ID   STEEP_XENTR             Reviewed;         222 AA.
AC   Q6P338;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=STING ER exit protein {ECO:0000250|UniProtKB:Q9H5V9};
DE            Short=STEEP {ECO:0000250|UniProtKB:Q9H5V9};
GN   Name=steep1 {ECO:0000250|UniProtKB:Q9H5V9};
GN   and
GN   ORFNames=TNeu084h20.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stimulates membrane curvature formation and subsequent
CC       endoplasmic reticulum exit site (ERES) establishment by recruiting PI3K
CC       complex I, leading to COPII vesicle-mediated transport (By similarity).
CC       Promotes endoplasmic reticulum (ER) exit of cGAMP-activated STING1
CC       oligomers (By similarity). {ECO:0000250|UniProtKB:Q9H5V9}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H5V9}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8VDP2}. Note=Detected in the nucleus and cell
CC       soma of various neuronal types. {ECO:0000250|UniProtKB:Q8VDP2}.
CC   -!- SIMILARITY: Belongs to the STEEP1 family. {ECO:0000305}.
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DR   EMBL; CR760470; CAJ82416.1; -; mRNA.
DR   EMBL; BC064195; AAH64195.1; -; mRNA.
DR   EMBL; BC084906; AAH84906.1; -; mRNA.
DR   RefSeq; NP_989343.1; NM_204012.2.
DR   RefSeq; XP_017951679.1; XM_018096190.1.
DR   AlphaFoldDB; Q6P338; -.
DR   SMR; Q6P338; -.
DR   STRING; 8364.ENSXETP00000044925; -.
DR   PaxDb; Q6P338; -.
DR   DNASU; 394969; -.
DR   GeneID; 394969; -.
DR   KEGG; xtr:394969; -.
DR   CTD; 63932; -.
DR   Xenbase; XB-GENE-5808638; steep1.
DR   eggNOG; KOG4397; Eukaryota.
DR   HOGENOM; CLU_099571_1_0_1; -.
DR   InParanoid; Q6P338; -.
DR   OMA; NCRNCNL; -.
DR   OrthoDB; 1161089at2759; -.
DR   PhylomeDB; Q6P338; -.
DR   TreeFam; TF300272; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000020806; Expressed in heart and 14 other tissues.
DR   ExpressionAtlas; Q6P338; baseline.
DR   GO; GO:0044297; C:cell body; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0090158; P:endoplasmic reticulum membrane organization; ISS:UniProtKB.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR   InterPro; IPR029704; STEEP-like.
DR   PANTHER; PTHR46355; PTHR46355; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..222
FT                   /note="STING ER exit protein"
FT                   /id="PRO_0000287614"
FT   COILED          170..220
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   222 AA;  25589 MW;  20A7BFD8A533B94B CRC64;
     MPKVVSRSVV CSDTRDREEY DDGEKPLHVY YCLCGQMVLV LDCQLEKLPM RPRDKARVID
     AAKHAHKFCN TEEEEPVYLR RPDGIERQYR KKCSKCSLLL FYQHSQKNVA ATFIVNGALV
     KFGQGFGKTN IYTQKPDPPK KVMMTKRTKD MGKFSSVTVS TIDEEEEEIE AREVADSYAQ
     NAKVIEKQLE RKGMSKRRLQ ELAELEAKKA KMKGTLIDNQ FK