ID   STHR_PHANO              Reviewed;         427 AA.
AC   Q0UK54;
DT   11-DEC-2019, integrated into UniProtKB/Swiss-Prot.
DT   11-DEC-2019, sequence version 2.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Stemphyloxin II biosynthesis cluster transcription factor sthR {ECO:0000303|PubMed:31553484};
DE   AltName: Full=Stemphyloxin II biosynthesis cluster regulator {ECO:0000303|PubMed:31553484};
GN   Name=sthR {ECO:0000303|PubMed:31553484}; ORFNames=SNOG_07860;
OS   Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume
OS   blotch fungus) (Parastagonospora nodorum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Phaeosphaeriaceae;
OC   Parastagonospora.
OX   NCBI_TaxID=321614;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SN15 / ATCC MYA-4574 / FGSC 10173;
RX   PubMed=18024570; DOI=10.1105/tpc.107.052829;
RA   Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L.,
RA   Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E.,
RA   Torriani S.F.F., McDonald B.A., Oliver R.P.;
RT   "Dothideomycete-plant interactions illuminated by genome sequencing and EST
RT   analysis of the wheat pathogen Stagonospora nodorum.";
RL   Plant Cell 19:3347-3368(2007).
RN   [2]
RP   FUNCTION.
RX   PubMed=31553484; DOI=10.1002/chem.201904360;
RA   Li H., Hu J., Wei H., Solomon P.S., Stubbs K.A., Chooi Y.H.;
RT   "Biosynthesis of a Tricyclo[6.2.2.02,7]dodecane System by a Berberine
RT   Bridge Enzyme-like Intramolecular Aldolase.";
RL   Chemistry 25:15062-15066(2019).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       gene cluster that mediates the biosynthesis of the phytotoxin
CC       stemphyloxin II. {ECO:0000269|PubMed:31553484}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAT85326.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CH445335; EAT85326.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_001798187.1; XM_001798135.1.
DR   AlphaFoldDB; Q0UK54; -.
DR   GeneID; 5975080; -.
DR   KEGG; pno:SNOG_07860; -.
DR   eggNOG; ENOG502RJXI; Eukaryota.
DR   HOGENOM; CLU_696583_0_0_1; -.
DR   InParanoid; Q0UK54; -.
DR   OrthoDB; 1576792at2759; -.
DR   Proteomes; UP000001055; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..427
FT                   /note="Stemphyloxin II biosynthesis cluster transcription
FT                   factor sthR"
FT                   /id="PRO_0000448658"
FT   DNA_BIND        15..45
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          51..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   427 AA;  46950 MW;  976FA0D54098F375 CRC64;
     MSTISFFATS KRTSCDRCRK QKLRCPPDKD DMGTCGRCLR AGVACATSYT KPRGRSQKHG
     ISTDGTSHVS GLDMQEPALP TPESVLSAGL TSSVQVAEDG SQLWSPLEEY NHLPSLSNFE
     SGALSQSQDE DFAGLWWSPL HEDLDLDVHM DPSGACQNGY SAEISSFSRT DCSRQSNDCS
     PETLQHVECD MRLSQLNLEL CRQSKAYHHW PNTTSDGSVR RPHFAIASAL RDLLQNTEAF
     IHILHCLRNG TELNLDGRYQ EPISTHDTGV SPPSLAFPSI LNLTSCFFRI VDLFNVLLSS
     LALELATHSP LQRRSSSSSV TSALQILPDL KLAGLAVQEV SLQTKILVLT ITHHFETMER
     LLGLPADLRV SECKDDNGYG LLGASWTSVL SSGRREKFEL GWRRTGNWVT SIESLKANMG
     TLTKGSC