ID   STKL1_MACFA             Reviewed;         649 AA.
AC   Q4R793;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Serine/threonine kinase-like domain-containing protein STKLD1;
DE   AltName: Full=Serine/threonine kinase-like domain-containing protein 1;
DE   AltName: Full=Sugen kinase 071;
GN   Name=STKLD1; Synonyms=SGK071; ORFNames=QtsA-15869;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC       inactive.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC       kinase family. STKL subfamily. {ECO:0000255|PROSITE-ProRule:PRU00159}.
CC   -!- CAUTION: Asn-157 is present instead of the conserved Asp which is
CC       expected to be an active site residue. {ECO:0000305}.
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DR   EMBL; AB168928; BAE01029.1; -; mRNA.
DR   RefSeq; NP_001270899.1; NM_001283970.1.
DR   AlphaFoldDB; Q4R793; -.
DR   SMR; Q4R793; -.
DR   STRING; 9541.XP_005580562.1; -.
DR   GeneID; 101865077; -.
DR   CTD; 169436; -.
DR   eggNOG; KOG0665; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..649
FT                   /note="Serine/threonine kinase-like domain-containing
FT                   protein STKLD1"
FT                   /id="PRO_0000227569"
FT   DOMAIN          28..379
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          621..640
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         34..42
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         57
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ   SEQUENCE   649 AA;  72191 MW;  8EE40CCDE4FD3FFF CRC64;
     MLGPESDGRR PTQGERGPGY PGEPMDKYQV LYQLNPGALG VNLVVEEMET KVKRVIKQVE
     CMDDHQASQA LEELMPLLKL RHAHISVYRE LFIMWNGEIS SLYLCLVMEF NKLSFQEVIE
     DKRKAKEIID SKWMQNVLGQ VLDALEYLHH LDIIHRNLKP SNIILVSSDH CKLQDLSSNV
     LMTNKAKWNI RAESTEAMYL RKSLRQSPGS LETVLKTMEE KQIPDAETFG NLLPGMLQID
     PSDRTTIKDV VHITFLSGSF KSSCISLTLY RETVPASITD MLLEGNVASI LEVMQNFSGW
     PEVQFRAMKR LLKMPADQLG LPWRPELVEV VVTTMQLHDR VLDIQLCACS LLLHLLGQAM
     VHHPEAKALC NQAITSAVLS ALWSYPEEES LLVLVYSLLA ITTTQESQSE SESVSEELQN
     AGLLEHILEH LNSSLESRDV CVSGLGLLWA LLLDGIIVNK APLEKVPDLI SQVLATYPAD
     GEMAEASCGV FWLLSLLGCI KEQQFEQVVA LLLQSIRLCQ NRVLLVNNAY RGLASLVEVS
     ELAAFKVVVQ EEGGSGLSLI KETYQLHKDD PEVVENVGML LVHLASYEEI LPELVSSSMK
     ALVQEIKERF TSSLVSDRSA FSKPGLPPGG SPQPGCTASG GLEQMIAWN