STK19_MOUSE
ID STK19_MOUSE Reviewed; 254 AA.
AC Q9JHN8; O70347;
DT 18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT 18-OCT-2001, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Serine/threonine-protein kinase 19;
DE EC=2.7.11.1 {ECO:0000250|UniProtKB:P49842};
DE AltName: Full=Protein RP1 {ECO:0000312|MGI:MGI:1860085};
GN Name=Stk19 {ECO:0000312|MGI:MGI:1860085};
GN Synonyms=Rp1 {ECO:0000312|MGI:MGI:1860085};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=129;
RX PubMed=14656967; DOI=10.1101/gr.1736803;
RA Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D.,
RA Hood L.;
RT "Analysis of the gene-dense major histocompatibility complex class III
RT region and its comparison to mouse.";
RL Genome Res. 13:2621-2636(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE OF 14-254.
RC STRAIN=BALB/cJ; TISSUE=Brain;
RA Yang Z., Shen L., Yu C.Y.;
RT "Conservation and polymorphism of the DOM3Z-RP1 gene pair located at the
RT RD-SKI2W-DOM3Z-RP1 complex of the MHC complement gene cluster.";
RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Serine/threonine-protein kinase that acts as a key regulator
CC of NRAS signaling by mediating phosphorylation of NRAS at 'Ser-89',
CC thereby enhancing NRAS-binding to its downstream effectors.
CC {ECO:0000250|UniProtKB:P49842}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000250|UniProtKB:P49842};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:P49842};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000250|UniProtKB:P49842};
CC Note=Divalent metal cations. Has a preference for Mn(2+).
CC {ECO:0000250|UniProtKB:P49842};
CC -!- SUBUNIT: Interacts (via N-terminus) with BAG1.
CC {ECO:0000250|UniProtKB:P49842}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P49842}.
CC -!- SIMILARITY: Belongs to the STK19 family. {ECO:0000305}.
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DR EMBL; AF049850; AAC05280.1; -; Genomic_DNA.
DR EMBL; BC022681; AAH22681.1; -; mRNA.
DR EMBL; AF099934; AAF26174.1; -; mRNA.
DR CCDS; CCDS28659.1; -.
DR RefSeq; NP_062315.1; NM_019442.3.
DR AlphaFoldDB; Q9JHN8; -.
DR STRING; 10090.ENSMUSP00000076686; -.
DR PhosphoSitePlus; Q9JHN8; -.
DR EPD; Q9JHN8; -.
DR MaxQB; Q9JHN8; -.
DR PaxDb; Q9JHN8; -.
DR PRIDE; Q9JHN8; -.
DR ProteomicsDB; 257451; -.
DR Antibodypedia; 28162; 195 antibodies from 24 providers.
DR DNASU; 54402; -.
DR Ensembl; ENSMUST00000077477; ENSMUSP00000076686; ENSMUSG00000061207.
DR GeneID; 54402; -.
DR KEGG; mmu:54402; -.
DR UCSC; uc008cdq.1; mouse.
DR CTD; 8859; -.
DR MGI; MGI:1860085; Stk19.
DR VEuPathDB; HostDB:ENSMUSG00000061207; -.
DR eggNOG; ENOG502RDW5; Eukaryota.
DR GeneTree; ENSGT00390000018295; -.
DR HOGENOM; CLU_064399_0_1_1; -.
DR InParanoid; Q9JHN8; -.
DR OMA; FERYVIH; -.
DR OrthoDB; 1329271at2759; -.
DR PhylomeDB; Q9JHN8; -.
DR TreeFam; TF105332; -.
DR BioGRID-ORCS; 54402; 3 hits in 79 CRISPR screens.
DR PRO; PR:Q9JHN8; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9JHN8; protein.
DR Bgee; ENSMUSG00000061207; Expressed in bone marrow and 78 other tissues.
DR ExpressionAtlas; Q9JHN8; baseline and differential.
DR Genevisible; Q9JHN8; MM.
DR GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.
DR GO; GO:0031267; F:small GTPase binding; ISO:MGI.
DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; ISS:UniProtKB.
DR GO; GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
DR InterPro; IPR018865; Ser/Thr_kinase_19.
DR PANTHER; PTHR15243; PTHR15243; 1.
DR Pfam; PF10494; Stk19; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Kinase; Manganese; Nucleotide-binding; Nucleus;
KW Reference proteome; Serine/threonine-protein kinase; Transferase.
FT CHAIN 1..254
FT /note="Serine/threonine-protein kinase 19"
FT /id="PRO_0000072276"
SQ SEQUENCE 254 AA; 28104 MW; 9F7BEAEC06DCC9D2 CRC64;
MNRKRRLLAS EAFGVKRRRA PGPVRADPLR TRAGSAREAI EELVKLFPRG LFEDALPPIA
LRSQVYSLVP DRTVADLQLK ELQELGEIRI IQLGFDLDAH GIVFTEDYRT RVLKACDGRP
CAGAVQKFLA SVLPACGDLS FQQDQMTQTY GFRDPEITQL VNAGVLTVRD AGSWWLAVPG
AGRFIKCFVK GRQAVLSMVR KAKYRELALS ELLGRRAPLA VRLGLAYHVH DLIGAQLVDC
VPTTSGTLLR LPDT
