STF1_YEAST
ID STF1_YEAST Reviewed; 86 AA.
AC P01098; D6VRL9;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 2.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=ATPase-stabilizing factor 9 kDa, mitochondrial {ECO:0000305};
DE AltName: Full=ATP synthase F1 subunit epsilon {ECO:0000250|UniProtKB:Q9UII2};
DE Flags: Precursor;
GN Name=STF1; Synonyms=AIS2; OrderedLocusNames=YDL130W-A; ORFNames=YDL130BW;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2907329; DOI=10.1093/oxfordjournals.jbchem.a122504;
RA Tagawa K., Imamoto F.;
RT "Molecular cloning and expression of a gene for a factor which stabilizes
RT formation of inhibitor-mitochondrial ATPase complex from Saccharomyces
RT cerevisiae.";
RL J. Biochem. 104:526-530(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP PROTEIN SEQUENCE OF 24-86.
RX PubMed=6194151; DOI=10.1093/oxfordjournals.jbchem.a134347;
RA Matsubara H., Inoue K., Hashimoto T., Yoshida Y., Tagawa K.;
RT "A stabilizing factor of yeast mitochondrial F1F0-ATPase-inhibitor complex:
RT common amino acid sequence with yeast ATPase inhibitor and E. coli epsilon
RT and bovine delta subunits.";
RL J. Biochem. 94:315-318(1983).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
CC -!- FUNCTION: This is 1 of 2 proteins that can stabilize the ATPase-
CC inhibitor complex, which normally dissociates when externally added ATP
CC has been consumed.
CC -!- SUBCELLULAR LOCATION: Mitochondrion.
CC -!- SIMILARITY: Belongs to the ATPase inhibitor family. {ECO:0000305}.
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DR EMBL; D00347; BAA00256.1; -; Genomic_DNA.
DR EMBL; Z74178; CAA98699.1; -; Genomic_DNA.
DR EMBL; Z74179; CAA98701.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA11729.1; -; Genomic_DNA.
DR PIR; JX0048; IWBY9.
DR RefSeq; NP_010152.1; NM_001184325.1.
DR AlphaFoldDB; P01098; -.
DR SMR; P01098; -.
DR BioGRID; 31932; 65.
DR IntAct; P01098; 1.
DR MINT; P01098; -.
DR STRING; 4932.YDL130W-A; -.
DR iPTMnet; P01098; -.
DR MaxQB; P01098; -.
DR PaxDb; P01098; -.
DR PRIDE; P01098; -.
DR TopDownProteomics; P01098; -.
DR EnsemblFungi; YDL130W-A_mRNA; YDL130W-A; YDL130W-A.
DR GeneID; 851426; -.
DR KEGG; sce:YDL130W-A; -.
DR SGD; S000007232; STF1.
DR VEuPathDB; FungiDB:YDL130W-A; -.
DR eggNOG; ENOG502SCJG; Eukaryota.
DR GeneTree; ENSGT00940000176616; -.
DR HOGENOM; CLU_145563_4_0_1; -.
DR InParanoid; P01098; -.
DR OMA; RCISRNT; -.
DR BioCyc; YEAST:G3O-30085-MON; -.
DR PRO; PR:P01098; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; P01098; protein.
DR GO; GO:0005739; C:mitochondrion; IDA:SGD.
DR GO; GO:0051117; F:ATPase binding; IDA:SGD.
DR GO; GO:0042030; F:ATPase inhibitor activity; IEA:InterPro.
DR GO; GO:0032780; P:negative regulation of ATP-dependent activity; IDA:SGD.
DR InterPro; IPR007648; ATPase_inhibitor_mt.
DR Pfam; PF04568; IATP; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Mitochondrion; Phosphoprotein;
KW Reference proteome; Transit peptide.
FT TRANSIT 1..23
FT /note="Mitochondrion"
FT /evidence="ECO:0000269|PubMed:6194151"
FT CHAIN 24..86
FT /note="ATPase-stabilizing factor 9 kDa, mitochondrial"
FT /id="PRO_0000002555"
FT MOD_RES 24
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18407956"
SQ SEQUENCE 86 AA; 10062 MW; 3FF1E659BD994066 CRC64;
MLNRCISRNT RLPVNLRIAS RFYSDGPLGG AGPGNPQDIF IKRERAKEDY YARQQEREQL
AHVKEQLKEH KKKLENLENK INNLSK
