ID   STK40_CHICK             Reviewed;         435 AA.
AC   Q7T0B1;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Serine/threonine-protein kinase 40;
DE            EC=2.7.11.1;
DE   AltName: Full=Serine/threonine-protein kinase lyk4;
GN   Name=STK40;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RA   Shan Y.X., Yu L.;
RT   "Cloning and characterization of human, mouse, rat, chick and frog lyk4
RT   gene.";
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be a negative regulator of NF-kappa-B and p53-mediated
CC       gene transcription. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC       protein kinase family. {ECO:0000305}.
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DR   EMBL; AY336056; AAQ01590.1; -; mRNA.
DR   RefSeq; NP_989797.1; NM_204466.1.
DR   AlphaFoldDB; Q7T0B1; -.
DR   SMR; Q7T0B1; -.
DR   STRING; 9031.ENSGALP00000040176; -.
DR   PaxDb; Q7T0B1; -.
DR   GeneID; 395120; -.
DR   KEGG; gga:395120; -.
DR   CTD; 83931; -.
DR   VEuPathDB; HostDB:geneid_395120; -.
DR   eggNOG; KOG0583; Eukaryota.
DR   InParanoid; Q7T0B1; -.
DR   OrthoDB; 1362510at2759; -.
DR   PhylomeDB; Q7T0B1; -.
DR   PRO; PR:Q7T0B1; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   CDD; cd13974; STKc_SHIK; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR024236; Ser/Thr_kinase_40.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR024104; Tribbles/Ser_Thr_kinase_40.
DR   PANTHER; PTHR22961; PTHR22961; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Nucleus;
KW   Reference proteome; Serine/threonine-protein kinase; Transferase.
FT   CHAIN           1..435
FT                   /note="Serine/threonine-protein kinase 40"
FT                   /id="PRO_0000252265"
FT   DOMAIN          35..332
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   ACT_SITE        197
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
FT                   ECO:0000255|PROSITE-ProRule:PRU10027"
FT   BINDING         41..49
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         66
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ   SEQUENCE   435 AA;  49497 MW;  1981AFFCB51E92F3 CRC64;
     MKRRASDRGA GETSTKAKAL CTGISGNNAK RAGPFILGPR LGNSPVPSIV QCLARKDGTD
     DFYQLKILTL EERGDKGIET QEERQGKMLL HTEYSLLSLL HNQEGVVHHH GLFQDRACEI
     IEDLEANRMV RKMKKRICLV LDCLCAHDFS DKTADLINLQ HYVIKEKRLS ERETVVIFYD
     VVRVVEALHK KNIVHRDLKL GNMVLNKRTH RITITNFCLG KHLVSEDDLL KDQRGSPAYI
     SPDVLSGRPY RGKPSDMWAL GVVLFTMLYG QFPFYDSIPQ ELFRKIKAAE YTIPEDGRVS
     ENTVCLIRKL LVLDPQQRLT ASEELDSLSS IIASWQSMSL LSGPLQVVPD IDDQVANPEH
     PQEAKVTEEC SQYEFENYMR QQLLLAEEKN TLHEAKSFLQ KRQFGNIPPV RRLGHDAQPM
     NPLDAAILAQ RYLRK