ID   STEEP_XENLA             Reviewed;         222 AA.
AC   Q5U515; Q7ZX08;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=STING ER exit protein {ECO:0000250|UniProtKB:Q9H5V9};
DE            Short=STEEP {ECO:0000250|UniProtKB:Q9H5V9};
GN   Name=steep1 {ECO:0000250|UniProtKB:Q9H5V9};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stimulates membrane curvature formation and subsequent
CC       endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K
CC       complex I, leading to COPII vesicle-mediated transport (By similarity).
CC       Promotes endoplasmic reticulum (ER) exit of cGAMP-activated STING1
CC       oligomers (By similarity). {ECO:0000250|UniProtKB:Q9H5V9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H5V9}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8VDP2}. Note=Detected in the nucleus and cell
CC       soma of various neuronal types. {ECO:0000250|UniProtKB:Q8VDP2}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5U515-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5U515-2; Sequence=VSP_025570;
CC   -!- SIMILARITY: Belongs to the STEEP1 family. {ECO:0000305}.
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DR   EMBL; BC046270; AAH46270.1; -; mRNA.
DR   EMBL; BC084870; AAH84870.1; -; mRNA.
DR   RefSeq; NP_001079192.1; NM_001085723.1. [Q5U515-1]
DR   AlphaFoldDB; Q5U515; -.
DR   SMR; Q5U515; -.
DR   DNASU; 373791; -.
DR   GeneID; 373791; -.
DR   KEGG; xla:373791; -.
DR   CTD; 373791; -.
DR   Xenbase; XB-GENE-5808712; steep1.L.
DR   OrthoDB; 1161089at2759; -.
DR   Proteomes; UP000186698; Chromosome 8S.
DR   Bgee; 373791; Expressed in gastrula and 19 other tissues.
DR   GO; GO:0044297; C:cell body; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0090158; P:endoplasmic reticulum membrane organization; ISS:UniProtKB.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR   InterPro; IPR029704; STEEP-like.
DR   PANTHER; PTHR46355; PTHR46355; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..222
FT                   /note="STING ER exit protein"
FT                   /id="PRO_0000287613"
FT   COILED          170..220
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         143..222
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_025570"
SQ   SEQUENCE   222 AA;  25493 MW;  07DE43334AE60DC5 CRC64;
     MPKVVSRSVV CSDTRDREEY DDGEKPLHVY YCLCGQMVLV LDCQLEKLPM RPRDRARVIG
     AAKHAHKFCN TEEEEPVYLR RSDGIERQYR KKCSKCSLLL FYQHSQKNAA ATFIVNGALV
     KFGQGFGKTS IYTQKPDPPK KVMMTKRTKD MGKFSSVTVS TIDEEEEEIE AREVADSYAQ
     NAKVIEKQLE RKGMSKRRLQ ELAELEAKKA KMKGTLIDNQ FK