ID   STEA_SALT1              Reviewed;         210 AA.
AC   D0ZXR5;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2010, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Secreted effector protein SteA;
DE   AltName: Full=Salmonella translocated effector A;
GN   Name=steA; OrderedLocusNames=STM14_1912;
OS   Salmonella typhimurium (strain 14028s / SGSC 2262).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=588858;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=14028s / SGSC 2262;
RX   PubMed=19897643; DOI=10.1128/jb.01233-09;
RA   Jarvik T., Smillie C., Groisman E.A., Ochman H.;
RT   "Short-term signatures of evolutionary change in the Salmonella enterica
RT   serovar typhimurium 14028 genome.";
RL   J. Bacteriol. 192:560-567(2010).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, SECRETION VIA TYPE III SECRETION SYSTEM,
RP   AND DISRUPTION PHENOTYPE.
RX   PubMed=16177297; DOI=10.1128/iai.73.10.6260-6271.2005;
RA   Geddes K., Worley M., Niemann G., Heffron F.;
RT   "Identification of new secreted effectors in Salmonella enterica serovar
RT   Typhimurium.";
RL   Infect. Immun. 73:6260-6271(2005).
CC   -!- FUNCTION: Effector proteins function to alter host cell physiology and
CC       promote bacterial survival in host tissues. Could be required for
CC       passage of bacteria from the peritoneal cavity into the spleen, for
CC       survival and replication within host cells, or for avoiding host immune
CC       response. {ECO:0000269|PubMed:16177297}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16177297}. Host
CC       cytoplasm {ECO:0000269|PubMed:16177297}. Note=Secreted via type III
CC       secretion systems 1 and 2 (SPI-1 and SPI-2 TTSS), and delivered into
CC       the host cytoplasm. Localizes to the trans-Golgi network within both
CC       transfected and infected host epithelial cells.
CC   -!- DISRUPTION PHENOTYPE: Mutants have a competitive defect in colonization
CC       of mouse spleen. {ECO:0000269|PubMed:16177297}.
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DR   EMBL; CP001363; ACY88383.1; -; Genomic_DNA.
DR   RefSeq; WP_001147134.1; NZ_CP043402.1.
DR   AlphaFoldDB; D0ZXR5; -.
DR   EnsemblBacteria; ACY88383; ACY88383; STM14_1912.
DR   KEGG; seo:STM14_1912; -.
DR   PATRIC; fig|588858.6.peg.1820; -.
DR   HOGENOM; CLU_088946_0_0_6; -.
DR   OMA; SFEEICM; -.
DR   BioCyc; SENT588858:STM14_RS08790-MON; -.
DR   PHI-base; PHI:3749; -.
DR   Proteomes; UP000002695; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
PE   4: Predicted;
KW   Host cytoplasm; Secreted; Virulence.
FT   CHAIN           1..210
FT                   /note="Secreted effector protein SteA"
FT                   /id="PRO_0000391636"
SQ   SEQUENCE   210 AA;  23618 MW;  413279D039731780 CRC64;
     MPYTSVSTYA RALSGNKLPH VAAGDYENKL STKIMKGILY VLTAGLAYGF TRVIEHYCNV
     TPKVAEFCAN AGNIHNHLAD AVRDGLFTID VELSDGRMLT FEQLSLIAEG KPIVRISDGE
     HTVEVEGTFE EICMRLEEGF FEAPAYYDYD IDEKYKTVRE RMAAYNALPQ ALGAIPCLEY
     YIARASNMQE AKAQWAADIK ARYHNYLDNY