ID   STIL4_ARATH             Reviewed;         966 AA.
AC   F4KEM0; Q1PDM8; Q5XV23; Q9FK71;
DT   24-JUL-2013, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Protein STICHEL-like 4;
GN   OrderedLocusNames=At5g45720; ORFNames=MRA19.13;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9734815; DOI=10.1093/dnares/5.3.203;
RA   Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence
RT   features of the regions of 1,367,185 bp covered by 19 physically assigned
RT   P1 and TAC clones.";
RL   DNA Res. 5:203-216(1998).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Xiao Y.-L., Underwood B.A., Moskal W.A. Jr., Wang W., Redman J.C., Wu H.C.,
RA   Utterback T., Town C.D.;
RT   "Reconstruction of cDNA sequences for hypothetical genes in Arabidopsis
RT   thaliana from 5' and 3' RACE products.";
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-539.
RC   STRAIN=cv. Columbia;
RX   PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA   Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT   "Simultaneous high-throughput recombinational cloning of open reading
RT   frames in closed and open configurations.";
RL   Plant Biotechnol. J. 4:317-324(2006).
RN   [5]
RP   GENE FAMILY.
RX   PubMed=12586888; DOI=10.1104/pp.014209;
RA   Ilgenfritz H., Bouyer D., Schnittger A., Mathur J., Kirik V., Schwab B.,
RA   Chua N.H., Juergens G., Huelskamp M.;
RT   "The Arabidopsis STICHEL gene is a regulator of trichome branch number and
RT   encodes a novel protein.";
RL   Plant Physiol. 131:643-655(2003).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences.;
CC       Name=1;
CC         IsoId=F4KEM0-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the DnaX/STICHEL family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAU44569.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};
CC       Sequence=ABE66222.1; Type=Miscellaneous discrepancy; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC       Sequence=BAB09214.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AB012245; BAB09214.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; AED95288.1; -; Genomic_DNA.
DR   EMBL; AY735699; AAU44569.1; ALT_SEQ; mRNA.
DR   EMBL; DQ447040; ABE66222.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_199384.2; NM_123939.3. [F4KEM0-1]
DR   AlphaFoldDB; F4KEM0; -.
DR   SMR; F4KEM0; -.
DR   STRING; 3702.AT5G45720.1; -.
DR   iPTMnet; F4KEM0; -.
DR   PaxDb; F4KEM0; -.
DR   PRIDE; F4KEM0; -.
DR   EnsemblPlants; AT5G45720.1; AT5G45720.1; AT5G45720. [F4KEM0-1]
DR   GeneID; 834611; -.
DR   Gramene; AT5G45720.1; AT5G45720.1; AT5G45720. [F4KEM0-1]
DR   KEGG; ath:AT5G45720; -.
DR   Araport; AT5G45720; -.
DR   TAIR; locus:2172013; AT5G45720.
DR   eggNOG; KOG0989; Eukaryota.
DR   InParanoid; F4KEM0; -.
DR   OMA; RECDIVN; -.
DR   OrthoDB; 97895at2759; -.
DR   PRO; PR:F4KEM0; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; F4KEM0; baseline and differential.
DR   GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR   GO; GO:0005663; C:DNA replication factor C complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR   GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR   CDD; cd18137; HLD_clamp_pol_III_gamma_tau; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR   InterPro; IPR022754; DNA_pol_III_gamma-3.
DR   InterPro; IPR012763; DNA_pol_III_sug/sutau_N.
DR   InterPro; IPR045085; HLD_clamp_pol_III_gamma_tau.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF12169; DNA_pol3_gamma3; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF48019; SSF48019; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR02397; dnaX_nterm; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; ATP-binding; Coiled coil; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..966
FT                   /note="Protein STICHEL-like 4"
FT                   /id="PRO_0000422980"
FT   REGION          64..118
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          200..237
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          706..733
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          650..678
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        71..90
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..108
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         384..391
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        6
FT                   /note="S -> F (in Ref. 4; ABE66222)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   966 AA;  108143 MW;  6FD931214A7C6B8C CRC64;
     MSRVASSRVL KDSNGDIGEH LRNHIHLTNC IHLKNHMHNN NKQSPVLTDR SLLMRDLVVL
     QRSRSLRDPS ASPNLKEDHQ DSREGRRRSG LRLSGSSPIV SFGTSKVTPS DEKFDRSSRK
     SYRVEEVNEV YSVPSVKSVS KDRINKKVNE AIVKTLSDQL NEVGGDSDDL VSCNVRPRGD
     GCRRRKFRGT RRAGRAVNVR DNAAGNESEM SIASNSVPRG EKYEGEEGGG GRDREQNMSC
     GIPFNWSRIH HRGKTFLDIA GRSLSCGISD SKGRKGEAGT PMFSDSSSSD REALPLLVDS
     ADNEEWVHDY SGELGIFADN LLKNGKDSVI GKKSSRKNTR WHQSFTQKYA PRTFRDLLGQ
     NLVVQALSNA IAKRRVGLLY VFHGPNGTGK TSCARVFARA LNCHSTEQSK PCGVCSSCVS
     YDDGKNRYIR EMGPVKSFDF ENLLDKTNIR QQQKQQLVLI FDDCDTMSTD CWNTLSKIVD
     RAPRRVVFVL VCSSLDVLPH IIVSRCQKFF FPKLKDVDII DSLQLIASKE EIDIDKDALK
     LVASRSDGSL RDAEMTLEQL SLLGTRISVP LVQEMVGLIS DEKLVDLLDL ALSADTVNTV
     KNLRIIMETG LEPLALMSQL ATVITDILAG SYDFTKDQCK RKFFRRQPLS KEDMEKLKQA
     LKTLSESEKQ LRVSNDKLTW LTAALLQLAP DKQYLLPHSS SADASFNHTP LTDSDPSNHV
     VAGTRRDDSK QGFSCKNRPS VEDIWLAVIE NVRVNGLREF LYKEGKIFSI SIGSAPMVQL
     MFNSPIAKST AENFEEHILK AFEAVLGSPV TLEMRTESKK DLGFSSLQGL SNGERFRESG
     RSEIVEVADS ESPMTRVRRK HLEASQNQNQ NQNQSIVRGK VSLAQVIKQA EGNSWSKHKA
     VEIANKLEQE NLKLEPRSRS LICWKASRST RRKLSRLKVR TRKLRLHSLL KLVSCGKCLS
     TRSPPR