ID   STF3_MYCTO              Reviewed;         388 AA.
AC   P9WLG0; L0TAP1; P64963; Q50695;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=PAPS-dependent sulfotransferase Stf3 {ECO:0000250|UniProtKB:P9WLG1};
DE            EC=2.8.2.- {ECO:0000250|UniProtKB:P9WLG1};
GN   Name=stf3 {ECO:0000250|UniProtKB:P9WLG1}; OrderedLocusNames=MT2329;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Required for the sulfation of S881. S881 is a sulfated
CC       menaquinone, which is localized in the outer envelope of M.tuberculosis
CC       and negatively regulates its virulence. 3'-phosphoadenosine-5'-
CC       phosphosulfate (PAPS) is the sulfate donor.
CC       {ECO:0000250|UniProtKB:P9WLG1}.
CC   -!- SIMILARITY: Belongs to the Stf3 family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK46611.1; -; Genomic_DNA.
DR   PIR; G70729; G70729.
DR   RefSeq; WP_003411661.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WLG0; -.
DR   SMR; P9WLG0; -.
DR   EnsemblBacteria; AAK46611; AAK46611; MT2329.
DR   GeneID; 45426249; -.
DR   KEGG; mtc:MT2329; -.
DR   PATRIC; fig|83331.31.peg.2504; -.
DR   HOGENOM; CLU_051167_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   Transferase.
FT   CHAIN           1..388
FT                   /note="PAPS-dependent sulfotransferase Stf3"
FT                   /id="PRO_0000427485"
SQ   SEQUENCE   388 AA;  46062 MW;  5DED0263275A9B24 CRC64;
     MKALRSSSRL SRWREWAAPL WVGCNFSAWM RLLIRNRFAV HHSRWHFAVL YTFLSMVNSC
     LGLWQKIVFG RRVAETVIAD PPIFIVGHWR TGTTLLHELL VVDDRHTGPT GYECLAPHHF
     LLTEWFAPYV EFLVSKHRAM DNMDLSLHHP QEDEFVWCMQ GLPSPYLTIA FPNRPPQYEE
     YLDLEQVAPR ELEIWKRTLF RFVQQVYFRR RKTVILKNPT HSFRIKVLLE VFPQAKFIHI
     VRDPYVVYPS TIHLHKALYR IHGLQQPTFD GLDDKVVSTY VDLYRKLDEG RELVDPTRFY
     ELRYEDLIGD PEGQLRRLYQ HLGLGDFECY LPRLRQYLAD HADYKTNSYQ LTVEQRAIVD
     EHWGEIIDRY GYDRHTPEPA RLRPAVGG