
     GTDATLEEPK SPFLDFLYKN NCIRTQKKQK VFYWYSVPHD RLFLDALERD LKREKMGQEA
     TTVAVSEPAL SFEFDSSQSL YEQLTKAQQA NSSSFAAHAS TTYGQSASPV VRTVDAMPPP
     QMAPQMAPPS IPLLTDESAN SQMYTSIPMP NPIPQNLIKR EADYGAIQYD RNGMPIARIH
     QRHSSMPTFV EYSPAPSFVS SQYEDYSNRG LSFEPVTPPQ HSSHIGPEPA YIANEDTGLY
     TAIPEMSTGS GFNPMMHLPP SNLASAHFPT PARTFHSNVY SVLEGSPTYK QRRRRSSIPP
     GAANPVTTGT HSPAPALSYA AHKPSDLRRS VSSSVAPGDT DDSRHESLHR SVNSTYTATL
     PQKNLMHEMS RNGTPLSSVG EHREQSSIPL TQAEDLPALP ANGTVESGAP NGVGHKSDRY
     ATGPVRRARS ATMMELGPYP QKSHSCPIPS CGRLFKRLEH LKRHVRTHTQ ERPYPCPYCN
     KAFSRSDNLA QHRRIHEAQQ DGQPLVHEDD LENDDNESVS HDEDESPSES VHPAVPGVHG
     MTSMPSSVAL QSTMGSMMGS HMIAPQLLQQ QI