ID   STHA_PECCC              Reviewed;         150 AA.
AC   P71317;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Soluble pyridine nucleotide transhydrogenase;
DE            Short=STH;
DE            EC=1.6.1.1;
DE   AltName: Full=NAD(P)(+) transhydrogenase [B-specific];
DE   Flags: Fragment;
GN   Name=sthA; Synonyms=udhA;
OS   Pectobacterium carotovorum subsp. carotovorum (Erwinia carotovora subsp.
OS   carotovora).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Pectobacterium.
OX   NCBI_TaxID=555;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=71;
RX   PubMed=9809430; DOI=10.1111/j.1574-6968.1998.tb13242.x;
RA   Calcutt M.J., Lewis M.S., Eisenstark A.;
RT   "The oxyR gene from Erwinia carotovora: cloning, sequence analysis and
RT   expression in Escherichia coli.";
RL   FEMS Microbiol. Lett. 167:295-301(1998).
CC   -!- FUNCTION: Conversion of NADPH, generated by peripheral catabolic
CC       pathways, to NADH, which can enter the respiratory chain for energy
CC       generation. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NAD(+) + NADPH = NADH + NADP(+); Xref=Rhea:RHEA:11692,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57783, ChEBI:CHEBI:57945,
CC         ChEBI:CHEBI:58349; EC=1.6.1.1;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC       Note=Binds 1 FAD per subunit. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class-I pyridine nucleotide-disulfide
CC       oxidoreductase family. {ECO:0000305}.
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DR   EMBL; U74302; AAC72240.1; -; Genomic_DNA.
DR   AlphaFoldDB; P71317; -.
DR   SMR; P71317; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0003957; F:NAD(P)+ transhydrogenase (B-specific) activity; IEA:UniProtKB-EC.
DR   GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR   Gene3D; 3.30.390.30; -; 1.
DR   InterPro; IPR016156; FAD/NAD-linked_Rdtase_dimer_sf.
DR   InterPro; IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
DR   Pfam; PF02852; Pyr_redox_dim; 1.
DR   SUPFAM; SSF55424; SSF55424; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; FAD; Flavoprotein; NAD; NADP; Oxidoreductase.
FT   CHAIN           <1..150
FT                   /note="Soluble pyridine nucleotide transhydrogenase"
FT                   /id="PRO_0000068064"
FT   NON_TER         1
SQ   SEQUENCE   150 AA;  16451 MW;  90E962952FB2C2A1 CRC64;
     SLASAAYDQG RLAAQAIIKG DASAHLIEDI PTGIYTIPEI SSVGKTEQEL TAMKVPYEVG
     RAQFKHLARA QIVGMNVGSL KILFHRETKQ ILGIHCFGER AAEIIHIGQA IMEQKGEGNT
     IEYFVNTTFN YPTMAEAYRV AALNGLNRLF