ID   STIP1_DICDI             Reviewed;         564 AA.
AC   Q54DA8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Protein STIP1 homolog;
GN   Name=sti1; Synonyms=stip1; ORFNames=DDB_G0292404;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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DR   EMBL; AAFI02000190; EAL61181.1; -; Genomic_DNA.
DR   RefSeq; XP_629588.1; XM_629586.1.
DR   AlphaFoldDB; Q54DA8; -.
DR   SMR; Q54DA8; -.
DR   STRING; 44689.DDB0237783; -.
DR   PaxDb; Q54DA8; -.
DR   EnsemblProtists; EAL61181; EAL61181; DDB_G0292404.
DR   GeneID; 8628648; -.
DR   KEGG; ddi:DDB_G0292404; -.
DR   dictyBase; DDB_G0292404; sti1.
DR   eggNOG; KOG0548; Eukaryota.
DR   HOGENOM; CLU_000134_46_5_1; -.
DR   InParanoid; Q54DA8; -.
DR   OMA; HYSKAWE; -.
DR   PhylomeDB; Q54DA8; -.
DR   Reactome; R-DDI-3371497; HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand.
DR   PRO; PR:Q54DA8; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR   GO; GO:0030544; F:Hsp70 protein binding; ISS:dictyBase.
DR   GO; GO:0051879; F:Hsp90 protein binding; IBA:GO_Central.
DR   GO; GO:0006457; P:protein folding; ISS:dictyBase.
DR   Gene3D; 1.25.40.10; -; 3.
DR   InterPro; IPR041243; STI1.
DR   InterPro; IPR045248; Sti1-like.
DR   InterPro; IPR006636; STI1_HS-bd.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR001440; TPR_1.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR22904; PTHR22904; 1.
DR   Pfam; PF17830; STI1; 2.
DR   Pfam; PF00515; TPR_1; 2.
DR   Pfam; PF13181; TPR_8; 3.
DR   SMART; SM00727; STI1; 2.
DR   SMART; SM00028; TPR; 9.
DR   SUPFAM; SSF48452; SSF48452; 2.
DR   PROSITE; PS50005; TPR; 9.
DR   PROSITE; PS50293; TPR_REGION; 2.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..564
FT                   /note="Protein STIP1 homolog"
FT                   /id="PRO_0000328061"
FT   REPEAT          8..41
FT                   /note="TPR 1"
FT   REPEAT          43..75
FT                   /note="TPR 2"
FT   REPEAT          76..109
FT                   /note="TPR 3"
FT   DOMAIN          139..177
FT                   /note="STI1 1"
FT   REPEAT          244..277
FT                   /note="TPR 4"
FT   REPEAT          279..311
FT                   /note="TPR 5"
FT   REPEAT          319..352
FT                   /note="TPR 6"
FT   REPEAT          379..412
FT                   /note="TPR 7"
FT   REPEAT          414..446
FT                   /note="TPR 8"
FT   REPEAT          447..480
FT                   /note="TPR 9"
FT   DOMAIN          513..552
FT                   /note="STI1 2"
FT   REGION          197..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        203..236
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   564 AA;  63210 MW;  6983F8EC54659EAC CRC64;
     MSENAQKATE FKNQGNAAFS SKDYNSAVKC FDQAIELDPS NHILYSNRSA SLLALDKNED
     ALTDAKKAIE LKPDWSKGYL RETNALYKLG RFEEAEKSAE AGLKIDPTNQ QLEDALEDAQ
     YATTGAKDPA SAMANLFSAQ NLTKLRFNPK TAPFFQQPDF VAIMDQISKN PSLFSQYIAD
     QRFSTCLGVL LGVDINQGPG APPQSQQPTP QQPTPTPQQP TPTPQQPKPT EAPKKPEAPP
     MTESQKERDL GNKAYAKKEF EQAIVHYDKA VELDSSDILA MNNKAAVLIE QQKLDEAIET
     CKKALEKAQE IRADYRVKSK VYTRLGNIYL KKNQLDDAYK AYSSAVLEDK NADTTANMKK
     IEKLKKQRDD EAYLSVDQSI IEKNKGVEHF KKGEFPEAIK CFEEAIRRNP KDHTIYSNRS
     AAYSKLLEYK LAIKDADKCI ELEPTFIKGY IRKGTALFAM REYQQALEVY DQGLRIEANN
     PELLDLSRKT VAALTKLQST LTDEERLQQA AKDPEIQKIL SDPIMNQILK DMSENPAAAQ
     DHLKNPLIMA KFQKLVNAGI VKLG