ID   STEEP_PONAB             Reviewed;         222 AA.
AC   Q5RAT0;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=STING ER exit protein {ECO:0000250|UniProtKB:Q9H5V9};
DE            Short=STEEP {ECO:0000250|UniProtKB:Q9H5V9};
GN   Name=STEEP1 {ECO:0000250|UniProtKB:Q9H5V9};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stimulates membrane curvature formation and subsequent
CC       endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K
CC       complex I, leading to COPII vesicle-mediated transport (By similarity).
CC       Promotes endoplasmic reticulum (ER) exit of cGAMP-activated STING1
CC       oligomers (By similarity). {ECO:0000250|UniProtKB:Q9H5V9}.
CC   -!- SUBUNIT: Interacts with STING1, PIK3C3, and ATG14; the STING1/STEEP1
CC       interaction is increased upon STING1 cGAMP-activation and leads to
CC       recruitment of PI3K complex I. {ECO:0000250|UniProtKB:Q9H5V9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H5V9}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8VDP2}. Note=Detected in the nucleus and cell
CC       soma of various neuronal types. {ECO:0000250|UniProtKB:Q8VDP2}.
CC   -!- SIMILARITY: Belongs to the STEEP1 family. {ECO:0000305}.
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DR   EMBL; CR858932; CAH91130.1; -; mRNA.
DR   RefSeq; NP_001125661.1; NM_001132189.1.
DR   AlphaFoldDB; Q5RAT0; -.
DR   SMR; Q5RAT0; -.
DR   STRING; 9601.ENSPPYP00000023137; -.
DR   GeneID; 100172581; -.
DR   KEGG; pon:100172581; -.
DR   CTD; 63932; -.
DR   eggNOG; KOG4397; Eukaryota.
DR   OrthoDB; 1161089at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0044297; C:cell body; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0090158; P:endoplasmic reticulum membrane organization; ISS:UniProtKB.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR   InterPro; IPR029704; STEEP-like.
DR   PANTHER; PTHR46355; PTHR46355; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..222
FT                   /note="STING ER exit protein"
FT                   /id="PRO_0000287611"
FT   COILED          170..220
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   222 AA;  25525 MW;  586CC0CF4B5895AF CRC64;
     MPKVVSRSVV CSDTRDREEY DDGEKPLHVY YCLCGQMVLV LDCQLEKLPM RPRDRSRVID
     AAKHAHKFCN TEDEETMYLR RPEGIERQYG KKCAKCGLPL FYQSQPKNAP VTFIVDGAVV
     KFGQGFGKTN IYTQKQEPPK KVMMTKRTKD MGKFSSVTVS TIDEEEEEIE AREVADSYAQ
     NAKVIEKQLE RKGMSKRRLQ ELAELEAKKA KMKGTLIDNQ FK