ID   STIL_XENLA              Reviewed;        1281 AA.
AC   Q4V7H1; Q6NRI9;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 41.
DE   RecName: Full=SCL-interrupting locus protein homolog;
GN   Name=stil;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an essential role in early embryonic development. Plays
CC       an important role in the regulation of centriole duplication.
CC       {ECO:0000250|UniProtKB:Q15468, ECO:0000250|UniProtKB:Q8JGS1}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome, centriole
CC       {ECO:0000250|UniProtKB:Q15468}.
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DR   EMBL; BC070761; AAH70761.1; -; mRNA.
DR   EMBL; BC097918; AAH97918.1; -; mRNA.
DR   RefSeq; NP_001084821.1; NM_001091352.1.
DR   AlphaFoldDB; Q4V7H1; -.
DR   SMR; Q4V7H1; -.
DR   PRIDE; Q4V7H1; -.
DR   DNASU; 431864; -.
DR   GeneID; 431864; -.
DR   KEGG; xla:431864; -.
DR   CTD; 431864; -.
DR   Xenbase; XB-GENE-975755; stil.L.
DR   OrthoDB; 342602at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 431864; Expressed in egg cell and 18 other tissues.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0046599; P:regulation of centriole replication; ISS:UniProtKB.
DR   InterPro; IPR026123; Sil.
DR   PANTHER; PTHR15128; PTHR15128; 1.
DR   Pfam; PF15253; STIL_N; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Developmental protein; Reference proteome.
FT   CHAIN           1..1281
FT                   /note="SCL-interrupting locus protein homolog"
FT                   /id="PRO_0000271334"
FT   REGION          390..431
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          450..592
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          765..790
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          879..915
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        404..418
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        450..478
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        499..516
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        524..592
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        766..790
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        888..915
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1281 AA;  140986 MW;  28E973BC917608BD CRC64;
     MSTSINLKNT QFYKEVRGVS MENQRNLRSM SNRMLSVNFP PSKCALWDPA PMGDPFGLHF
     SYYRNPRLLV SEKALRLSSR HAKTGRKPFS CFLLGTFSVD EDEEGVTLTV DRFDPGREKT
     GSGSSKVPTA QLPGDFIIPC TISIGKGSNN VIVHTPEDFT SSFMSLQSHL HGKEALDLAK
     LLAMRAHITY TENMDNLHFD LHWAAVTVAN TFESTPIKPV PIIPTALARN LGSHNNIAHL
     QGTHKSGYLT MDQTRKLLLV LESDPKVYML PLVGIWLSGI THIHSPQVWA ACLRYIFSSS
     IHERVLSESG SFLIILYSLT HKEPEFYECS PCVKHDPLGF QLLTCQDTLH LFKNAEVSKN
     PLLRFELSSE CQELEADLFN ETCKNKSTTV FKQSPLPNKL STSDHDSGVE EEDFSPRPSP
     RPHPSVQQVS RIHPSVPELS LVFSSFFDPK SASHNPENRT RNNSPFSSTP QNVNNMFAGA
     PKPNKEPQPC DNQASGLLPR PAPSLNTNST AMKPSKVKSS PADYQPPHLQ SSNQIRRNST
     STSSAFSTPR SGCSPDSTVH QVKGSCEQEQ NINGSAQPQG TTPLMRSGSY SRQVSSNFPN
     HNVTFPLHSR HVAEVAKPSP NLAPFHQTNV CTSCHSLVSC HSKNCWPAMG HLTYHTMENP
     PETCESVMPA YQNVVCPSVC CPQTAGKTEF CSPVDLVLLS PGRRDSLPLN PCSPHTCRHT
     PPPVIPTATG MLGLSTEAYR LFAEQDKQLK LLQAQIQRLL EAQAAESEPS KTTIPNNSKQ
     KQVESVSTEQ EIKTSVSIAV STGASLFWNP PCPEKEESMD KQDDSAFCNE FSVNVNTEDT
     SHATITSSIR AVDIHSFSES TQLTDRGNCT ASLHVSHERD DASYPLPDVQ QDINNSKSLS
     NQTDHTESPN TAEIDSGVSA VPPEKFYQDL LAQVNNLLKT SSTEDEMTST KIDSGHIIEK
     TESLPCNPTE NNDKNVLKAT LKQLKSLGVN IDMNTSELQA TKADTADSAS ILACINPEAV
     IPRLNYMSFS NIGLSGFVPN GVDLSMEANA IALKYLNESQ LNQLSLSHAN KNKQSDSISY
     NSLLPGTTEK SMVGLSLISP SNMSFATKKY MKRYGLIESS DSSMEEPDLA NASSFALTPM
     SSDSTSENRL FFNDSCKDGN FVTCEEQKRK NADVDSAIGW AHHPETNKLR NITNEISGKL
     INVAPLQEDR PLHFLKDLKA RTKLSAGKAQ FTQHPEKENT GDVQFFHEKH DGFSGKKSLG
     GPSTVGDILD VNRLRQLPKL F