STIMA_RAT
ID STIMA_RAT Reviewed; 288 AA.
AC Q7TSW6;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Store-operated calcium entry regulator STIMATE {ECO:0000250|UniProtKB:Q86TL2};
DE AltName: Full=STIM-activating enhancer encoded by TMEM110 {ECO:0000250|UniProtKB:Q86TL2};
DE AltName: Full=Transmembrane protein 110 {ECO:0000305};
GN Name=Stimate {ECO:0000250|UniProtKB:Q86TL2};
GN Synonyms=Tmem110 {ECO:0000312|RGD:735152};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Huang C.Q., Wu S.L., Liu S.;
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Acts as a regulator of store-operated Ca(2+) entry (SOCE) at
CC junctional sites that connect the endoplasmic reticulum (ER) and plasma
CC membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical
CC ER. SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+)
CC stores. Acts by interacting with STIM1, promoting STIM1 conformational
CC switch. Involved in STIM1 relocalization to ER-PM junctions.
CC Contributes to the maintenance and reorganization of store-dependent
CC ER-PM junctions. {ECO:0000250|UniProtKB:Q86TL2}.
CC -!- SUBUNIT: Homooligomer. Interacts with STIM1.
CC {ECO:0000250|UniProtKB:Q86TL2}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q86TL2}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q86TL2}. Note=Colocalizes with STIM1 at ER-
CC plasma membrane (ER-PM) junctions, also called cortical endoplasmic
CC reticulum (ER), in store-depleted calcium cells. May translocate to ER-
CC PM junctions in a STIM1-dependent manner in store-depleted cells.
CC {ECO:0000250|UniProtKB:Q86TL2}.
CC -!- DOMAIN: The GXXXG motif may mediate oligomerization. The C-terminus is
CC necessary for its localization at ER-plasma membrane (ER-PM) junctions
CC as well as for the store-dependent rearrangement of ER-PM junctions.
CC {ECO:0000250|UniProtKB:Q86TL2}.
CC -!- SIMILARITY: Belongs to the STIMATE family. {ECO:0000305}.
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DR EMBL; AY283801; AAP37472.1; -; mRNA.
DR EMBL; BC088092; AAH88092.1; -; mRNA.
DR RefSeq; NP_942069.1; NM_198774.2.
DR AlphaFoldDB; Q7TSW6; -.
DR STRING; 10116.ENSRNOP00000023314; -.
DR PaxDb; Q7TSW6; -.
DR Ensembl; ENSRNOT00000023314; ENSRNOP00000023314; ENSRNOG00000017051.
DR GeneID; 361110; -.
DR KEGG; rno:361110; -.
DR UCSC; RGD:735152; rat.
DR CTD; 375346; -.
DR RGD; 735152; Tmem110.
DR eggNOG; ENOG502S1HE; Eukaryota.
DR GeneTree; ENSGT00940000153920; -.
DR HOGENOM; CLU_040321_1_0_1; -.
DR InParanoid; Q7TSW6; -.
DR OMA; LQCGAWA; -.
DR OrthoDB; 897391at2759; -.
DR PhylomeDB; Q7TSW6; -.
DR TreeFam; TF324457; -.
DR PRO; PR:Q7TSW6; -.
DR Proteomes; UP000002494; Chromosome 16.
DR Bgee; ENSRNOG00000017051; Expressed in pancreas and 20 other tissues.
DR Genevisible; Q7TSW6; RN.
DR GO; GO:0032541; C:cortical endoplasmic reticulum; ISS:UniProtKB.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0140268; C:endoplasmic reticulum-plasma membrane contact site; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005246; F:calcium channel regulator activity; ISS:UniProtKB.
DR GO; GO:0032237; P:activation of store-operated calcium channel activity; ISS:UniProtKB.
DR GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; ISS:UniProtKB.
DR GO; GO:0070886; P:positive regulation of calcineurin-NFAT signaling cascade; ISS:UniProtKB.
DR InterPro; IPR022127; STIMATE/YPL162C.
DR PANTHER; PTHR31735; PTHR31735; 1.
DR Pfam; PF12400; STIMATE; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..288
FT /note="Store-operated calcium entry regulator STIMATE"
FT /id="PRO_0000243917"
FT TOPO_DOM 1..28
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q86TL2"
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 156..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..288
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:Q86TL2"
FT REGION 228..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..246
FT /note="Required for localization in the endoplasmic
FT reticulum"
FT /evidence="ECO:0000250|UniProtKB:Q86TL2"
FT MOTIF 149..153
FT /note="GXXXG motif"
FT /evidence="ECO:0000250|UniProtKB:Q86TL2"
FT COMPBIAS 228..256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 288 AA; 32470 MW; EEF0879C4D0D581F CRC64;
MQGPGGNVSR GLPGGPASTV ASGAGRCESG ALMHSFGIFL QGLLGVVAFS TLMLKRFREP
KHERRPWRIW FLDTSKQAIG MLFIHFANVY LADLTEEDPC SLYLINFLLD ATVGMLLIYV
GVRAVGVLVE WQQWESLRFG EYGDPLQCGA WVGQCALYIV IMIFEKSVVF IVLLILQWKK
VALLNPIENP DLKLAIVMLI VPFFVNAFMF WVVDNFLMRK GKTKAKLEER GANQDSRNGS
KVRYRRAASH EESESEILIS ADDEMEESDA EEDLRRPVKK KHRFGLPV
