STK19_DICDI
ID STK19_DICDI Reviewed; 391 AA.
AC Q54WC0;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Serine/threonine-protein kinase 19 homolog;
DE EC=2.7.11.1 {ECO:0000250|UniProtKB:P49842};
GN Name=STK19; Synonyms=G11; ORFNames=DDB_G0279761;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16596165; DOI=10.1371/journal.pgen.0020038;
RA Goldberg J.M., Manning G., Liu A., Fey P., Pilcher K.E., Xu Y., Smith J.L.;
RT "The dictyostelium kinome -- analysis of the protein kinases from a simple
RT model organism.";
RL PLoS Genet. 2:E38-E38(2006).
CC -!- FUNCTION: Serine/threonine-protein kinase.
CC {ECO:0000250|UniProtKB:P49842}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000250|UniProtKB:P49842};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:P49842};
CC -!- SIMILARITY: Belongs to the STK19 family. {ECO:0000305}.
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DR EMBL; AAFI02000032; EAL67560.1; -; Genomic_DNA.
DR RefSeq; XP_641538.1; XM_636446.1.
DR AlphaFoldDB; Q54WC0; -.
DR STRING; 44689.DDB0220709; -.
DR PaxDb; Q54WC0; -.
DR EnsemblProtists; EAL67560; EAL67560; DDB_G0279761.
DR GeneID; 8622211; -.
DR KEGG; ddi:DDB_G0279761; -.
DR dictyBase; DDB_G0279761; -.
DR eggNOG; ENOG502REI5; Eukaryota.
DR HOGENOM; CLU_706820_0_0_1; -.
DR InParanoid; Q54WC0; -.
DR OMA; FERYVIH; -.
DR PhylomeDB; Q54WC0; -.
DR PRO; PR:Q54WC0; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IBA:GO_Central.
DR GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
DR InterPro; IPR018865; Ser/Thr_kinase_19.
DR PANTHER; PTHR15243; PTHR15243; 1.
DR Pfam; PF10494; Stk19; 1.
PE 3: Inferred from homology;
KW ATP-binding; Kinase; Nucleotide-binding; Reference proteome;
KW Serine/threonine-protein kinase; Transferase.
FT CHAIN 1..391
FT /note="Serine/threonine-protein kinase 19 homolog"
FT /id="PRO_0000377459"
FT REGION 1..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 391 AA; 44813 MW; 71526147B77A5869 CRC64;
MNIKRNQNNS IDNNLSIDSN PSPIKKVKNH LDFSKSYNED DEPSNDLDLS FNTSNISNLS
NINGEEDNDD DDRENEPKDI DNPNPSITTT TATSTNSTLV KKTNNFLDFN FAFEPNKEED
DEEEDLNISL TTEDILLSQI ELLKAEWDYI TYNKSPPLVL QSVYHQSNKD SERSIQILKK
KGTIRLFQIA TSLNDYCIII TTDYIKNIEL LKIENTTIPN KIKPETLTNN MKNSSPIKSA
PIDTILLKRS EILDLFIKKL IPNFNEVSIT RSKLFQLLSI VNDDHHQQEN IITHLVQCGL
LLQKDDCTFT FSVPGAGGFF LNLMKGRKEI LSNIQRLKYK EILKKDLLKK KLKYSNVQMQ
LLIKDLLGLN KIKIIPTTQG ELIRCVQFDE L
