STF3_MYCBO
ID STF3_MYCBO Reviewed; 388 AA.
AC P64964; A0A1R3Y0P7; Q50695; X2BJR9;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=PAPS-dependent sulfotransferase Stf3 {ECO:0000250|UniProtKB:P9WLG1};
DE EC=2.8.2.- {ECO:0000250|UniProtKB:P9WLG1};
GN Name=stf3 {ECO:0000250|UniProtKB:P9WLG1}; OrderedLocusNames=BQ2027_MB2290C;
OS Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=233413;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT "The complete genome sequence of Mycobacterium bovis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA Robbe-Austerman S., Gordon S.V.;
RT "Updated reference genome sequence and annotation of Mycobacterium bovis
RT AF2122/97.";
RL Genome Announc. 5:E00157-E00157(2017).
CC -!- FUNCTION: Required for the sulfation of S881. S881 is a sulfated
CC menaquinone, which is localized in the outer envelope of M.bovis and
CC negatively regulates its virulence. 3'-phosphoadenosine-5'-
CC phosphosulfate (PAPS) is the sulfate donor.
CC {ECO:0000250|UniProtKB:P9WLG1}.
CC -!- SIMILARITY: Belongs to the Stf3 family. {ECO:0000305}.
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DR EMBL; LT708304; SIU00901.1; -; Genomic_DNA.
DR RefSeq; NP_855939.1; NC_002945.3.
DR RefSeq; WP_003411661.1; NC_002945.4.
DR AlphaFoldDB; P64964; -.
DR SMR; P64964; -.
DR EnsemblBacteria; SIU00901; SIU00901; BQ2027_MB2290C.
DR GeneID; 45426249; -.
DR PATRIC; fig|233413.5.peg.2515; -.
DR OMA; FILGHWR; -.
DR Proteomes; UP000001419; Chromosome.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 3: Inferred from homology;
KW Transferase.
FT CHAIN 1..388
FT /note="PAPS-dependent sulfotransferase Stf3"
FT /id="PRO_0000103994"
SQ SEQUENCE 388 AA; 46062 MW; 5DED0263275A9B24 CRC64;
MKALRSSSRL SRWREWAAPL WVGCNFSAWM RLLIRNRFAV HHSRWHFAVL YTFLSMVNSC
LGLWQKIVFG RRVAETVIAD PPIFIVGHWR TGTTLLHELL VVDDRHTGPT GYECLAPHHF
LLTEWFAPYV EFLVSKHRAM DNMDLSLHHP QEDEFVWCMQ GLPSPYLTIA FPNRPPQYEE
YLDLEQVAPR ELEIWKRTLF RFVQQVYFRR RKTVILKNPT HSFRIKVLLE VFPQAKFIHI
VRDPYVVYPS TIHLHKALYR IHGLQQPTFD GLDDKVVSTY VDLYRKLDEG RELVDPTRFY
ELRYEDLIGD PEGQLRRLYQ HLGLGDFECY LPRLRQYLAD HADYKTNSYQ LTVEQRAIVD
EHWGEIIDRY GYDRHTPEPA RLRPAVGG