STI1_SCHPO
ID STI1_SCHPO Reviewed; 591 AA.
AC Q9USI5; O13458;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 152.
DE RecName: Full=Heat shock protein sti1 homolog;
GN Name=sti1; Synonyms=stil; ORFNames=SPCC645.14c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Yamashita Y., Nakaseko Y., Samejima I., Kumada K., Yamada H., Yanagida M.;
RL Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: May play a role in mediating the heat shock response of some
CC HSP70 genes. {ECO:0000250}.
CC -!- SUBUNIT: Part of a larger complex that includes HSP70, HSP90, and
CC immunophilins. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR EMBL; D85197; BAA22619.1; -; Genomic_DNA.
DR EMBL; CU329672; CAB39910.1; -; Genomic_DNA.
DR PIR; T41531; T41531.
DR PIR; T51996; T51996.
DR RefSeq; NP_588123.1; NM_001023113.2.
DR AlphaFoldDB; Q9USI5; -.
DR SMR; Q9USI5; -.
DR BioGRID; 276037; 6.
DR STRING; 4896.SPCC645.14c.1; -.
DR iPTMnet; Q9USI5; -.
DR SwissPalm; Q9USI5; -.
DR MaxQB; Q9USI5; -.
DR PaxDb; Q9USI5; -.
DR PRIDE; Q9USI5; -.
DR EnsemblFungi; SPCC645.14c.1; SPCC645.14c.1:pep; SPCC645.14c.
DR GeneID; 2539474; -.
DR KEGG; spo:SPCC645.14c; -.
DR PomBase; SPCC645.14c; sti1.
DR VEuPathDB; FungiDB:SPCC645.14c; -.
DR eggNOG; KOG0548; Eukaryota.
DR HOGENOM; CLU_000134_46_5_1; -.
DR InParanoid; Q9USI5; -.
DR OMA; HYSKAWE; -.
DR PhylomeDB; Q9USI5; -.
DR Reactome; R-SPO-3371497; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand.
DR Reactome; R-SPO-9696273; RND1 GTPase cycle.
DR PRO; PR:Q9USI5; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0032991; C:protein-containing complex; NAS:PomBase.
DR GO; GO:0042030; F:ATPase inhibitor activity; IDA:PomBase.
DR GO; GO:0030544; F:Hsp70 protein binding; IEA:InterPro.
DR GO; GO:0051879; F:Hsp90 protein binding; IBA:GO_Central.
DR GO; GO:0006457; P:protein folding; ISO:PomBase.
DR Gene3D; 1.25.40.10; -; 3.
DR InterPro; IPR041243; STI1.
DR InterPro; IPR045248; Sti1-like.
DR InterPro; IPR006636; STI1_HS-bd.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR22904; PTHR22904; 1.
DR Pfam; PF17830; STI1; 2.
DR Pfam; PF13181; TPR_8; 2.
DR SMART; SM00727; STI1; 2.
DR SMART; SM00028; TPR; 8.
DR SUPFAM; SSF48452; SSF48452; 3.
DR PROSITE; PS50005; TPR; 8.
DR PROSITE; PS50293; TPR_REGION; 3.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome; Repeat; Stress response; TPR repeat.
FT CHAIN 1..591
FT /note="Heat shock protein sti1 homolog"
FT /id="PRO_0000106342"
FT REPEAT 2..35
FT /note="TPR 1"
FT REPEAT 36..69
FT /note="TPR 2"
FT REPEAT 70..103
FT /note="TPR 3"
FT DOMAIN 139..178
FT /note="STI1 1"
FT REPEAT 265..298
FT /note="TPR 4"
FT REPEAT 299..331
FT /note="TPR 5"
FT REPEAT 339..372
FT /note="TPR 6"
FT REPEAT 399..432
FT /note="TPR 7"
FT REPEAT 433..466
FT /note="TPR 8"
FT REPEAT 467..500
FT /note="TPR 9"
FT DOMAIN 530..569
FT /note="STI1 2"
FT REGION 202..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 28
FT /note="A -> T (in Ref. 1; BAA22619)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 591 AA; 65545 MW; D218FCCD5884B4AA CRC64;
MAEELKAKGN AAFSKKDYKT AIDYFTQAIG LDERNHILYS NRSACYASEK DYADALKDAT
KCTELKPDWA KGWSRKGAAL HGLGDLDAAR SAYEEGLKHD ANNAQLLNGL KSVEAAQTQA
ASGAGGFNPF AKLGSQLSDP KFMEKLASNP ETASLLADSA FMAKLQKIQQ NPGSIMAELN
DPRMMKVIGM LMGIDINMNA GEGAAEEQEK KEEFAPSSST PSADSAKPET TNPPPQPQAS
EPMEEDKTAE ELEEAATKEA LKKKADQEKQ IGNENYKKRN FPVAIEQYKK AWDTYKDITY
LNNLAAAYFE ADQLDDCIKT CEDAIEQGRE LRADFKLIAK ALGRLGTTYQ KRGDLVKAID
YYQRSLTEHR TPDILSRLKD AEKSKELQDR EAYIDPDKAE ESRVKGNELF KSGDFANAIK
EYTEMTKRAP SDPRGFGNRA AAYLKVMAPA ECIRDCNKAI ELDPNFAKAY VRKAQALFML
KDYNKCIDAC NEASEVDRRE PNTGKNLREI ESQLSKCMSA MASQRQNETE EETMARIQKD
PEVLGILQDP AMQAILGQAR ENPAALMEHM KNPTVKSKIE KLIASGVIRL G
