ID   STEEP_DANRE             Reviewed;         224 AA.
AC   Q66I61;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=STING ER exit protein {ECO:0000250|UniProtKB:Q9H5V9};
DE            Short=STEEP {ECO:0000250|UniProtKB:Q9H5V9};
GN   Name=steep1 {ECO:0000250|UniProtKB:Q9H5V9};
GN   and
GN   ORFNames=zgc:103697;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stimulates membrane curvature formation and subsequent
CC       endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K
CC       complex I, leading to COPII vesicle-mediated transport (By similarity).
CC       Promotes endoplasmic reticulum (ER) exit of cGAMP-activated STING1
CC       oligomers (By similarity). {ECO:0000250|UniProtKB:Q9H5V9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H5V9}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8VDP2}. Note=Detected in the nucleus and cell
CC       soma of various neuronal types. {ECO:0000250|UniProtKB:Q8VDP2}.
CC   -!- SIMILARITY: Belongs to the STEEP1 family. {ECO:0000305}.
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DR   EMBL; BC081515; AAH81515.1; -; mRNA.
DR   RefSeq; NP_001004659.1; NM_001004659.1.
DR   AlphaFoldDB; Q66I61; -.
DR   STRING; 7955.ENSDARP00000069117; -.
DR   PaxDb; Q66I61; -.
DR   PRIDE; Q66I61; -.
DR   GeneID; 447921; -.
DR   KEGG; dre:447921; -.
DR   CTD; 63932; -.
DR   ZFIN; ZDB-GENE-040912-104; steep1.
DR   eggNOG; KOG4397; Eukaryota.
DR   InParanoid; Q66I61; -.
DR   OrthoDB; 1161089at2759; -.
DR   PhylomeDB; Q66I61; -.
DR   PRO; PR:Q66I61; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0044297; C:cell body; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0090158; P:endoplasmic reticulum membrane organization; ISS:UniProtKB.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR   InterPro; IPR029704; STEEP-like.
DR   PANTHER; PTHR46355; PTHR46355; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..224
FT                   /note="STING ER exit protein"
FT                   /id="PRO_0000287612"
FT   REGION          191..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          172..194
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        191..217
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   224 AA;  25789 MW;  95D5137A4D40EE88 CRC64;
     MPKVVSRSVV CSDTRDREEY DDGEKPLHVY YCLCGQMVLV LDCQIEKLPM RPRDKARVID
     AAKHAHKFCN VEEDEAVYLK RSEGIERQYR KKCGKCGLLL FYQHQMKSTQ TTFIVDGALV
     KFGQGFGNTS VYSQKQETPK KVRVMMTKRT KDMGKFSSVT VSTIDEEEEE IEAREVADSY
     AQNAKVIEKQ LERKGMSKRR LQEPAELEAK KAKMKGTLID NQFK