STEAL_HUMAN
ID STEAL_HUMAN Reviewed; 245 AA.
AC Q6NZ63; B5MCI2;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=STEAP family member 1B;
GN Name=STEAP1B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Corpus callosum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6NZ63; Q3SYB3: FOXD4L6; NbExp=3; IntAct=EBI-12952093, EBI-6425864;
CC Q6NZ63; P55061: TMBIM6; NbExp=3; IntAct=EBI-12952093, EBI-1045825;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6NZ63-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6NZ63-2; Sequence=VSP_054116, VSP_054117;
CC -!- SIMILARITY: Belongs to the STEAP family. {ECO:0000305}.
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DR EMBL; AK308991; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC002480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC005061; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC099759; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236948; EAL24268.1; -; Genomic_DNA.
DR EMBL; BC066301; AAH66301.1; -; mRNA.
DR CCDS; CCDS55094.1; -. [Q6NZ63-1]
DR CCDS; CCDS56469.1; -. [Q6NZ63-2]
DR RefSeq; NP_001157932.1; NM_001164460.1. [Q6NZ63-2]
DR RefSeq; NP_997225.1; NM_207342.2. [Q6NZ63-1]
DR AlphaFoldDB; Q6NZ63; -.
DR SMR; Q6NZ63; -.
DR BioGRID; 129147; 8.
DR IntAct; Q6NZ63; 7.
DR iPTMnet; Q6NZ63; -.
DR PhosphoSitePlus; Q6NZ63; -.
DR BioMuta; STEAP1B; -.
DR DMDM; 74737025; -.
DR jPOST; Q6NZ63; -.
DR MassIVE; Q6NZ63; -.
DR MaxQB; Q6NZ63; -.
DR PeptideAtlas; Q6NZ63; -.
DR PRIDE; Q6NZ63; -.
DR ProteomicsDB; 6052; -.
DR ProteomicsDB; 66792; -. [Q6NZ63-1]
DR Antibodypedia; 71811; 9 antibodies from 4 providers.
DR DNASU; 256227; -.
DR Ensembl; ENST00000404369.8; ENSP00000384370.4; ENSG00000105889.16. [Q6NZ63-2]
DR Ensembl; ENST00000406890.6; ENSP00000385239.2; ENSG00000105889.16. [Q6NZ63-1]
DR GeneID; 256227; -.
DR KEGG; hsa:256227; -.
DR UCSC; uc003svh.4; human. [Q6NZ63-1]
DR CTD; 256227; -.
DR DisGeNET; 256227; -.
DR GeneCards; STEAP1B; -.
DR HGNC; HGNC:41907; STEAP1B.
DR HPA; ENSG00000105889; Tissue enhanced (brain, choroid plexus).
DR neXtProt; NX_Q6NZ63; -.
DR OpenTargets; ENSG00000105889; -.
DR VEuPathDB; HostDB:ENSG00000105889; -.
DR eggNOG; ENOG502QWI9; Eukaryota.
DR GeneTree; ENSGT00390000008042; -.
DR OrthoDB; 638341at2759; -.
DR PhylomeDB; Q6NZ63; -.
DR TreeFam; TF332031; -.
DR PathwayCommons; Q6NZ63; -.
DR SignaLink; Q6NZ63; -.
DR BioGRID-ORCS; 256227; 10 hits in 1068 CRISPR screens.
DR ChiTaRS; STEAP1B; human.
DR GenomeRNAi; 256227; -.
DR Pharos; Q6NZ63; Tdark.
DR PRO; PR:Q6NZ63; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q6NZ63; protein.
DR Bgee; ENSG00000105889; Expressed in sural nerve and 107 other tissues.
DR ExpressionAtlas; Q6NZ63; baseline and differential.
DR Genevisible; Q6NZ63; HS.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR InterPro; IPR013130; Fe3_Rdtase_TM_dom.
DR Pfam; PF01794; Ferric_reduct; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..245
FT /note="STEAP family member 1B"
FT /id="PRO_0000321512"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 28
FT /note="L -> LHEDTGETSMLKRPVLLHLQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054116"
FT VAR_SEQ 235..245
FT /note="QVHGRINFLTL -> QAILTGSLVALCNFQATKLAKTQLVGTPNFWQEQQCG
FT IHFPPPSKTRSYIYFILSAASPSKGNVSSHMFQLHLENLNKKDKLLLIIFQI (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054117"
FT VARIANT 7
FT /note="I -> V (in dbSNP:rs7787814)"
FT /id="VAR_039339"
FT VARIANT 29
FT /note="Q -> R (in dbSNP:rs16881810)"
FT /id="VAR_039340"
FT VARIANT 166
FT /note="R -> M (in dbSNP:rs16881812)"
FT /id="VAR_039341"
FT VARIANT 210
FT /note="I -> T (in dbSNP:rs16881817)"
FT /id="VAR_039342"
SQ SEQUENCE 245 AA; 28815 MW; A9D38F66C3580B7C CRC64;
MESRKDITNQ EEIWKMKPRR NLEDNDYLQT AHADEFDCPS ELQHAQELFP QWHLPIKIAA
VMASLTFLYT LLREVIHPLA TSHQQYFYKI PILVINKVLP MVSITLLALV YLPGVIAAIV
QVHNGTKYKK FPHWLDKWML TRKQFGLLSL FFAVLHAIYT LSYAMRRSYR YKLLNWAYQQ
VQQNKEDAWI EHDVWRMEIY VSLGIVGLAI LALLAVTSIP SVSDSLTWRE FHYIQVHGRI
NFLTL
